Impacts of climate change on air-sea CO 2 exchange are strongly region dependent, particularly in the Southern Ocean. Yet, in the Southern Ocean the role of water masses in the uptake of anthropogenic carbon is still debated. Here, a methodology is applied that tracks the carbon flux of each Southern Ocean water mass in response to climate change. A global marine biogeochemical model was coupled to a climate model, making 140-yr Coupled Model Intercomparison Project phase 5 (CMIP5)-type simulations, where atmospheric CO 2 increased by 1% yr 21 to 4 times the preindustrial concentration (4 3 CO 2 ). Impacts of atmospheric CO 2 (carbon-induced sensitivity) and climate change (climate-induced sensitivity) on the water mass carbon fluxes have been isolated performing two sensitivity simulations. In the first simulation, the atmospheric CO 2 influences solely the marine carbon cycle, while in the second simulation, it influences both the marine carbon cycle and earth's climate. At 4 3 CO 2 , the cumulative carbon uptake by the Southern Ocean reaches 278 PgC, 53% of which is taken up by modal and intermediate water masses. The carbon-induced and climate-induced sensitivities vary significantly between the water masses. The carbon-induced sensitivities enhance the carbon uptake of the water masses, particularly for the denser classes. But, enhancement strongly depends on the water mass structure. The climate-induced sensitivities either strengthen or weaken the carbon uptake and are influenced by local processes through changes in CO 2 solubility and stratification, and by large-scale changes in outcrop surface (OS) areas. Changes in OS areas account for 45% of the climateinduced reduction in the Southern Ocean carbon uptake and are a key factor in understanding the future carbon uptake of the Southern Ocean.