Erratum for Research Article: “Single-cell RNA-seq and computational analysis using temporal mixture modeling resolves T
            <sub>H</sub>
            1/T
            <sub>FH</sub>
            fate bifurcation in malaria” by T. Lönnberg, V. Svensson, K. R. James, D. Fernandez-Ruiz, I. Sebina, R. Montandon, M. S. F. Soon, L. G. Fogg, A. S. Nair, U. N. Liligeto, M. J. T. Stubbington, L.-H. Ly, F. Otzen Bagger, M. Zwiessele, N. D. Lawrence, F. Souza-Fonseca-Guimaraes, P. T. Bunn, C. R. Engwerda, W. R.

Lönnberg, Tapio; Svensson,; James, R; Fernandez‐Ruiz, Daniel; Sebina, Ismail; Montandon, Ruddy; Soon, Msf; Fogg, LG; As, Nair; Liligeto, UN; Stubbington, Mjt; Ly, L-H; Bagger, Frederik Otzen; Zwiessele, Max; Lawrence, ND; Souza-Fonseca-Guimarães, Fernando; Bunn, PT; Engwerda, CR; Heath, WR; Billker, Oliver; Stegle, Oliver; Haque, Ashraful; Teichmann, Sarah A.

doi:10.1126/sciimmunol.aat1469

Sci. Immunol.

2018

DOI: 10.1126/sciimmunol.aat1469

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Erratum for Research Article: “Single-cell RNA-seq and computational analysis using temporal mixture modeling resolves T _H 1/T _FH fate bifurcation in malaria” by T. Lönnberg, V. Svensson, K. R. James, D. Fernandez-Ruiz, I. Sebina, R. Montandon, M. S. F. Soon, L. G. Fogg, A. S. Nair, U. N. Liligeto, M. J. T. Stubbington, L.-H. Ly, F. Otzen Bagger, M. Zwiessele, N. D. Lawrence, F. Souza-Fonseca-Guimaraes, P. T. Bunn, C. R. Engwerda, W. R.

Tapio Lönnberg¹,

Svensson Svensson²,

R James³

et al.

Abstract: Figure S26 has been updated.

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Hepatitis C virus micro-elimination: Where do we stand?

Mangia¹,

Cotugno²,

Cocomazzi³

et al. 2021

WJG

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Hepatitis C virus (HCV) elimination by 2030, using direct-acting antiviral treatments, has been promoted by the World Health Organization. This achievement is not attainable, however, particularly after the 2020 pandemic of the coronavirus disease 2019. Consequently, the more realistic objective of eliminating HCV from population segments for which targeted strategies of prevention and treatment are easily attained has been promoted in Europe, as a valid alternative. The underlying idea is that micro-elimination will ultimately lead to macro-elimination. The micro-elimination strategy may target different specific populations and at-risk groups. Different settings, including prisons and hospitals, have also been identified as micro-elimination scenarios. In addition, dedicated micro-elimination strategies have been designed that are tailored at the geographical level according to HCV epidemiology and individual country’s income. The main elements of a valid and successful micro-elimination project are reliable epidemiological data and active involvement of all the stakeholders. Community involvement represents another essential component for a successful program.

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Hepatitis C virus micro-elimination: Where do we stand?

Mangia¹,

Cotugno²,

Cocomazzi³

et al. 2021

WJG

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Malat1 Suppresses Immunity to Infection through Promoting Expression of Maf and IL-10 in Th Cells

Hewitson

West

James

et al. 2020

The Journal of Immunology

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Despite extensive mapping of long noncoding RNAs in immune cells, their function in vivo remains poorly understood. In this study, we identify over 100 long noncoding RNAs that are differentially expressed within 24 h of Th1 cell activation. Among those, we show that suppression of Malat1 is a hallmark of CD4 + T cell activation, but its complete deletion results in more potent immune responses to infection. This is because Malat1 2/2 Th1 and Th2 cells express lower levels of the immunosuppressive cytokine IL-10. In vivo, the reduced CD4 + T cell IL-10 expression in Malat1 2/2 mice underpins enhanced immunity and pathogen clearance in experimental visceral leishmaniasis (Leishmania donovani) but more severe disease in a model of malaria (Plasmodium chabaudi chabaudi AS). Mechanistically, Malat1 regulates IL-10 through enhancing expression of Maf, a key transcriptional regulator of IL-10. Maf expression correlates with Malat1 in single Ag-specific Th cells from P. chabaudi chabaudi AS-infected mice and is downregulated in Malat1 2/2 Th1 and Th2 cells. The Malat1 RNA is responsible for these effects, as antisense oligonucleotide-mediated inhibition of Malat1 also suppresses Maf and IL-10 levels. Our results reveal that through promoting expression of the Maf/IL-10 axis in effector Th cells, Malat1 is a nonredundant regulator of mammalian immunity.

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Abstract: Figure S26 has been updated.

Cited by 2 publications

References 0 publications

Hepatitis C virus micro-elimination: Where do we stand?

Hepatitis C virus micro-elimination: Where do we stand?

Malat1 Suppresses Immunity to Infection through Promoting Expression of Maf and IL-10 in Th Cells

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