Erratum. Factors Associated With Diabetes-Specific Health-Related Quality of Life in Youth With Type 1 Diabetes: The Global TEENs Study. Diabetes Care 2017;40:1002—1009

Anderson, Barbara J.; Laffel, Lori M.; Domenger, Catherine; Danne, Thomas; Phillip, Moshe; Mazza, Carmen; Hanås, Ragnar; Waldron, Sheridan; Beck, Roy W.; Calvi-Gries, Francoise; Mathieu, Chantal

doi:10.2337/dc18-er03

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“…It is recognized that the exclusion of other covariates (e.g., type of insulin administration and diabetes duration) may have affected the results. 10,21,[26][27][28][29] Fourth, based on new insights on QoL, it can be argued that the PedsQL-DM might not be the most optimal assessment of diabetes-specific QoL. 30 Since 'hypoglycaemia-specific' QoL measures are not currently available, the full understanding of the impact of hypoglycaemia on QoL remains elusive.…”

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confidence: 99%

Hypoglycaemia and diabetes‐specific quality of life in adolescents with type 1 diabetes

et al. 2021

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To examine whether frequency, perceived severity and fear of hypoglycaemia are independently associated with diabetes-specific quality of life in adolescents with type 1 diabetes. Methods: Cross-sectional self-reported data on demographics, frequency and perceived severity of both self-treated and severe hypoglycaemia, fear of hypoglycaemia (Hypoglycaemia Fear Survey-Child version) and diabetes-specific quality of life (Pediatric Quality of Life Diabetes Module; PedsQL-DM) were obtained from the project 'Whose diabetes is it anyway?'. Hierarchical regression analyses were performed for the total scale and recommended summary scores of the PedsQL-DM as dependent variables; independent variables were entered in the following steps: (1) age, gender and HbA 1c , (2) frequency of hypoglycaemia, (3) perceived severity of hypoglycaemia and (4) fear of hypoglycaemia. Results: Adolescents (12-18 years; n = 96) completed questionnaires. In the first three steps, female gender (p < 0.05), higher HbA 1c (p < 0.05), higher frequency of severe hypoglycaemia (p < 0.05) and higher perceived severity of severe (p < 0.05) and self-treated hypoglycaemia (p < 0.001) were significantly associated with lower diabetes-specific quality of life (β ranging from 0.20 to 0.35). However, in the final model only fear of hypoglycaemia was significantly associated with QoL (p < 0.001).Adolescents with greater fear reported lower diabetes-specific quality of life, with 52% explained variance. This pattern was observed across subdomains of diabetesspecific quality of life. Conclusions: Fear of hypoglycaemia was the only factor independently associated with diabetes-specific quality of life, whereas frequency and perceived severity of hypoglycaemia were not. These findings highlight the importance of awareness and assessment of fear of hypoglycaemia in clinical practice.

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