Erratum: Corrigendum: Quantitative flux analysis reveals folate-dependent NADPH production

Fan, Jing; Ye, Jiangbin; Kamphorst, Jurre J.; Shlomi, Tomer; Thompson, Craig B.; Rabinowitz, Joshua D.

doi:10.1038/nature13675

Cited by 8 publications

(2 citation statements)

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“…Mitochondrial redox homeostasis is regulated by NADPH. [ 104,105 ] In proliferating cells, the largest contributor of NADPH is the oxidized pentose phosphate pathway. Surprisingly, the almost comparable contribution comes from serine‐driven one‐carbon metabolism, where the oxidation of methylenetetrahydrofolate to 10‐methyl‐tetrahydrofolate is coupled with the reduction of NADP to NADPH.…”

Section: Functions Of One Carbon Metabolism In Mammals During Pregnancymentioning

confidence: 99%

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One Carbon Metabolism and Mammalian Pregnancy Outcomes

Cai

Shuang

Gao

et al. 2020

Molecular Nutrition Food Res

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One‐carbon metabolism is involved in varieties of physiological processes in mammals, including nucleic acid synthesis, amino acid homeostasis, epigenetic regulation, redox balance and neurodevelopment. The current evidence linking levels of one‐carbon nutrients during pregnancy to the development of oocytes, embryos, and placentas, as well as maternal and offspring health, is reviewed. The sources of mammalian one‐carbon units, the pathways active in mammalian one‐carbon metabolism, the maternal and fetal needs for one‐carbon units and their functions during pregnancy are described. The demand for one‐carbon metabolism is highest during pregnancy compared to the entire lifetime of a mammal. The primary types of one‐carbon metabolism in mammals are the folate cycle, methionine cycle and transsulfuration pathway, which varies at different pregnancy stages (e.g., methylation programming of embryo, neural development of fetus, fetal growth and placenta development). Therefore, an overall consideration of one‐carbon metabolism requirements for different pregnancy stages, is called for, specifically, the balance of all nutrients involved, not just one single nutrient in one‐carbon metabolism. Moreover, the establishment of an ideal one‐carbon metabolism requirement model is suggested according to the requirements for different pregnancy stages to support optimal pregnancy outcomes and maternal and offspring health.

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Section: Functions Of One Carbon Metabolism In Mammals During Pregnancymentioning

confidence: 99%

“…Surprisingly, the almost comparable contribution comes from serine‐driven one‐carbon metabolism, where the oxidation of methylenetetrahydrofolate to 10‐methyl‐tetrahydrofolate is coupled with the reduction of NADP to NADPH. [ 105 ]…”

Section: Functions Of One Carbon Metabolism In Mammals During Pregnancymentioning

confidence: 99%

One Carbon Metabolism and Mammalian Pregnancy Outcomes

Cai

Shuang

Gao

et al. 2020

Molecular Nutrition Food Res

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Formate metabolism in health and disease

Pietzke

Meiser

Vazquez

2020

Molecular Metabolism

136

117

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Limits of aerobic metabolism in cancer cells

Fernández-de-Cossio-Díaz

Vazquez

2017

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Cancer cells exhibit high rates of glycolysis and glutaminolysis. Glycolysis can provide energy and glutaminolysis can provide carbon for anaplerosis and reductive carboxylation to citrate. However, all these metabolic requirements could be in principle satisfied from glucose. Here we investigate why cancer cells do not satisfy their metabolic demands using aerobic biosynthesis from glucose. Based on the typical composition of a mammalian cell we quantify the energy demand and the OxPhos burden of cell biosynthesis from glucose. Our calculation demonstrates that aerobic growth from glucose is feasible up to a minimum doubling time that is proportional to the OxPhos burden and inversely proportional to the mitochondria OxPhos capacity. To grow faster cancer cells must activate aerobic glycolysis for energy generation and uncouple NADH generation from biosynthesis. To uncouple biosynthesis from NADH generation cancer cells can synthesize lipids from carbon sources that do not produce NADH in their catabolism, including acetate and the amino acids glutamate, glutamine, phenylalanine and tyrosine. Finally, we show that cancer cell lines have an OxPhos capacity that is insufficient to support aerobic biosynthesis from glucose. We conclude that selection for high rate of biosynthesis implies a selection for aerobic glycolysis and uncoupling biosynthesis from NADH generation.

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Erratum: Corrigendum: Quantitative flux analysis reveals folate-dependent NADPH production

Abstract: In the interests of transparency, we wish to amend the 'Competing financial interests' section of our Letter to read: ''J.D.R. is the only author with a competing financial interest with respect to the current manuscript. He is involved in the founding of Raze Therapeutics.''

Cited by 8 publications

References 1 publication

One Carbon Metabolism and Mammalian Pregnancy Outcomes

One Carbon Metabolism and Mammalian Pregnancy Outcomes

Formate metabolism in health and disease

Limits of aerobic metabolism in cancer cells

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