Erratum: Corrigendum: PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells

Gur-Cohen, Shiri; Itkin, Tomer; Chakrabarty, Sagarika; Graf, Claudine; Ludin, Aya; Golan, Karin; Kalinkovich, Alexander; Ledergor, Guy; Wong, Eitan; Niemeyer, Elisabeth; Porat, Ziv; Erez, Ayelet; Sagi, Irit; Esmon, Charles T.; Ruf, Wolfram; Lapidot, Tsvee

doi:10.1038/nm0416-446b

Cited by 2 publications

(1 citation statement)

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“…Various positive regulators of the blood coagulation pathways, including platelets, the TF pathway, and proteolytic signaling involving protease-activated receptors (PARs), are important regulators of both innate and adaptive immune responses. 48,49 More importantly, recent evidence suggests that extravascular coagulation may contribute to tumor immune evasion and promote resistance to ICI treatment. [21][22][23][24] In this regard, pre-clinical data suggest that thrombin promotes tumor immune evasion via proteolysis of platelet-bound glycoprotein A repetitions predominant (GARP) to activate receptor for latent transforming growth factor-β1 (LTGF-β1).…”

Section: Discussionmentioning

confidence: 99%

Associations Between Immune-Related Venous Thromboembolism and Efficacy of Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis

Li,

Tang

et al. 2023

Clin Appl Thromb Hemost

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This study aims to summarize the available data and determine if the presence of venous thromboembolism (VTE) immune-related adverse event (irAE) in patients with immune checkpoint inhibitor (ICI) therapy is associated with improved treatment efficacy and clinical outcomes, which in turn was used to help optimize patient selection for anticoagulation therapy and inform rational treatment strategies for overcoming the mechanisms of ICI resistance. PubMed, Embase, Web of Science, and Cochrane Library were searched up to March 18, 2023, for studies assessing the relationship between VTE irAE development during ICI therapy and cancer outcomes. Seven primary articles with a total of 4437 patients were included in the overall survival (OS) meta-analysis. Patients with VTE had a significant increase in overall mortality compared to patients without VTE in adjusted hazard ratios (HRs 1.36, 95% confidence interval [CI] 1.06-1.75, P = .02). In the studies where immortal time bias (ITB) was accounted for, patients with VTE irAE also had poor OS than those without. HR and the corresponding 95% CI values in the non-ITB group were 2.53 (1.75-3.66, P < .00001) with low heterogeneity ( P = .17, I2 = 48%) and 1.21 (1.06-1.37, P = .004) in the ITB group with no heterogeneity ( P = .95, I2 = 0%), respectively. Despite the heterogeneity identified, the evidence does suggest that VTE irAE occurrence could be served as a prognostic indicator, with higher frequencies of occurrence associated with poorer OS. However, the fundamental role of this association with clinical consequences should be further investigated in large cohorts and clinical trials.

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Section: Discussionmentioning

confidence: 99%

Associations Between Immune-Related Venous Thromboembolism and Efficacy of Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis

Li,

Tang

et al. 2023

Clin Appl Thromb Hemost

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Flow cytometry what you see matters: Enhanced clinical detection using image-based flow cytometry

McFarlin

Gary

2017

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Erratum: Corrigendum: PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells

Abstract: In the version of this article initially published, the article number in reference 13 is incorrectly stated as '100ra190' and should be '100ra90'. The error has been corrected in the HTML and PDF versions of the article.

Cited by 2 publications

References 1 publication

Associations Between Immune-Related Venous Thromboembolism and Efficacy of Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis

Associations Between Immune-Related Venous Thromboembolism and Efficacy of Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis

Flow cytometry what you see matters: Enhanced clinical detection using image-based flow cytometry

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