Erratum: correction: The DNA sequence of human chromosome 22

Dunham, Ian; Shimizu, N; Roe, Bruce A.; Chissoe, Stephanie L.

doi:10.1038/35009158

Cited by 17 publications

(16 citation statements)

References 12 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Unlike other STIR sequences found in the human genome [5,12,13], this is the first example of a STIR whose exact chromosomal position is known at the nucleotide level. In the reported chromosome 22 sequence, the 93 bp unit is repeated 14 times with 92–98% sequence similarity ([14]; http://NT001128, GenBank). A similar inter‐chromosomal distribution has been reported by Brown et al, using the TelBam11 fragment isolated from a YAC clone [6].…”

Section: Discussionmentioning

confidence: 99%

Newly identified repeat sequences, derived from human chromosome 21qter, are also localized in the subtelomeric region of particular chromosomes and 2q13, and are conserved in the chimpanzee genome

et al. 2000

View full text Add to dashboard Cite

Subtelomeric regions have been a target of structural and functional studies of human chromosomes. Markers having a defined structure are especially useful to such studies. Here, we report 93 bp tandem repeat sequences found in the subtelomeric region of human chromosome 21q. They were also detected in the telomeric region of several other chromosomes. Interestingly, the repeat was also found in the 2q13 region which is known to be a position of chromosomal fusion, a major difference between the human and chimpanzee karyotypes. To the best of our knowledge, this repetitive sequence is a new member of human subtelomeric interspersed repeats. ß

show abstract

Section: Discussionmentioning

confidence: 99%

Newly identified repeat sequences, derived from human chromosome 21qter, are also localized in the subtelomeric region of particular chromosomes and 2q13, and are conserved in the chimpanzee genome

et al. 2000

View full text Add to dashboard Cite

show abstract

“…These predicted genes as well as putative genes provide targets for experimental validation (8). Immunoglobulin segments and pseudogenes found on chromosomes 22 (1) and 14 (7) have also been given unique tags. These classifications have been extended across all the species in Vega with the only exception being that the specific model organism databases, e.g.…”

Section: Gene Classification and Standardization Of Annotationmentioning

confidence: 99%

“…In 1999 the DNA sequence of chromosome 22, the first human chromosome to be fully sequenced, was published (1). It provided a snapshot of the complexity of genes within a chromosomal landscape and set the standard for manual annotation, which the rest of the community was to follow.…”

Section: Introductionmentioning

confidence: 99%

The Vertebrate Genome Annotation (Vega) database

Ashurst

2004

Nucleic Acids Research

131

113

View full text Add to dashboard Cite

The Vertebrate Genome Annotation (Vega) database (http://vega.sanger.ac.uk) has been designed to be a community resource for browsing manual annotation of finished sequences from a variety of vertebrate genomes. Its core database is based on an Ensembl-style schema, extended to incorporate curation-specific metadata. In collaboration with the genome sequencing centres, Vega attempts to present consistent high-quality annotation of the published human chromosome sequences. In addition, it is also possible to view various finished regions from other vertebrates, including mouse and zebrafish. Vega displays only manually annotated gene structures built using transcriptional evidence, which can be examined in the browser. Attempts have been made to standardize the annotation procedure across each vertebrate genome, which should aid comparative analysis of orthologues across the different finished regions.

show abstract

“…Random sequencing [1], sequence skimming of randomly selected cosmids [5] and sequencing of select loci [25–28] all have confirmed a high gene density in the Fugu. Whereas the human genome is just 3% coding sequence [29], Fugu contains 17% [5] coding sequence. This predicts 68 000 genes of 1 kb coding length in the Fugu, at a density of one gene per 6 kb which is close to that found in the invertebrates, the nematode (5 kb per gene) [30] and fruit fly (8.5 kb per gene) [31].…”

Section: Gene Density and Syntenymentioning

confidence: 99%

Fugu: a compact vertebrate reference genome

2000

View full text Add to dashboard Cite

At 400 Mb, the Japanese pufferfish, Fugu rubripes, has the smallest vertebrate genome but has a similar gene repertoire to other vertebrates. Its genes are densely packed with short intergenic and intronic sequences devoid of repetitive elements. It likely has a mutational bias towards DNA elimination and is probably close to a`minimal' vertebrate genome. As such it is a useful reference genome for gene discovery and gene validation in other vertebrates. Its usefulness in the discovery of conserved regulatory elements has already been demonstrated. The Fugu genome sequence is a good complement to genetic studies in other vertebrates. ß

show abstract

Erratum: correction: The DNA sequence of human chromosome 22

Cited by 17 publications

References 12 publications

Newly identified repeat sequences, derived from human chromosome 21qter, are also localized in the subtelomeric region of particular chromosomes and 2q13, and are conserved in the chimpanzee genome

Newly identified repeat sequences, derived from human chromosome 21qter, are also localized in the subtelomeric region of particular chromosomes and 2q13, and are conserved in the chimpanzee genome

The Vertebrate Genome Annotation (Vega) database

Fugu: a compact vertebrate reference genome

Contact Info

Product

Resources

About