Erratum: Correction of Figure: Simvastatin Reduces Capsular Fibrosis around Silicone Implants

Chung, Kyu Jin; Park, Ki Rin; Lee, Jun Ho; Kim, Tae-Gon; Kim, Yong Ha

doi:10.3346/jkms.2016.31.11.1854

Cited by 1 publication

(1 citation statement)

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“…Several in vitro and in vivo studies have investigated a possible prophylactic influence of different drugs or modifications of the implants providing no distinct evidence of effectiveness in the past [6]. This includes the administration of Simvastatin, Collagenase or Triamcinolone into capsular tissue and the coating of implants with antibiotics, spider silk, Montelukast or Triamcinolone [7][8][9][10][11][12][13][14][15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Size matters—in vitro behaviour of human fibroblasts on textured silicone surfaces with different pore sizes

Tolksdorf

Horch

Grüner

et al. 2020

J Mater Sci: Mater Med

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Capsular contracture remains a challenge in plastic surgery and represents one of the most common postoperative complications following alloplastic breast reconstruction. The impact of the surface structure of silicone implants on the foreign body reaction and the behaviour of connective tissue-producing cells has already been discussed. The aim of this study was to investigate different pore sizes of silicone surfaces and their influence on human fibroblasts in an in vitro model. Four different textures (no, fine, medium and coarse texture) produced with the salt-loss technique, have been assessed in an in vitro model. Human fibroblasts were seeded onto silicone sheets and evaluated after 1, 4 and 7 days microscopically, with viability assay and gene expression analysis. Comparing the growth behaviour and adhesion of the fibroblasts on the four different textures, a dense cell layer, good adhesion and bridge-building ability of the cells could be observed for the fine and medium texture. Cell number and viability of the cells were increasing during the time course of experiments on every texture. TGFß1 was lowest expressed on the fine and medium texture indicating a trend for decreased fibrotic activity. For silicone surfaces produced with the salt-loss technique, we were able to show an antifibrotic effect of smaller sized pores. These findings underline the hypothesis of a key role of the implant surface and the pore size and pore structure in preventing capsular contracture.

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