Erratum: Can landscape ecology untangle the complexity of antibiotic resistance?

Singer, Randall S.; Ward, Micheal P.; Maldonado, George

doi:10.1038/nrmicro1593

Cited by 10 publications

(5 citation statements)

References 87 publications

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“…Conversely, it has been reported that wild population that has never been exposed to humans is free of resistance to antibiotics [13]. To provide a broader picture of AMR in wildlife, prevalence studies across different habitats, combined with other spatial data (e.g., the presence of fosterage and human influence), should be encouraged [8,14,15].…”

Section: Introductionmentioning

confidence: 99%

Wild Micromammals as Bioindicators of Antibiotic Resistance in Ecopathology in Northern Italy

Zanardi

Iemmi

Spadini

et al. 2020

Animals

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Antimicrobial resistance (AMR) is an increasing threat to human health and an important issue also in the natural environment. For this study, an ecopathological approach was applied to the monitoring of the antimicrobial resistance in the province of Parma, Northern Italy. Fourteen monitoring sites and seventy-four faecal samples from four species of wild micromammals (Apodemus sylvaticus, Microtus savii, Mus domesticus and Suncus etruscus) were collected. Samples were subjected to bacteriological examination and antimicrobial susceptibility testing. Antibiotics belonging to 13 different antibiotic classes were tested. Collected data showed a prevalence of multi-drug resistant (MDR) strains of 55.13% and significant differences in the prevalence of MDR strains among the different micromammal species, while sex, age and anthropization level did not significantly affected MDR strains prevalence. Moreover, a high prevalence of bacterial strains resistant to colistin (95%), gentamicin (87%) and amikacin (83%) was observed. To our knowledge, this is the first report on antibiotic resistance in wild micromammals in the province of Parma.

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Section: Introductionmentioning

confidence: 99%

Wild Micromammals as Bioindicators of Antibiotic Resistance in Ecopathology in Northern Italy

Zanardi

Iemmi

Spadini

et al. 2020

Animals

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“…Densely populated urban areas are historically seen as hotspots for antibiotic resistant bacteria [91,92] but microorganisms with these characteristics associated with humans have been described in non-clinical environments, such as in remote areas of the planet, far from direct anthropogenic pressure, apparently free from exposure to antibiotics, as in regions of the Amazon, Bolivia and Antarctica. It is suspected that this resistance may have been caused by the existence in these regions of military bases, domestic animals, water, fishing boats, scientific expeditions and/or on-board tourism [93,94,95,96,97].…”

Section: Discussionmentioning

confidence: 99%

Wild birds as reservoirs of multidrug-resistant enterobacteria in Mulungu, Brazil

Beleza

Maciel

Carreira

et al. 2021

Preprint

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Caatinga is a biome unique to Brazil that is degraded by anthropogenic actions, which lead to the loss of biodiversity putting many species at risk of extinction. The Ceará State is located in the Caatinga and has a rich avifauna comprised of 433 species including 13 species that are threatened with extinction, which are found in the Baturité Massif. The aim of this study was to investigate the frequency and diversity of enterobacteria in wild birds and to determine their susceptibility to antimicrobials. Cloacal swab samples were collected from 50 individuals of 28 different species, including the Ceara Gnatheter (Conopophaga cearae) and Red-necked Tanager (Tangara cyanocephala cearensis), which are classified as vulnerable (VU) by the Brazilian Ministry of the Environment. A total of 55 isolates belonging to 14 different species of Enterobacteriaceae were identified. Among these, Pantoea agglomerans and Escherichia coli were the most prevalent species with isolation rates of 36% and 26%, respectively. The highest rate of antimicrobial resistance found was to ampicillin (41.8%), followed by nalidixic Acid (36.3%) and amoxicillin associated with clavulanic acid (32.7%). The drugs with the best efficacy were tobramycin (96.4%), ciprofloxacin (92.6%) and tetracycline (90.9%). Multidrug resistance was observed in 23.5% of the analyzed strains. This research provides important information about the composition of the cloacal microbiota of wild birds in Mulungu, Brazil, as well as their health status. In addition, these results demonstrate that they harbor multidrug-resistant strains of Enterobacteriaceae.

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“…A principal component analysis (PCA) was conducted to assess how the ARGs clustered among samples, which could indicate genes under coselection (Singer et al, 2006). The absolute number of gene copies per gram of sediment was used for the genes included in the analysis.…”

Section: Discussionmentioning

confidence: 99%

“…There is evidence that ARGs can be found in the environment, but quantifying the attribution to specific point sources, such as fish farms, is lacking (Williams-Nguyen et al, 2016). Given the findings of our previous systematic review (Bueno et al, 2017), which highlighted major limitations in the study design of many environmental AMR studies, this investigation focused on the design of the study and appropriate data analysis methods to inform attribution conclusions (Singer et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Antibiotic Resistance Genes in Freshwater Trout Farms in a Watershed in Chile

et al. 2019

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Point sources such as wastewater treatment plants, terrestrial agriculture, and aquaculture may release antibiotic residues, antibiotic resistant bacteria, and antibiotic resistance genes (ARGs) into aquatic ecosystems. However, there is a lack of quantitative studies attributing environmental ARG abundance to specific sources. The goal of this study was to evaluate the role of freshwater trout farms in the release and dissemination of ARGs into the environment. Sediment samples upstream and downstream from five rainbow trout farms were collected over time in southern Chile. A microfluidic quantitative polymerase chain reaction approach was used to quantify an ARG array covering different mechanisms of resistance, and data were analyzed using principal component analysis (PCA) and linear mixed regression models. Surveys were also conducted to obtain information about management practices, including antibiotic use, at the farms. Florfenicol and oxytetracycline were used at these farms, although at different rates. A total of 93 samples were analyzed. In the PCA, strB, sul1, sul2, qacG, tet(A), tet(B), tet(C), tet(W), and floR grouped together. A statistically significant increase in abundance of qacG, strB, sul1, and several tet genes was found downstream from the farms compared with upstream sites, and retention ponds had the highest ARG abundance at each site. Antibiotic resistance gene levels returned to baseline at an average distance of 132.7 m downstream from the farms. Although results from this study indicate an influence of trout farms on the presence of ARGs in the immediate environment, the extent of their contribution to ARG dissemination is unknown and deserves further investigation. Core Ideas Point sources contribute to antimicrobial resistance (AMR) in the environment. Antibiotic resistance genes (ARG) were quantified in river sediment samples. Freshwater trout farms in southern Chile increased ARG abundance in the watershed. The extent of the contribution of the trout farms on ARG dissemination is uncertain. Epidemiological methods are needed to attribute environmental AMR to specific point sources.

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Erratum: Can landscape ecology untangle the complexity of antibiotic resistance?

Cited by 10 publications

References 87 publications

Wild Micromammals as Bioindicators of Antibiotic Resistance in Ecopathology in Northern Italy

Wild Micromammals as Bioindicators of Antibiotic Resistance in Ecopathology in Northern Italy

Wild birds as reservoirs of multidrug-resistant enterobacteria in Mulungu, Brazil

Antibiotic Resistance Genes in Freshwater Trout Farms in a Watershed in Chile

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