“…BI1 has been reported to attenuate mitochondrial apoptosis via repressing Bax-mediated mitochondrial outer membrane hyperpermeability (Ruberti, Lai, & Brandizzi, 2018). Besides, several mitochondrial physiological processes are affected by BI1 including calcium homeostasis (Carrara, Parsons, Saraiva, & Smith, 2017), autophagy (Castillo et al, 2017), ROS production (Zhou, Shi, Hu, Zhu, et al, 2018), and cytosolic acidification (G. H. Lee et al, 2016). Notably, increased BI1 protects the liver and kidney IR injury via regulating cell apoptosis.…”