Erratum: Axo-myelinic neurotransmission: a novel mode of cell signalling in the central nervous system

Micu, Ileana; Plemel, Jason R.; Caprariello, Andrew V.; Nave, Klaus‐Armin; Stys, Peter K.

doi:10.1038/nrn.2017.166

Cited by 18 publications

(19 citation statements)

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“…Since in these mice, Ras activity is only enhanced in neurons, an indirect impact of the neuronal compartment on oligodendrocyte responses to hyperoxia can be assumed. These results clearly support the current concept of an intense communication between neurons/axons and oligodendrocytes/myelin ( 31 , 33 ). Interestingly, elevated Ras signaling exclusively in oligodendrocytes has been shown to mediate opposite effects ( 45 ).…”

Section: Discussionsupporting

confidence: 90%

“…Myelination is the key for efficient nerve conduction velocity proposed to strengthen circuitry throughout the nervous system ( 40 ). However, recent evidence also suggests a substantial impact of neuronal activity on myelination ( 31 , 33 ). Our results demonstrate that the selective neuronal activation of the small GTPase Ras protects against hyperoxia-mediated neuronal but also oligodendrocyte degeneration and hypomyelination.…”

Section: Discussionmentioning

confidence: 99%

“…Second, increased neuronal activity described for syn Ras mice displayed by enhanced glutamatergic transmission, and long-term potentiation ( 30 ) may explain our findings. Whereas the essential need of intact myelination for preservation and maintenance of axonal structure and function is without any doubt ( 47 ), there is compelling evidence for a substantial communication into the other direction, i.e., an activity-dependent signaling from neurons/axons to oligodendrocytes/myelin ( 33 ). Accordingly, recent studies indicate that axonal action potentials activate myelinic NMDA receptors ( 48 ) resulting in impaired metabolic coupling between axons and oligodendrocytes ( 49 ).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, neuronal Ras activation in adult mice leads to an increase of dendritic spine density and synapses as well as increased neuronal activity ( 30 ). Taking into account that oligodendrocyte development is not only controlled intrinsically, e.g., by transcription factors but also by neuronal activity ( 31 – 33 ), modulation of neuronal activity and signaling pathways may determine oligodendrocyte responses and subsequent effects on myelination in oxygen-related injury of the immature brain.…”

Section: Introductionmentioning

confidence: 99%

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Protection of Oligodendrocytes Through Neuronal Overexpression of the Small GTPase Ras in Hyperoxia-Induced Neonatal Brain Injury

et al. 2018

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Prematurely born infants are highly susceptible to various environmental factors, such as inflammation, drug exposure, and also high environmental oxygen concentrations. Hyperoxia induces perinatal brain injury affecting white and gray matter development. It is well known that mitogen-activated protein kinase signaling is involved in cell survival, proliferation, and differentiation. Therefore, we aim to elucidate cell-specific responses of neuronal overexpression of the small GTPase Ras on hyperoxia-mediated brain injury. Six-day-old (P6) synRas mice (neuronal Ras overexpression under the synapsin promoter) or wild-type littermates were kept under hyperoxia (80% oxygen) or room air (21% oxygen) for 24 h. Apoptosis was analyzed by Western blot of cleaved Caspase-3 and neuronal and oligodendrocyte degeneration via immunohistochemistry. Short-term differentiation capacity of oligodendrocytes was assessed by quantification of myelin basic protein expression at P11. Long-lasting changes of hyperoxia-induced alteration of myelin structures were evaluated via transmission electron microscopy in young adult animals (P42). Western blot analysis of active Caspase-3 demonstrates a significant upregulation in wild-type littermates exposed to hyperoxia whereas synRas mice did not show any marked alteration of cleaved Caspase-3 protein levels. Immunohistochemistry revealed a protective effect of neuronal Ras overexpression on neuron and oligodendrocyte survival. Hyperoxia-induced hypomyelination in wild-type littermates was restored in synRas mice. These short-term protective effects through promotion of neuronal survival translated into long-lasting improvement of ultrastructural alterations of myelin sheaths in mice with neuronal overexpression of Ras compared with hyperoxic wild-type mice. Our data suggest that transgenic increase of neuronal Ras activity in the immature brain results in secondary protection of oligodendrocytes from hyperoxia-induced white matter brain injury.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Protection of Oligodendrocytes Through Neuronal Overexpression of the Small GTPase Ras in Hyperoxia-Induced Neonatal Brain Injury

et al. 2018

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“…Glutamate is required for normal brain function; the presence of excessive amounts of glutamate can lead to excitotoxic cell death 5 .…”

mentioning

confidence: 99%

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2018

IJPSR

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This study evaluated the anticonvulsant effect of different extracts of Centella asiatica (CA) with particular reference to lipid metabolism in different regions of rat brain. The rats were randomly divided into 4 groups having 6 in each group: i.e. Control group received saline, PTZ-induced epileptic group (60mg/kg b.w op/ 1 day), epileptic group pretreated with chloroform extract (CE), epileptic group pretreated with aqueous (AE) extract and epileptic group pretreated with diazepam (DP; Reference control) (2 mg/kg b.w/ip/ day). The CA extract is administered at the dose of 200 mg/kg body weight orally for one week. The experimental results were observed that the decreased content of phospholipids in the entire brain regions i.e. Cerebral cortex (CC), Cerebellum (CB), Hippocampus (HC) and Pons medulla (PM); total cholesterol, triglycerides and increased content of Lipid peroxidation in epileptic rats. The reversal changes were observed on pretreatment with the chloroform extract of CA and diazepam. Hence, it is evident that the different bioactive factors of CA offered protection against PTZ-induced epilepsy.

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Effect of modulating glutamate signaling on myelinating oligodendrocytes and their development—A study in the zebrafish model

Turan

Yılmaz

Schünemann

et al. 2021

J of Neuroscience Research

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Erratum: Axo-myelinic neurotransmission: a novel mode of cell signalling in the central nervous system

Abstract: This corrects the article DOI: 10.1038/nrn.2017.128.

Cited by 18 publications

References 1 publication

Protection of Oligodendrocytes Through Neuronal Overexpression of the Small GTPase Ras in Hyperoxia-Induced Neonatal Brain Injury

Protection of Oligodendrocytes Through Neuronal Overexpression of the Small GTPase Ras in Hyperoxia-Induced Neonatal Brain Injury

Untitled

Effect of modulating glutamate signaling on myelinating oligodendrocytes and their development—A study in the zebrafish model

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