Erratum: ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics

Abstract

Nature Communications 8: Article number: 15375 (2017); Published: 25 May 2017; Updated: 11 July 2017 The affiliation details for Yanlei Ma and Yao Zhang are incorrect in this Article. The correct affiliation details for these authors are given below: Yanlei Ma: Department of GI surgery, Shanghai Tenth People's Hospital Affiliated with Tongji University, 301 Yanchang Road, Shanghai 200072, China.

Strength Through Unity: The Power of the Mega-Scaffold MACF1

“…Such a function was demonstrated for the plakin domain of the related Dst (BPAG1), conferring its ability to bind hemidesmosomes ( Koster et al, 2003 ). Although MACF1 was observed to be present at the tight junctions of intestinal epithelium ( Ma et al, 2017 ), the involvement of its plakin domain for this recruitment has yet to be demonstrated. Furthermore, a weak MT-binding affinity has been attributed to the plakin domain of MACF1 ( Karakesisoglou et al, 2000 ), but the biological relevance of this activity will require further investigation.…”

“…Regulation of the cell-cell junction in the intestinal epithelium is essential for the maintenance of the intestinal barrier and a role for MACF1 in that process was established using intestinal conditional knockout mice ( Ma et al, 2017 ; Figure 3C ). Although the terminal differentiation of the gut was not altered by intestinal MACF1 ablation, these mice showed an altered intestinal physiology with an increase of the size of villi and the depth of crypts and a less organized and polarized intestinal epithelium.…”