Erratum: “A Biomonitoring Study of Lead, Cadmium, and Mercury in the Blood of New York City Adults”

McKelvey, Wendy; Gwynn, R. Charon; Jeffery, Nancy; Kass, Daniel; Thorpe, Lorna E.; Garg, Renu; Palmer, Christopher D.; Parsons, Patrick J.

doi:10.1289/ehp.10056a

Cited by 69 publications

(11 citation statements)

References 43 publications

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“…Further studies will be necessary to establish reference ranges to facilitate interpretation of biomonitoring data. Higher FF Hg concentrations among Asian women are detected, consistent with prior reports for blood Hg in this study population [17] and others [38]. We also detect moderate positive correlations between concentrations of FF Hg and blood Hg, and concentrations of FF Cd and blood Cd, although no correlation for FF Pb and blood Pb.…”

Section: Associations Among Metals In Ff Blood and Urine Compartmentssupporting

confidence: 92%

Associations between toxic metals in follicular fluid and in vitro fertilization (IVF) outcomes

Bloom

Kim

Kruger

et al. 2012

J Assist Reprod Genet

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Purpose We previously reported associations between trace concentrations of Hg, Cd and Pb in blood and urine and reproductive outcomes for women undergoing in-vitro fertilization (IVF). Here we assess measurements in single follicular fluid (FF) specimens from 46 women as a presumably more relevant marker of dose for reproductive toxicity. Methods FF specimens were analyzed for Hg, Cd and Pb using sector field-inductively coupled plasma-mass spectrometry (SF-ICP-MS). Variability sources were assessed by nested ANOVA. Multivariable regression was used to evaluate associations for square root transformed metals with IVF outcomes, adjusting for confounders.

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Section: Associations Among Metals In Ff Blood and Urine Compartmentssupporting

confidence: 92%

Associations between toxic metals in follicular fluid and in vitro fertilization (IVF) outcomes

Bloom

Kim

Kruger

et al. 2012

J Assist Reprod Genet

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“…McKelvey et al reported that the mean blood Cd level was 0.79 μg/L in women. 21 In present study, the CM Cd levels were 14.1±3 μg/L and 11.47±3.2 μg/L in the infertile and control groups, respectively. Cervical mucus Cd levels were 14.5±3.2 μg/L, 14.5±3.2 μg/L and 13.3±2.5 μg/L in women with ovulatory disorders, in women with tubal factor and in women with unexplained infertility, respectively.…”

Section: Discussionsupporting

confidence: 45%

“…Our findings were also similar to the blood Pb levels previously reported for infertile cases. 20,21 Cervical mucus Pb levels were 19.3±5.3 μg/L in those with ovulatory disorders, 17.2±5.1 μg/L in those with tubal factors and 15.4±4.3 μg/L in those with unexplained infertility.…”

Section: Discussionmentioning

confidence: 97%

Association of Between Heavy Metal and Trace Element Levels in Blood and Cervical Mucus with Female Infertility

Ilgin¹,

Hassa²,

Karataş³

et al. 2012

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Infertility affects 10-15% of couples during the reproductive period. Ovulatory disorders are more common in younger women whereas unexplained infertility occurs more commonly in older women. Recently, many environmental agents, such as cigarettes, alcohol, heat, electromagnetic energy and radiation have been shown to have negative effects on the reproductive system. Environmental factors and exposure to heavy metals change fertility patterns in adults by affecting germ cell maturation, fertilization and the endocrine system. We aimed to investigate the effect of trace elements and heavy metals in blood and cervical mucus on female infertility. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Study was performed with 50 women: Infertile (n=35) and controls (n=15). Blood and cervical mucus samples were collected to measure Zn, Cu, Cd, and Pb levels. R Re es su ul lt ts s: : Mean blood plasma and cervical mucus Zn, Cd, and Cu levels in the infertile group were significantly lower than those in the control group. Whole blood Pb level was higher in the infertile group compared to the control group. Although blood Cd level tended to be higher in smokers and cervical mucus Cd level tended to be lower in controls, neither of these difference were statistically significant. C Co on nc cl lu us si io on n: : Lower levels of plasma and cervical mucus Zn and Cu were thought to result from higher levels of Cd and Pb in blood and cervical mucus. Abnormal levels of heavy metals in blood and cervical mucus may have adverse effects on the female reproductive function.K Ke ey y W Wo or rd ds s: : Cervix mucus; metals, heavy; trace elements; infertility, female Ö ÖZ ZE ET T A Am ma aç ç: : İnfertilite, üreme çağındaki çiftlerin %10-15' ini etkilemektedir. İleri yaşlarda daha yaygın olarak açıklanamayan infertilite, genç kadınlarda ise ovulatuvar rahatsızlık gözlenmektedir. Son zamanlarda, sigara, alkol, ısı, elektromanyetik enerji ve radyasyon gibi çok sayıda çevresel ajanın üreme sistemine olumsuz etkisi olduğu gösterilmiştir. Çevresel faktörler ve ağır metallere maruz kalma, germ hücre olgunlaşmasını, döllenmeyi ve endokrin sistemi etkileyerek erişkinlerde doğurganlık durumunu etkilemektedir. Bu çalışmada kan ve servikal mucusta eser elementlerin ve ağır metallerin kadın infertilitesi üzerine etkisini araştırmayı amaçladık. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışma 35 infertil ve 15 kontrol, toplam 50 kadın ile gerçekleştirildi. Zn, Cu, Cd ve Pb düzeylerini ölçmek için kan ve servikal mucus örnekleri toplandı. B Bu ul lg gu ul la ar r: : Ortalama kan plazması ve servikal mucus Zn, Cd, ve Cu düzeyleri infertil grupta kontrol grubuna göre anlamlı olarak düşüktü. Tam kan kurşun düzeyi infertil grupta kontrol grubundan daha yüksekti. Sigara içenlerde kan Cd düzeyi daha yüksek ve kontrol grubunda servikal mucus Cd düzeyi daha düşük olma eğiliminde olmasına rağmen, her iki farklılık da istatistiksel olarak anlamlı değildi. S So on nu uç ç: : Plazma...

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“…However, in unexposed populations taken as controls, blood mercury concentration was reported to be 2.73 ng/ mL in New York City adults and 1 ng/mL in China (14,15). For many years mercury was used in diuretics or as an ingredient of antiseptics (4).…”

Section: Mercurymentioning

confidence: 99%

“…Another important mechanism of exposure is fish consumption. Mercury attains 5.65 ng/mL among regular fish consumers (13,14) and levels of 7 to 10 ng/mL among exposed workers (10,15).…”

Section: Mercurymentioning

confidence: 99%

Toxic effects of mercury, lead and gadolinium on vascular reactivity

Vassallo

Simões

Furieri

et al. 2011

Braz J Med Biol Res

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Heavy metals have been used in a wide variety of human activities that have significantly increased both professional and environmental exposure. Unfortunately, disasters have highlighted the toxic effects of metals on different organs and systems. Over the last 50 years, the adverse effects of chronic lead, mercury and gadolinium exposure have been underscored. Mercury and lead induce hypertension in humans and animals, affecting endothelial function in addition to their other effects. Increased cardiovascular risk after exposure to metals has been reported, but the underlying mechanisms, mainly for short periods of time and at low concentrations, have not been well explored. The presence of other metals such as gadolinium has raised concerns about contrast-induced nephropathy and, interestingly, despite this negative action, gadolinium has not been defined as a toxic agent. The main actions of these metals, demonstrated in animal and human studies, are an increase of free radical production and oxidative stress and stimulation of angiotensin I-converting enzyme activity, among others. Increased vascular reactivity, highlighted in the present review, resulting from these actions might be an important mechanism underlying increased cardiovascular risk. Finally, the results described in this review suggest that mercury, lead and gadolinium, even at low doses or concentrations, affect vascular reactivity. Acting via the endothelium, by continuous exposure followed by their absorption, they can increase the production of free radicals and of angiotensin II, representing a hazard for cardiovascular function. In addition, the actual reference values, considered to pose no risk, need to be reducedResearch supported by CAPES and CNPq/FAPES/ FUNCITEC (#39767531/07), Brazil, and MCINN (#SAF 2009-07201) and ISCIII (Red RECAVA, #RD06/0014/0011), Spai

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Erratum: “A Biomonitoring Study of Lead, Cadmium, and Mercury in the Blood of New York City Adults”

Cited by 69 publications

References 43 publications

Associations between toxic metals in follicular fluid and in vitro fertilization (IVF) outcomes

Associations between toxic metals in follicular fluid and in vitro fertilization (IVF) outcomes

Association of Between Heavy Metal and Trace Element Levels in Blood and Cervical Mucus with Female Infertility

Toxic effects of mercury, lead and gadolinium on vascular reactivity

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