Erratum

Gibbs, RB

doi:10.1016/s0006-8993(98)00945-7

Cited by 13 publications

(5 citation statements)

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“…Moreover, there is an increase in dendritic spine density in the hippocampus with higher levels of endogenous E 2 or following E 2 administration to ovariectomized (OVX) rats (Gould et al, 1990; MacLusky et al, 2005; Woolley et al, 1990; Woolley and McEwen, 1993). A similar pattern is found for levels of the trophic factor, brain derived neurotrophic factor (BDNF), in the hippocampus across the estrous cycle and following exogenous E 2 administration (Gibbs, 1998, 1999; Frye and Rhodes, 2005). The proliferative effects of E 2 may also underlie its actions to increase neurogenesis in the hippocampus (reviewed in Galea, 2008).…”

Section: Introductionsupporting

confidence: 54%

Divergent mechanisms for trophic actions of estrogens in the brain and peripheral tissues

et al. 2011

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17β-estradiol (E2) can enhance reproductive, cognitive, and affective functions; however, the mechanisms by which E2 has these effects need to be better understood. Pleiotrophic effects of E2 can occur via traditional and novel actions at various forms of estrogen receptors (ERs). In the central nervous system, trophic effects of E2 may be related to beneficial effects of hormone replacement therapy (HRT). However, in peripheral reproductive tissues, E2's capacity to evoke growth can increase risk of cancers. This review focuses on investigations aimed at elucidating divergent mechanisms of steroids to promote trophic effects in the brain, independent of effects on peripheral reproductive tissues. First, actions of estrogens via ERα or ERβ for peripheral growth (carcinogen-induced tumors, uterine growth) and hippocampus-dependent behaviors (affect, cognition) are described. Second, factors that influence these effects of estrogens are described (e.g. experience, timing/critical windows, non-ER mechanisms). Third, effects of estrogens at ERβ related to actions of progestogens, such as 5α-pregnan-3α-ol-20-one (3α,5α-THP) are described. In summary, effects of E2 may occur via multiple mechanisms, which may underlie favorable effects in the brain with minimal peripheral trophic effects.

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Section: Introductionsupporting

confidence: 54%

Divergent mechanisms for trophic actions of estrogens in the brain and peripheral tissues

et al. 2011

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“…However, another report indicates that the expression of BDNF protein in the hippocampus is induced on the day of proestrus and into estrus (Scharfman et al, 2003). Aware of this discrepancy, the report by Scharfman et al (2003) suggested that the contrasting results reported between their study and that of Gibbs (1998) may be due to methodological differences, since they were measuring BDNF protein, which may be influenced by antibody specificity, while Gibbs measured mRNA (Scharfman et al, 2003). Furthermore, the discrepancy between these studies may also be due to the population of neurons studied.…”

Section: Gonadal Steroid Hormones Regulate Bdnf Expressionmentioning

confidence: 96%

“…Besides the cerebellum, reports also indicate that hippocampal BDNF expression mirrors the changes in estradiol that occur across the estrous cycle in rodents, although inconsistency exists between the various studies. For example, it was reported by one study, which tracked hippocampal Bdnf mRNA using in situ hybridization, that expression of this gene was minimal during late proestrus and into estrus (Gibbs, 1998), shortly after the peak of circulating estradiol. However, another report indicates that the expression of BDNF protein in the hippocampus is induced on the day of proestrus and into estrus (Scharfman et al, 2003).…”

Section: Gonadal Steroid Hormones Regulate Bdnf Expressionmentioning

confidence: 99%

Sex and stress hormone influences on the expression and activity of brain-derived neurotrophic factor

Carbone

Handa

2013

Neuroscience

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The neurotrophin, brain-derived neurotrophic factor (BDNF), is recognized as a key component in the regulation of central nervous system ontogeny, homeostasis and adult neuroplasticity. The importance of BDNF in central nervous system development and function is well documented by numerous reports from animal studies linking abnormal BDNF signaling to metabolic disturbances and anxiety or depressive-like behavior. Despite the diverse roles for BDNF in nearly all aspects of central nervous system physiology, the regulation of BDNF expression, as well as our understanding of the signaling mechanisms associated with this neurotrophin, remains incomplete. However, links between sex hormones such as estradiol and testosterone, as well as endogenous and synthetic glucocorticoids, have emerged as important mediators of BDNF expression and function. Examples of such regulation include brain region-specific induction of Bdnf mRNA in response to estradiol. Additional studies have also documented regulation of the expression of the high-affinity BDNF receptor TrkB by estradiol, thus implicating sex steroids not only in the regulation of BDNF expression, but on mechanisms of signaling associated with it. In addition to gonadal steroids, further evidence also suggests functional interaction between BDNF and glucocorticoids, such as in the regulation of corticotrophin-releasing hormone and other important neuropeptides. In this review, we provide an overview of the roles played by selected sex or stress hormones in the regulation of BDNF expression and signaling in the central nervous system

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“…Likewise, BDNF expression in the hippocampus has been shown to be significantly affected by physiological changes in the levels of circulating E2. 73 , 74 The interaction between BDNF and E2 thus appears to be complex and bidirectional. It should be noted that the estrous cycle of sham-operated mice were not controlled for in the present study and this is a limitation which should be addressed in future investigations.…”

Section: Discussionmentioning

confidence: 99%

Analyzing the influence of BDNF heterozygosity on spatial memory response to 17β-estradiol

Buuse

et al. 2015

Transl Psychiatry

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The recent use of estrogen-based therapies as adjunctive treatments for the cognitive impairments of schizophrenia has produced promising results; however the mechanism behind estrogen-based cognitive enhancement is relatively unknown. Brain-derived neurotrophic factor (BDNF) regulates learning and memory and its expression is highly responsive to estradiol. We recently found that estradiol modulates the expression of hippocampal parvalbumin-positive GABAergic interneurons, known to regulate neuronal synchrony and cognitive function. What is unknown is whether disruptions to the aforementioned estradiol–parvalbumin pathway alter learning and memory, and whether BDNF may mediate these events. Wild-type (WT) and BDNF heterozygous (+/−) mice were ovariectomized (OVX) at 5 weeks of age and simultaneously received empty, estradiol- or progesterone-filled implants for 7 weeks. At young adulthood, mice were tested for spatial and recognition memory in the Y-maze and novel-object recognition test, respectively. Hippocampal protein expression of BDNF and GABAergic interneuron markers, including parvalbumin, were assessed. WT OVX mice show impaired performance on Y-maze and novel-object recognition test. Estradiol replacement in OVX mice prevented the Y-maze impairment, a Behavioral abnormality of dorsal hippocampal origin. BDNF and parvalbumin protein expression in the dorsal hippocampus and parvalbumin-positive cell number in the dorsal CA1 were significantly reduced by OVX in WT mice, while E2 replacement prevented these deficits. In contrast, BDNF+/− mice showed either no response or an opposite response to hormone manipulation in both behavioral and molecular indices. Our data suggest that BDNF status is an important biomarker for predicting responsiveness to estrogenic compounds which have emerged as promising adjunctive therapeutics for schizophrenia patients.

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Erratum

Cited by 13 publications

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Divergent mechanisms for trophic actions of estrogens in the brain and peripheral tissues

Divergent mechanisms for trophic actions of estrogens in the brain and peripheral tissues

Sex and stress hormone influences on the expression and activity of brain-derived neurotrophic factor

Analyzing the influence of BDNF heterozygosity on spatial memory response to 17β-estradiol

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