Erradicación del Helicobacter pylori en pacientes obesos pre-cirugía bariátrica

Abstract

Many bariatric surgeons recommend routine Helicobacter pylori (H. pylori) screening as a part of the workup for bariatric surgery. Some studies suggested that obese patients have a lower eradication rate and the Body Mass Index could be independent risk factor for this failure. Objective. To evaluate the H. pylori eradication of a 14 days Quadruple Concomitant therapy in obese patients undergoing bariatric surgery compared against a control group. Material and Methods. Prospective study included 76 patients undergoing bariatric surgery and 75 control patients with a normal BMI and dyspepsia. Results. In the obese group, the eradication rate was 69% whereas in the control group was 89%. p < 0.05, Odds ratio 3.18 (CI 1.35-7.45). The distribution of age, gender, smoking and diabetes did not differ significantly between the two groups. Conclusions. Obese patients showed a significantly lower eradication of H. pylori than controls to a two weeks Quadruple Concomitant therapy.

Relationship between Obesity Severity and Helicobacter pylori Eradication in patients undergoing bariatric surgery: A Post hoc analysis

“…[12,13,16,19] The data on H. pylori treatment in the context of obesity are very scarce. Early studies by Abdullahi et al [20] and Laudanno et al [14] highlighted a signi cant decrease in eradication rates among overweight and patients with obesity. Abdullahi et al employed classic triple therapy (pantoprazole, clarithromycin, and amoxicillin for 7 days) and included overweight and individuals with obesity, while in the study of Laudanno et al they included only patients with obesity undergoing bariatric surgery, they used the quadruple concomitant regimen for 14 days, yielding equivalent ndings.…”

“…Brie y, the rst study evaluated H. pylori eradication between patients with normal Body Mass Index (BMI) and dyspepsia versus obese patients. [14] The second study assessed H. pylori eradication in obese patients using a standard xed-dose quadruple therapy regimen compared to a weight-adjusted regimen. [15] All obese patients included were scheduled for bariatric surgery.…”