Erradicación de Helicobacter pylori en una población  de alto riesgo de cáncer gástrico

Sierra, Rosa A.; Salas, Pilar; Zúñiga, Francisco Mora; Sanabria, Marjorie; Chinnock, Anne; Peña, Salvador; Quirós, Eber; Mora, Walter Javier Narea; Mena, Fernando; Altman, Rodrigo; Muñóz, Núbia

doi:10.51481/amc.v40i2.588

AMC

2010

DOI: 10.51481/amc.v40i2.588

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Erradicación de Helicobacter pylori en una población de alto riesgo de cáncer gástrico

Rosa A. Sierra

Pilar Salas²,

Francisco Mora Zúñiga³

et al.

Abstract: Erradicación de Helicobacter pylori en pacientes dispépticos de una población de alto riesgo de cáncer gástrico...

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“…A few studies have been carried out in Costa Rica on the relationship between diet and chronic diseases. Data have been published on the prevalence of cardiovascular risk factors 2 , cervical cancer [3][4][5] and gastric cancer [6][7][8][9][10] , which is of special interest as Costa Rica has one of the highest incidence and death rates for this type of cancer in the world 11 .…”

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Validation of a diet history questionnaire for use with Costa Rican adults

Chinnock

2008

Public Health Nutr.

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Objective: To validate a diet history questionnaire (DHQ) using a weighed food record (WFR) as the standard method in the estimation of food consumption and nutrient intake in a group of adults. Design: WFR: all foods consumed by subjects during 7 consecutive days were weighed and recorded by nutrition students. Two DHQ interviews were carried out on days 1 (first diet history questionnaire, DHQ1) and 28 (second diet history questionnaire, DHQ2). Setting: Costa Rica. Subjects: Sixty adults: 30 men and 30 women; 30 living in urban and 30 in rural areas. Results: In comparison to the WFR, the DHQ1 gave statistically significant higher estimates of the mean intake of 19 nutrients for men and of three nutrients for women. The uncorrected correlation coefficients for nutrient intake according to both methods ranged from 0.40 to 0.83 for males and from 0.22 to 0.62 for females. Percentage of subjects classified in the same quartiles of nutrient intake according to each method ranged from 33.3% to 63.3% for males and from 23.3% to 53.3% for females. Misclassification in extreme quartiles ranged from 0% to 13.3% for both sexes. The mean food group consumption, according to the DHQ1, when compared with the WFR, gave statistically significant differences for three of the 18 food groups for men and for two groups in the case of women. The two applications of the DHQ gave similar results. Conclusion: Validation of a DHQ using a WFR as the standard method gave results that compare favourably with those reported by other authors. This study found important differences in the response of men and women to the DHQ: among men, the estimates of mean nutrient intake from DHQ1 were significantly greater than those of the WFR, while in the case of women, the mean nutrient intake estimates from both methods were not significantly different. There was a higher degree of correlation between the DHQ1 and the WFR mean nutrient intakes among men than among women. The DHQ showed good reproducibility. Keywords Diet History Questionnaire Dietary assessment methods Nutritional epidemiologyThe health and nutrition situation of the Costa Rican population is one of transition. The health indicators show a reduction in the incidence of childhood infectious diseases and an increase in chronic diseases among adults 1 , a transformation that is associated, among other things, with changing lifestyle patterns and, more specifically, changes in diet. A few studies have been carried out in Costa Rica on the relationship between diet and chronic diseases. Data have been published on the prevalence of cardiovascular risk factors 2 , cervical cancer 3-5 and gastric cancer 6-10 , which is of special interest as Costa Rica has one of the highest incidence and death rates for this type of cancer in the world 11 .The study of diet in epidemiological research requires methods that measure food consumption over the longer rather than shorter term, which can be applied to groups with different characteristics and not just those who are highly motivated an...

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Validation of a diet history questionnaire for use with Costa Rican adults

Chinnock

2008

Public Health Nutr.

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Association of interleukin-1B and interleukin-1RN polymorphisms with gastric cancer in a high-risk population of Costa Rica

et al. 2005

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Several risk factors have been associated with gastric cancer, among them Helicobacter pylori infection. This bacterium yields inflammation, the degree of which depends on the bacterial strain and the severity of the host response. The inflammatory response involves a complex cytokine network. Recently, polymorphisms of the genes coding for interleukin-1beta (IL-1B), interleukin-1Ra (ILRN) and interleukin-10 have been associated with an increased risk of gastric cancer. In order to determine the association of the IL-1B, IL-1RN and IL-10 polymorphisms with gastric cancer in a high-risk Costa Rican population, we analysed purified DNA of 58 gastric cancer patients, 99 controls and 41 patients classified as group I or II, according to the Japanese classification. Genotyping was carried out by PCR, PCR-RFLP and pyrosequencing analysis. We did not find any association of the IL-1B-31, IL-1B-511 and IL-10 polymorphisms with the risk for developing gastric cancer in the studied population. Carriers of the IL-1B+3954T/- had an increased risk for developing gastric cancer (OR 3.7; 95%CI: 1.34-10.2). Also we found an increased risk for developing gastric cancer for allele 2 heterozygotes of the IL-1RN (OR 2.94; 95%CI: 1.09-7.93). This is the first time that IL-1B+3954 has been associated with gastric cancer. This is one of the first studies trying to describe the role played by IL-1B, IL-1RN and IL-10 genetic polymorphisms in gastric cancer in one of the highest risk American countries. Further investigation on American countries is needed.

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Association of serum pepsinogen with atrophic body gastritis in Costa Rica

et al. 2006

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Individuals with atrophic gastritis (AG), especially atrophic body gastritis (ABG), are at increased risk of developing gastric cancer. Serum concentrations of pepsinogens (PG) have been proposed as markers for ABG. The aim of this study was to determine the risk factors for AG and ABG and the potential of using serum PG concentrations to detect ABG in a dyspeptic population in Costa Rica, which is one of the countries with the highest incidence and mortality rates of gastric cancer in the world. Seven biopsy specimens, a fasting blood sample and a questionnaire concerning sociodemographic factors were obtained from 501 consecutive dyspeptic patients. The serum PGI level and the PGI/PGII ratios were significantly lower in patients with ABG than in other groups (P<0.000). A cut-off point of 3.4 led to a sensitivity of 91.2% in identifying ABG, a negative predictive value of 98.1%, but a positive predictive value of only 11.2%. Helicobacter pylori were present in 93% of the patients and all those with peptic ulcers were positive. AG was associated with increased age, lower body mass index, high alcohol intake and low fruit consumption. ABG was associated with age, alcohol consumption and PGI/PGII<3.4. In dyspeptic patients with a high prevalence of H. pylori infection, serum PG levels provide an assessment of ABG but it is necessary to introduce other serological and genetic markers in order to achieve a better specificity. Those markers could be serum antibodies to H. pylori-CagA, cytokine gene polymorphisms or others.

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Erradicación de Helicobacter pylori en una población de alto riesgo de cáncer gástrico

Abstract: Erradicación de Helicobacter pylori en pacientes dispépticos de una población de alto riesgo de cáncer gástrico...

Cited by 4 publications

References 0 publications

Validation of a diet history questionnaire for use with Costa Rican adults

Validation of a diet history questionnaire for use with Costa Rican adults

Association of interleukin-1B and interleukin-1RN polymorphisms with gastric cancer in a high-risk population of Costa Rica

Association of serum pepsinogen with atrophic body gastritis in Costa Rica

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