ERP evidence of preserved early memory function in term infants with neonatal encephalopathy following therapeutic hypothermia

Pfister, Katie M.; Zhang, Lei; Miller, Neely C.; Hultgren, Solveig; Boys, Chris J.; Georgieff, Michael

doi:10.1038/pr.2016.169

Cited by 5 publications

(10 citation statements)

References 44 publications

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“…We analyzed mean data from adjacent groupings of electrodes ( Figure 1 ) where we noted the most activity to stimuli, in the frontal, central, and posterior (slow wave only) scalp regions. These areas are consistent with the most prominent areas of activity in other studies of newborn auditory recognition memory ( 18 – 20 , 22 ).…”

Section: Methodssupporting

confidence: 90%

“…Both study group and control infants underwent auditory recognition memory assessment via ERP at the University of Minnesota Center for Neurobehavioral Development, as previously described ( 20 ). Infants were targeted for testing at 44 weeks post-conceptual age (i.e.…”

Section: Methodsmentioning

confidence: 99%

“…Data were analyzed using Netstation 4.5.7 analysis software (EGI) as previously described ( 20 ). The two EEG electrodes below the infant’s eyes (channels 62 and 63) and two of the electrodes on the outside canthii of the eyes (channels 61 and 64) were not used to avoid artifact due to blinking; this resulted in the use of recordings from a total of 60 electrodes.…”

Section: Methodsmentioning

confidence: 99%

“…This technique has been widely used by cognitive neuroscientists to study discrimination, attention and memory ( 17 ). Studies of at-risk populations of infants, including preterm infants, infants of diabetic mothers and infants with neonatal encephalopathy, discovered disrupted memory function in the newborn period using ERPs ( 18 – 20 ). These studies showed that recognition memory can be evaluated in very young (newborn) infants and, importantly, that neonatal recognition memory is associated with later cognitive function ( 18 , 21 ).…”

Section: Introductionmentioning

confidence: 99%

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Infants exposed to antibiotics after birth have altered recognition memory responses at one month of age

et al. 2020

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Background: Neonatal exposure to antibiotics, in the absence of infection, results in abnormal learning and memory in animals and is linked to changes in gut microbes. The relevance of early-life antibiotic exposure to brain function in humans is not known. Methods: Recognition memory was assessed at 1 month of age in 15 term-born infants exposed to antibiotics (with negative cultures) and 57 unexposed infants using event-related potentials (ERPs). Linear regression analysis, adjusting for covariates, was employed to compare groups with respect to ERP features representing early stimulus processing (P2 amplitude) and discrimination between mother and stranger voices. Results: Infants exposed to antibiotics exhibited smaller P2 amplitudes for both voice conditions ( p = 0.001), with greatest reductions observed for mother’s voice in frontal and central scalp regions ( p < 0.04). Infants exposed to antibiotics showed larger P2 amplitudes to stranger’s as compared to mother’s voice, a reversal of the typical response exhibited by unexposed infants. Abnormal ERP responses did not consistently correlate with increased inflammatory cytokines within the antibiotic-exposed group. Conclusion: Otherwise healthy infants exposed to antibiotics soon after birth demonstrated altered auditory processing and recognition memory responses, supporting the possibility of a microbiota-gut-brain axis in humans during early life.

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Section: Methodssupporting

confidence: 90%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Infants exposed to antibiotics after birth have altered recognition memory responses at one month of age

et al. 2020

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“…Prior to the advent of TH, studies have shown that children with a history of HIE had poorer working memory, long-term episodic memory, and verbal and visual memory [ 9 , 10 , 11 ]. While some studies have shown continued memory dysfunctions in children with history of HIE even after TH [ 3 , 12 ], our group showed that newborns with HIE who received TH had preservation of recognition memory function at an electrophysiologic level, yet an alteration in the brain circuitry underlying that function at 2 weeks of age [ 13 ].…”

Section: Introductionmentioning

confidence: 92%

Reduced Hippocampal Volumes in Children with History of Hypoxic Ischemic Encephalopathy after Therapeutic Hypothermia

et al. 2023

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Hypoxic ischemic encephalopathy (HIE) remains a significant cause of disability despite treatment with therapeutic hypothermia (TH). Many survive with more subtle deficits that affect daily functioning and school performance. We have previously shown an early indication of hippocampal changes in infants with HIE despite TH. The aim of this study was to evaluate the hippocampal volume via MRI and memory function at 5 years of age. A cohort of children followed from birth returned for a 5-year follow-up (n = 10 HIE treated with TH, n = 8 healthy controls). The children underwent brain MRI and neurodevelopmental testing to assess their brain volume, general development, and memory function. Children with HIE had smaller hippocampal volumes than the controls despite no differences in the total brain volume (p = 0.02). Children with HIE generally scored within the average range on developmental testing. Though there was no difference in the memory scores between these groups, there was a positive within-group correlation between the hippocampal volume and memory scores in children with HIE (sentence recall r = 0.66, p = 0.038). There was no relationship between newborn memory function and 5-year hippocampal size. Children with HIE treated with TH experienced significant and lasting changes to the hippocampus despite improvements in survival and severe disability. Future studies should target diminishing injury to the hippocampus to improve overall outcomes.

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Preserved speed of processing and memory in infants with a history of moderate neonatal encephalopathy treated with therapeutic hypothermia

et al. 2018

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ERP evidence of preserved early memory function in term infants with neonatal encephalopathy following therapeutic hypothermia

Abstract: Infants with NE have preserved recognition memory function after TH. The spatially different recognition memory processing after early brain injury may represent compensatory changes in the brain circuitry and reflect a benefit of TH.

Cited by 5 publications

References 44 publications

Infants exposed to antibiotics after birth have altered recognition memory responses at one month of age

Infants exposed to antibiotics after birth have altered recognition memory responses at one month of age

Reduced Hippocampal Volumes in Children with History of Hypoxic Ischemic Encephalopathy after Therapeutic Hypothermia

Preserved speed of processing and memory in infants with a history of moderate neonatal encephalopathy treated with therapeutic hypothermia

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