Erotomania induced by venlafaxine: a case study

Adamou, Marios; Hale, Anthony S.

doi:10.1034/j.1600-0447.2003.00055_1.x

Cited by 24 publications

(12 citation statements)

References 22 publications

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“…The immediate postpartum period, as in the case of B., illustrates how multiple interacting factors can produce a very special state [24]. The literature on erotomania provides examples of precipitation by antidepressants [25] and other drugs. Alcohol is often involved.…”

Section: Discussionmentioning

confidence: 97%

Erotomania and Recommendations for Treatment

Seeman

2015

Psychiatr Q

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The aim of this paper is to help clinicians better understand how erotomania originates in order to facilitate treatment and make it more effective. Data sources are the narratives of six women who spoke in detail about the beginnings of their delusional beliefs and about the nature of the evidence that convinced them that their beliefs were well-founded. In every case, low self-esteem and emotional arousal preceded the emergence of the delusion. Misperceptions and misattributions appeared responsible for keeping the delusion alive. Despite external disconfirmation, social isolation protected the delusional beliefs from revision and extinction. The erotomanic delusion provided a sense of well-being that probably contributed to its maintenance. As well, a delusion-induced boost in well-being delayed help-seeking. Recommendations for treatment include staged interventions, first establishing a therapeutic alliance with a focus on understanding the psychological factors contributing to the origin and maintenance of the delusion. The next stage is the provision of social support and strategies directed at the restoration of self-esteem. The third stage is the gradual introduction of techniques to correct cognitive biases. Medication and risk management form an integral part of overall management. Objective evidence for the effectiveness of this approach is, however, not yet available.

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Section: Discussionmentioning

confidence: 97%

Erotomania and Recommendations for Treatment

Seeman

2015

Psychiatr Q

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“…Admou and Hale[2] had reported a case where a 39 year-old lady with major depressive disorder developed delusions of love on two separate occasions, on treatment with venlafaxine in the doses of 225-300 mg/day. Each time the delusions remitted after lowering the dose of venlafaxine to 75-150 mg/day.…”

Section: Discussionmentioning

confidence: 99%

“…[1] A case of erotomania in a patient with major depressive disorder when she was put on 225-300 mg/day of venlafaxine was reported by Admou and Hale. [2] Here we report a case where a patient with social phobia developed delusions of persecution when he was treated with venlafaxine 150 mg/day.…”

Section: Introductionmentioning

confidence: 99%

Venlafaxine-induced psychotic symptoms

Safeekh

Pinto

2009

Indian J Psychiatry

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Venlafaxine, an antidepressant belongs to Serotonin Norepinephrine Reuptake Inhibitors (SNRI), blocks the synaptic reuptake of serotonin in lower doses and also blocks reuptake of norepinephrine in higher doses. In addition it also blocks dopamine reuptake in still higher doses. This last mechanism of action is found to cause psychotic symptoms. Very few cases are reported with this adverse effect of venlafaxine. Here is a case report where a 32 year-old male with social phobia developed delusions of persecution on two occasions when he was put on venlafaxine 150 mg/day, which responded to withdrawal of venlafaxine and a short course of antipsychotics. The delusions never reappeared when he was maintained on escitalopram.

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“…Interestingly, in all above case reports the worsening of psychotic symptomatology appeared to be dose-dependent (venlafaxine dose ≥150 mg/day) and in some instances associated with rapid titration of the medication [30]. The psychosis was regulated with either cessation of the medication [27,31] or lowering the dose to 75-150 mg/day [28]. In the current case series, none of our patients developed or had worsening of existing positive symptomatology in the course of their treatment with venlafaxine.…”

Section: Discussionmentioning

confidence: 99%

Antipsychotic Augmentation with Venlafaxine for Treatment of Negative Symptoms in Chronic Schizophrenia - A Case Series

Mukaetova‐Ladinska¹,

Silva²,

Darley³

2010

Macedonian Journal of Medical Sciences

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Negative symptoms represent a core feature in schizophrenia and the deficit syndrome in chronic schizophrenic patients is closely related to their poor outcome and global failure in community adaptation. Atypical antipsychotics have been widely used in the treatment of negative symptoms in schizophrenia, and tend to produce a better response when used in association with antidepressants. We describe a case series of patients with a clinical diagnosis of residual type of schizophrenia, who have undergone an augmentative treatment of antipsychotic medication with venlafaxine. Both primary and secondary negative symptoms, as well as the overall functioning in these patients were substantially improved following this treatment. This is the first clinical study describing the combination of venlafaxine with both conventional antipsychotics and novel antipsychotics, such as risperidone, to treat successfully both secondary and primary negative symptoms in schizophrenia. We also discuss possible modes of action of the joint use of this particular antidepressant with antipsychotic medication.

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Erotomania induced by venlafaxine: a case study

Abstract: Erotomania may occur with agents such as antidepressants. The dopamine neurotransmission of mood can provide further evidence for the development of newer classes of antidepressants.

Cited by 24 publications

References 22 publications

Erotomania and Recommendations for Treatment

Erotomania and Recommendations for Treatment

Venlafaxine-induced psychotic symptoms

Antipsychotic Augmentation with Venlafaxine for Treatment of Negative Symptoms in Chronic Schizophrenia - A Case Series

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