Erosive Lichen Planus of the Vulva and Vagina

Lotery, Helen; Galask, Rudolph P.

doi:10.1097/00006250-200305001-00027

Cited by 10 publications

(13 citation statements)

References 5 publications

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“…O Tacrolimus, a new immunomodulatlng topical agent. calcineurin inhibitor, originally used for atopic dermatitis (6,7), has been administered in other immuno-mcdiated skin diseases (8)(9)(10)(11)(12)(13)(14)(15)(16) and recently also in LS (17)(18)(19)(20).…”

mentioning

confidence: 99%

Vulvar Lichen Sclerosus: 11 Women Treated with Tacrolimus 0.1% Ointment

Lauriola¹,

Mantovani²,

Corazza³

2007

Acta Derm Venereol

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Lichen sclerosus is a chronic relapsing disease, usually treated with ultra-potent corticosteroids. As immunological alterations are considered important aetiopathogenetic factors in lichen sclerosus, the new immunomodulating topical agents, such as tacrolimus and pimecrolimus, have been employed sporadically as alternative therapies. The aim of this study was to evaluate the therapeutic effects of tacrolimus 0.1% ointment in lichen sclerosus in 11 patients unresponsive or poorly responsive to previous treatments. Tacrolimus 0.1% ointment was applied twice daily for 6 weeks, then tapered over a further 6 weeks. Symptoms and objective parameters were evaluated and quantified at the start, after 6 weeks, at the end of the topical treatment, and at follow-up visits. Improvement or remission of symptoms was observed in the patients who completed the study, while objective parameters were poorly influenced and often were not related to symptom behaviour. Topical tacrolimus can be considered an alternative treatment for lichen sclerosus.

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confidence: 99%

Vulvar Lichen Sclerosus: 11 Women Treated with Tacrolimus 0.1% Ointment

Lauriola¹,

Mantovani²,

Corazza³

2007

Acta Derm Venereol

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“…Vulvovaginal LP causes scarring and, as a consequence of this, narrowing of the vagina and labia minora (1, 3), (6, 7), (10). The treatment of stenosing vulvovaginal LP is challenging to the physician, and treatment results are often disappointing.…”

mentioning

confidence: 99%

Treatment of vulvovaginal erosive and stenosing lichen planus by surgical dilatation and methotrexate

Kortekangas-Savolainen

Kiilholma

2007

Acta Obstet Gynecol Scand

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“…Experience from 35 patients in six studies suggests that tacrolimus is an effective second‐line treatment for steroid‐resistant GLP 1–6 . In our experience tacrolimus may be poorly tolerated due to local burning or stinging.…”

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confidence: 75%