ERN as a transdiagnostic marker of the internalizing-externalizing spectrum: A dissociable meta-analytic effect

Pasion, Rita; Barbosa, Fernando

doi:10.1016/j.neubiorev.2019.06.013

Cited by 86 publications

(96 citation statements)

References 149 publications

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“…The ERN is an early signal for performance adaptations after an error occurred (Ullsperger et al, 2014), implying that the HBW group is associated with enhanced performance monitoring. This contrasts with prior reports of reduced ERN amplitudes in addictive behaviors (Franken et al, 2018;Littel et al, 2012;Zhou et al, 2013) and is interesting in light of recent meta-analytic evidence that increased vs. decreased ERN may be a risk-marker for internalizing vs. externalizing disorders, respectively (Pasion & Barbosa, 2019).…”

Section: Discussioncontrasting

confidence: 80%

“…The reduction of ERN amplitudes has further been observed in substance use disorders and suggested as a potential endophenotype (Euser et al, 2013;Luijten et al, 2014). A recent meta-analysis concluded that the reduction of ERN may reliably dissociate internalizing vs. externalizing disorders and could represent a marker for this dissociation (Pasion & Barbosa, 2019). Furthermore, the ERN is influenced by motivational factors such as reward and punishment as a function of task performance or task context (Endrass et al, 2010;Hajcak et al, 2005;Potts, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Neural correlates of response inhibition and performance monitoring in binge watching

Kilian

Bröckel

Overmeyer

et al. 2019

Preprint

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With the increasing popularity of internet streaming portals, the question why people develop bingewatching behavior has become a focus of scientific research and its addictive potential is discussed.The current study examined neural correlates of binge-watching during inhibition in a go/nogo task and performance monitoring using electroencephalography. Participants reported high binge-watching behavior (HBW, n = 35) or no binge-watching (NBW, n = 33) episode during the past four weeks.Compared to the NBW group, HBW showed larger P3 during response inhibition and larger error-related negativity (ERN) for errors in the flanker task. Group differences in behavioral measures were not observed. The current results suggest that binge watching may be related to both (1) increased neural recruitment during response inhibition as indicated by the increased P3 to facilitate normal inhibitory performance and (2) enhanced performance monitoring as indicated by the increased ERN. As this neurocognitive profile differs from observations in other addictive and excessive behaviors, implications for this budding field are discussed.

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Section: Discussioncontrasting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Neural correlates of response inhibition and performance monitoring in binge watching

Kilian

Bröckel

Overmeyer

et al. 2019

Preprint

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“…This year, several authors have highlighted the potential for a transdiagnostic framework at reconciling the broad range of ERN patterns in the literature (Gillan et al, 2017;Pasion and Barbosa, 2019;Riesel, 2019). The present paper is timely, being the first study to apply an expansive and empirically robust transdiagnostic approach that directly addresses the issue of co-occurring symptoms in a large sample.…”

Section: Discussionmentioning

confidence: 86%

“…Likewise, the trend was for alcohol addiction to be associated with a blunted ERN, consistent with the previous literature. Recent reviews add support to this conclusion: two meta-analyses noted that overall effect sizes for anxiety or OCD traits for enhanced ERN were relatively small (Cavanagh and Shackman, 2015;Pasion and Barbosa, 2019) and another that assessed the effect size of ERN amplitude shifts in OCD (Riesel, 2019) noted that larger effect sizes were associated with smaller sample publications, suggesting publication bias.…”

Section: Discussionmentioning

confidence: 98%

“…Particularly for the enhanced ERN, anxious apprehension (Moser et al, 2013) or uncertainty (Cavanagh and Shackman, 2015) are key candidates, supported by studies in non-clinical samples demonstrating that increased levels of worry (Hajcak et al, 2003b;Moser et al, 2012;Zambrano-Vazquez and Allen, 2014) and threat sensitivity (Weinberg et al, 2016) are associated with larger ERNs. That said, grouplevel effects in OCD patients tend to be more robust than in generalised anxiety disorder (Endrass and Ullsperger, 2014;Santesso et al, 2006), with a recent metaanalysis positing a higher effect size for OCD than anxiety (Pasion and Barbosa, 2019). As only a few studies have attempted to disentangle (and control for) intercorrelated symptoms within individuals in the same sample, and even fewer have done this in a sample of sufficient size, it remains to be seen if enhancements in the ERN confer risk for anxiety, compulsive symptoms or both.…”

Section: Introductionmentioning

confidence: 99%

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Null results from a dimensional study of error-related negativity (ERN) and self-reported psychiatric symptoms

Seow

Benoit

Dempsey

et al. 2019

Preprint

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Alterations in error processing are implicated in a range of DSM-defined psychiatric disorders. For instance, obsessive-compulsive disorder (OCD) and generalised anxiety disorder show enhanced electrophysiological responses to errors -i.e. errorrelated negativity (ERN) -while others like schizophrenia have an attenuated ERN.However, as diagnostic categories in psychiatry are heterogeneous and also highly intercorrelated, the precise mapping of ERN enhancements and impairments is unclear. To address this, we recorded electroencephalograms (EEG) from 196 participants who performed the Flanker task and collected scores on 9 questionnaires assessing psychiatric symptoms to test if a dimensional framework could reveal specific transdiagnostic clinical manifestations of error processing dysfunctions. Contrary to our hypothesis, we found no association between ERN amplitude and symptom severity of OCD, trait anxiety, depression, social anxiety, impulsivity, eating disorders, alcohol addiction, schizotypy or apathy. A transdiagnostic approach did nothing to improve signal; there was no association between three transdiagnostic dimensions (anxious-depression, compulsive behaviour and intrusive thought and social withdrawal) and ERN magnitude. In these same individuals, we replicated a previously published transdiagnostic association between goal-directed learning and compulsive behaviour and intrusive thought.Associations between the ERN and psychopathology might be smaller than previously assumed and/or dependent on a greater level of symptom severity than other transdiagnostic cognitive biomarkers.

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The moderating role of externalizing problems on the association between anxiety and the error‐related negativity in youth

Suor

Granros

Kujawa

et al. 2020

Developmental Psychobiology

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The error‐related negativity (ERN) is an event‐related potential that reflects error monitoring. Enhanced ERN indicates sensitivity to performance errors and is a correlate of anxiety disorders. In contrast, youth with externalizing problems exhibit a reduced ERN, suggesting decreased error monitoring. Anxiety and externalizing problems commonly co‐occur in youth, but no studies have tested how comorbidity might modulate the ERN. In a sample of youth (N = 46, ages 7–19) with and without anxiety disorders, this preliminary study examined the interactive effect of anxiety and externalizing problems on ERN. Results suggest that externalizing problems moderate the relation between anxiety symptoms and ERN in youth. Anxious youth with less externalizing problems exhibited enhanced ERN response to errors. Conversely, anxious youth with greater externalizing problems demonstrated diminished ERN in response to errors. The regions of significance and proportion affected tests indicated that the moderating the effect of externalizing problems was only significant for youth with anxiety disorders. Findings suggest that enhanced neural error sensitivity could be a specific neurophysiological marker for anxiety disorders, whereas anxious individuals with comorbid externalizing problems demonstrate reduced error monitoring, similar to those with primary externalizing pathology. Results underscore the utility of examining neural correlates of pediatric anxiety comorbidity subtypes.

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ERN as a transdiagnostic marker of the internalizing-externalizing spectrum: A dissociable meta-analytic effect

Cited by 86 publications

References 149 publications

Neural correlates of response inhibition and performance monitoring in binge watching

Neural correlates of response inhibition and performance monitoring in binge watching

Null results from a dimensional study of error-related negativity (ERN) and self-reported psychiatric symptoms

The moderating role of externalizing problems on the association between anxiety and the error‐related negativity in youth

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