Abstract:Invadopodia are actin‐rich membrane protrusions which have been assigned essential roles in cancer cell invasiveness. Here, we investigate the roles of ezrin, radixin and moesin (ERM), three closely related F‐actin‐plasma membrane linker proteins implicated in metastasis, and their binding partner the Na+/H+ exchanger isoform 1 (NHE1), in the formation and function of invadopodial rosettes in MCF‐7 human breast cancer cells. ERM proteins colocalized strongly with NHE1 in invadopodia in MCF‐7 cells +/− constitu… Show more
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