Erlotinib conjugated gold nanocluster enveloped magnetic iron oxide nanoparticles–A targeted probe for imaging pancreatic cancer cells

Nebu, John; Devi, J.S. Anjali; Aparna, R.S.; Abha, Km.; George, Sony

doi:10.1016/j.snb.2017.11.017

Cited by 32 publications

(12 citation statements)

References 38 publications

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“…To assess the impact of pH value on the cellular uptake and drug release of DOX-loaded NPs, the fluorescence of DOX in super-pH-sensitive DOX@MSN-ss-DTPP&DTCPP NPs was detected, and the images were shown in Figure . From the bright field images, the normal morphology of HeLa cells could be observed, which was regarded as an important proof in determining the cellular state . The fluorescence field images (blue and red) revealed the normal morphology of cellular nuclear and the intracellular uptake of DOX, respectively.…”

Section: Resultsmentioning

confidence: 93%

“…From the bright field images, the normal morphology of HeLa cells could be observed, which was regarded as an important proof in determining the cellular state. 42 The fluorescence field images (blue and red) revealed the normal morphology of cellular nuclear and the intracellular uptake of DOX, respectively. Moreover, the biocompatibility of drug-loaded NPs toward cells and intracellular uptake of DOX were further demonstrated by the overlapped images of bright field image and fluorescence field images.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

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Super-pH-Sensitive Mesoporous Silica Nanoparticle-Based Drug Delivery System for Effective Combination Cancer Therapy

Cheng

Qin

et al. 2019

ACS Biomater. Sci. Eng.

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A multifunctional nanoplatform based on mesoporous silica nanoparticles (MSNs) was developed for combinational tumor therapy. Doxorubicin (DOX) was chosen as an antitumor drug and loaded into mesopores of MSNs via physical absorption. Then, a tumor-targeted fusion peptide conjugated with 2,3-dimethylmaleic anhydride (DTCPP) and a therapeutic peptide conjugated with 2,3-dimethylmaleic anhydride (DTPP) were introduced to the surface of MSNs as super-pH-sensitive nanovalves through disulfide linkages. The BSA adsorption assay confirmed the charge-reversal property of MSN-ss-DTPP&DTCPP nanoparticles at slightly acidic condition (pH 6.8) and superior stability in physiological environment (pH 7.4). According to the drug release research, both glutathione (GSH) and acidic condition are required for the accelerated drug release from DOX@MSN-ss-DTPP&DTCPP nanoparticles. Moreover, in vitro studies demonstrated the significantly reinforced tumor cellular uptake efficiency and mitochondrial disruption ability of DOX@MSN-ss-DTPP&DTCPP nanoparticles in tumor environment, in which DOX@MSN-ss-DTPP&DTCPP nanoparticles exhibited the preferred cytotoxicity toward αvβ3-positive human cervical carcinoma (HeLa) cells. We believe that the multifunctional dual-stimuli-sensitive MSN could provide an effective strategy for combinational tumor therapy.

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Section: Resultsmentioning

confidence: 93%

Section: ■ Experimental Sectionmentioning

confidence: 99%

Super-pH-Sensitive Mesoporous Silica Nanoparticle-Based Drug Delivery System for Effective Combination Cancer Therapy

Cheng

Qin

et al. 2019

ACS Biomater. Sci. Eng.

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“…Compliment activation, cytokine production [27] Gold NP-tagged toxin MCF-7 Down-regulation of CDK-4 and MAPK [39] Au@ZIF-8 NPs EMT-6 murine breast cancer cell ROS generation [53] Fe3O4@AuNC@erlotinib PANC-1 Selective targeting of overexpressed EGFR [62] GOx…”

Section: Type Of Nanoparticles/nano-conjugatesmentioning

confidence: 99%

Nanoparticles in Clinical Translation for Cancer Therapy

Mundekkad

Cho

2022

IJMS

122

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The advent of cancer therapeutics brought a paradigm shift from conventional therapy to precision medicine. The new therapeutic modalities accomplished through the properties of nanomaterials have extended their scope in cancer therapy beyond conventional drug delivery. Nanoparticles can be channeled in cancer therapy to encapsulate active pharmaceutical ingredients and deliver them to the tumor site in a more efficient manner. This review enumerates various types of nanoparticles that have entered clinical trials for cancer treatment. The obstacles in the journey of nanodrug from clinic to market are also reviewed. Furthermore, the latest developments in using nanoparticles in cancer therapy are also highlighted.

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“…synthesized erlotinib‐conjugated iron oxide‐Au NCs core‐shell nanocomposite for targeted optical and MR dual‐imaging and drug delivery. [ 295 ] Zhou et al. applied amphiphilic polymer‐coated iron oxide NPs to encapsulate DOX and conjugate IGF1.…”

Section: Pdac‐tailored Theranostic Nanomaterials For Imaging‐guided Tmentioning

confidence: 99%

Tailor‐Made Nanomaterials for Diagnosis and Therapy of Pancreatic Ductal Adenocarcinoma

Xia

Lee

et al. 2021

Advanced Science

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Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers worldwide due to its aggressiveness and the challenge to early diagnosis and treatment. In recent decades, nanomaterials have received increasing attention for diagnosis and therapy of PDAC. However, these designs are mainly focused on the macroscopic tumor therapeutic effect, while the crucial nano–bio interactions in the heterogeneous microenvironment of PDAC remain poorly understood. As a result, the majority of potent nanomedicines show limited performance in ameliorating PDAC in clinical translation. Therefore, exploiting the unique nature of the PDAC by detecting potential biomarkers together with a deep understanding of nano–bio interactions that occur in the tumor microenvironment is pivotal to the design of PDAC‐tailored effective nanomedicine. This review will introduce tailor‐made nanomaterials‐enabled laboratory tests and advanced noninvasive imaging technologies for early and accurate diagnosis of PDAC. Moreover, the fabrication of a myriad of tailor‐made nanomaterials for various PDAC therapeutic modalities will be reviewed. Furthermore, much preferred theranostic multifunctional nanomaterials for imaging‐guided therapies of PDAC will be elaborated. Lastly, the prospects of these nanomaterials in terms of clinical translation and potential breakthroughs will be briefly discussed.

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Erlotinib conjugated gold nanocluster enveloped magnetic iron oxide nanoparticles–A targeted probe for imaging pancreatic cancer cells

Cited by 32 publications

References 38 publications

Super-pH-Sensitive Mesoporous Silica Nanoparticle-Based Drug Delivery System for Effective Combination Cancer Therapy

Super-pH-Sensitive Mesoporous Silica Nanoparticle-Based Drug Delivery System for Effective Combination Cancer Therapy

Nanoparticles in Clinical Translation for Cancer Therapy

Tailor‐Made Nanomaterials for Diagnosis and Therapy of Pancreatic Ductal Adenocarcinoma

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