Erk5 functions in modulation of zebrafish intestinal permeability

Lv, Haimei; Jin, Ziwei; Wang, Dongxia; Guo, Xiaoling; Wang, Haihe; Yang, Shulan

doi:10.1007/s00441-023-03786-2

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2024

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“…Lv et al identified a significant function of ERK5 in zebrafish, revealing its crucial role in intestinal development and integrity maintenance. In zebrafish larvae, the knockout of erk5 results in underdeveloped intestinal walls and increased permeability [109]. Additionally, ERK5 exacerbates tobacco smoke-induced gastric epithelial-to-mesenchymal transition in mice, a process reversible through ERK5 inhibition [143].…”

Section: Other Tissuesmentioning

confidence: 99%

Bone and Extracellular Signal-Related Kinase 5 (ERK5)

Wen,

Liu,

Zhou

et al. 2024

Biomolecules

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Bones are vital for anchoring muscles, tendons, and ligaments, serving as a fundamental element of the human skeletal structure. However, our understanding of bone development mechanisms and the maintenance of bone homeostasis is still limited. Extracellular signal-related kinase 5 (ERK5), a recently identified member of the mitogen-activated protein kinase (MAPK) family, plays a critical role in the pathogenesis and progression of various diseases, especially neoplasms. Recent studies have highlighted ERK5’s significant role in both bone development and bone-associated pathologies. This review offers a detailed examination of the latest research on ERK5 in different tissues and diseases, with a particular focus on its implications for bone health. It also examines therapeutic strategies and future research avenues targeting ERK5.

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Section: Other Tissuesmentioning

confidence: 99%