ERK3/MAPK6 promotes triple-negative breast cancer progression through collective migration and EMT plasticity
Sofia Morazzo,
Soraia Fernandes,
Marina Fortea
et al.
Abstract:Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer and is associated with high cell plasticity, recurrence, and metastatic rate. During epithelial-to-mesenchymal transition (EMT), cancer cells display EMT plasticity, or partial-EMT features, which are required for breast cancer metastasis, such as collective migration. ERK3 has been implicated in promoting migration and invasion of breast cancer, but the mechanisms remain elusive. Here, we investigated ERK3 expression across p… Show more
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