ERK1-mediated immunomodulation of mesenchymal stem cells ameliorates inflammatory disorders

Zhang, Qing; Lei, Xiao; Wang, Fang; He, Xiaoning; Liu, Lu; Hou, Yuxia; Liu, Yuan; Jin, Fang; Chen, Chider; Li, Bei

doi:10.1016/j.isci.2023.107868

Cited by 2 publications

(1 citation statement)

References 48 publications

(63 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 14 , 16 , 23 ] Its involvement in the regulation of endometrial stem cell fate decisions, including maintenance of pluripotency and promotion of survival, renders it a critical component of the cellular response to external cues, including antigen exposure. [ 15 ] Furthermore, the Akt [ 24 ] and ERK1/2 [ 25 ] signaling pathways play a vital role in modulating the immune response, adding another layer of relevance to its investigation in the context of stem cell memory functions. By focusing on these pathways, our study leverages their established biological importance to elucidate the mechanisms underlying stem cell memory functions.…”

Section: Discussionmentioning

confidence: 99%

Exploring Memory Function Beyond Immune Cells: ANGPTL4‐Mediated Memory Functions in Tissue Resident Stem Cells

Park,

Min,

Kim

et al. 2024

Advanced Science

View full text Add to dashboard Cite

Adapted immune cells are known to develop memory functions that increase resistance to subsequent infections after initial pathogen exposure, however, it is unclear whether non‐immune cells, like tissue‐resident stem cells, have similar memory functions. Here, it is found that tissue‐resident stem cells crucial for tissue regeneration show diminished adverse effects on diverse stem cell functions against successive exposure to foreign antigen (β‐glucan) to maintain tissue homeostasis and stability both in vitro and in vivo. These data suggest that endometrial stem cells may possess a robust memory function, in contrast, fully differentiated cells like fibroblasts and vesicular cells do not show these memory mechanisms upon consecutive antigen exposure. Moreover, the pivotal role of Angiopoietin‐like 4 (ANGPTL4) in regulating the memory functions of endometrial stem cells is identified through specific shRNA knockdown in vitro and knockout mice in vivo experiments. ANGPTL4 is associated with the alteration of diverse stem cell functions and epigenetic modifications, notably through histone H3 methylation changes and two pathways (i.e., PI3K/Akt and FAK/ERK1/2 signaling) upon consecutive antigen exposure. These findings imply the existence of inherent self‐defense mechanisms through which local stem cells can adapt and protect themselves from recurrent antigenic challenges, ultimately mitigating adverse consequences.

show abstract