ERK1/2 inhibition disrupts alcohol memory reconsolidation and prevents relapse
Nofar Rahamim,
Mirit Liran,
Coral Aronovici
et al.
Abstract:Relapse to alcohol abuse after periods of abstinence, often caused by cue-induced alcohol craving, is a major challenge in the treatment of alcohol addiction. Therefore, disruption of the cue-alcohol associative memories can diminish the risk of relapse. Upon retrieval, memories become temporarily labile before they reconsolidate in a process that requires protein synthesis. Accumulating evidence suggests that the mammalian target of rapamycin complex 1 (mTORC1), which is responsible for the translation of a s… Show more
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