ERK-dependent brain-derived neurotrophic factor regulation by hesperidin in mice exposed to chronic mild stress

Li, Cheng-Fu; Chen, Shao-Mei; Mu, Rong-Hao; Wang, Shuangshuang; Geng, Di; Liu, Qing; Yi, Long

doi:10.1016/j.brainresbull.2016.03.016

Cited by 34 publications

(27 citation statements)

References 50 publications

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“…These authors concluded that the antidepressant effect of hesperidin is mediated by inhibition of L-arginine-NO-cGMP pathway and by an increase of the BDNF levels in the hippocampus. In another examination, Li et al [ 41 ] explored the antidepressant-like mechanism of hesperidin in mice exposed to chronic mild stress (CMS). The obtained results showed the ability of hesperidin to ameliorate the reduction of sucrose preference and reverse the augmented immobility time induced by CMS.…”

Section: Resultsmentioning

confidence: 99%

Antidepressant Flavonoids and Their Relationship with Oxidative Stress

Hrițcu

Ionita

Postu

et al. 2017

Oxidative Medicine and Cellular Longevity

102

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Depression is a serious disorder that affects hundreds of millions of people around the world and causes poor quality of life, problem behaviors, and limitations in activities of daily living. Therefore, the search for new therapeutic options is of high interest and growth. Research on the relationship between depression and oxidative stress has shown important biochemical aspects in the development of this disease. Flavonoids are a class of natural products that exhibit several pharmacological properties, including antidepressant-like activity, and affects various physiological and biochemical functions in the body. Studies show the clinical potential of antioxidant flavonoids in treating depressive disorders and strongly suggest that these natural products are interesting prototype compounds in the study of new antidepressant drugs. So, this review will summarize the chemical and pharmacological perspectives related to the discovery of flavonoids with antidepressant activity. The mechanisms of action of these compounds are also discussed, including their actions on oxidative stress relating to depression.

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Section: Resultsmentioning

confidence: 99%

Antidepressant Flavonoids and Their Relationship with Oxidative Stress

Hrițcu

Ionita

Postu

et al. 2017

Oxidative Medicine and Cellular Longevity

102

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“…Xu et al [198] tested the total phenol fraction of H. citrina using a CUMS model and described a potential mechanism mediated by regulation of neurotransmitters and BDNF levels in the brain and alleviation of both the corticosterone levels and oxidative stress [198]. The flavonoid hesperidin has also been shown to exert an antidepressant-like effect mediated in an ERK-dependent manner [199]. Hibiscus rosasinensis decreased the immobility time (TST and FST) and attenuated the duration of immobility induced by D 2 and α 1 antagonists, and acted as an 5-HT inhibitor synthesis in both tests.…”

Section: Dosementioning

confidence: 99%

Medicinal Plants in the Treatment of Depression: Evidence from Preclinical Studies

Moragrega

Rı́os

2021

Planta Med

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Medicinal plants and their extracts are natural remedies with enormous potential for treating various diseases, including depression and anxiety. In the case of depression, hundreds of plants have traditionally been used in folk medicine for generations. Different plant extracts and natural products have been analyzed as potential antidepressant agents with validated models to test for antidepressant-like effects in animals, although other complementary studies have also been employed. Most of these studies focus on the possible mediators implicated in these potential effects, with dopamine, serotonin, and noradrenaline being the principal neurotransmitters implicated, both through interference with receptors and with their metabolism by monoamino oxidases, as well as through neuro-endocrine and neuroprotective effects. There are approximately 650 reports of antidepressant-like medicinal plants in PubMed; 155 of them have been compiled in this review, with a relevant group yielding positive results. Saffron and turmeric are the most relevant species studied in both preclinical and clinical studies; St. Johnʼs wort or kava have also been tested extensively. To the best of our knowledge, no review to date has provided a comprehensive understanding of the biomolecular mechanisms of action of these herbs or of whether their potential effects could have real benefits. The purpose of this narrative review is to provide an update regarding medicinal plants from the year 2000 to the present to examine the therapeutic potential of these antidepressant-like plants in order to contribute to the development of new therapeutic methods to alleviate the tremendous burden that depression causes worldwide.

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“…Corticosterone levels in the plasma were quantified using an ELISA kit following the manufacturer's instructions (Enzo Life Sciences). [18][19][20][21]…”

Section: Dexamethasone-loaded Microspheres Systemic Effectsmentioning

confidence: 99%

Controlled dexamethasone delivery via double-walled microspheres to enhance long-term adipose tissue retention

et al. 2017

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Current materials used for adipose tissue reconstruction have critical shortcomings such as suboptimal volume retention, donor-site morbidity, and poor biocompatibility. The aim of this study was to examine a controlled delivery system of dexamethasone to generate stable adipose tissue when mixed with disaggregated human fat in an athymic mouse model for 6 months. The hypothesis that the continued release of dexamethasone from polymeric microspheres would enhance both adipogenesis and angiogenesis more significantly when compared to the single-walled microsphere model, resulting in long-term adipose volume retention, was tested. Dexamethasone was encapsulated within single-walled poly(lactic-co-glycolic acid) microspheres (Dex SW MS) and compared to dexamethasone encapsulated in a poly(lactic-co-glycolic acid) core surrounded by a shell of poly-l-lactide. The double-walled polymer microsphere system in the second model was developed to create a more sustainable drug delivery process. Dexamethasone-loaded poly(lactic-co-glycolic acid) microspheres (Dex SW MS) and dexamethasone-loaded poly(lactic-co-glycolic acid)/poly-l-lactide double-walled microspheres (Dex DW MS) were prepared using single and double emulsion/solvent techniques. In vitro release kinetics were determined. Two doses of each type of microsphere were examined; 50 and 27 mg of Dex MS and Dex DW MS were mixed with 0.3 mL of human lipoaspirate. Additionally, 50 mg of empty MS and lipoaspirate-only controls were examined. Samples were analyzed grossly and histologically after 6 months in vivo. Mass and volume were measured; dexamethasone microsphere-containing samples demonstrated greater adipose tissue retention compared to the control group. Histological analysis, including hematoxylin and eosin and CD31 staining, indicated increased vascularization (p < 0.05) within the Dex MS-containing samples. Controlled delivery of adipogenic factors, such as dexamethasone via polymer microspheres, significantly affects adipose tissue retention by maintaining healthy tissue formation and vascularization. Dex DW MS provide an improved model to former Dex SW MS, resulting in notably longer release time and, consequently, larger volumes of adipose retained in vivo. The use of microspheres, specifically double-walled, as vehicles for controlled drug delivery of adipogenic factors therefore present a clinically relevant model of adipose retention that has the potential to greatly improve soft tissue repair.

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ERK-dependent brain-derived neurotrophic factor regulation by hesperidin in mice exposed to chronic mild stress

Cited by 34 publications

References 50 publications

Antidepressant Flavonoids and Their Relationship with Oxidative Stress

Antidepressant Flavonoids and Their Relationship with Oxidative Stress

Medicinal Plants in the Treatment of Depression: Evidence from Preclinical Studies

Controlled dexamethasone delivery via double-walled microspheres to enhance long-term adipose tissue retention

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