Eritema necrolítico migratorio asociado a glucagonoma

Bosch‐Amate, Xavier; Riera‐Monroig, Josep; Fernández, Pilar Iranzo

doi:10.1016/j.medcli.2019.06.027

Cited by 1 publication

(3 citation statements)

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“…The typical skin lesion (the dermatosis) induced by a glucagonoma is a rash called necrolytic migratory erythema (NME) which is most frequently seen at disease onset (1)(2)(3). Insulin-dependent diabetes mellitus, depression, diarrhoea, deep vein thrombosis are also identified, as parts of so-called 'D' syndrome (4)(5)(6). Severe intestinal transit damage causes malnutrition in association with glucose metabolism anomalies (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

“…Insulin-dependent diabetes mellitus, depression, diarrhoea, deep vein thrombosis are also identified, as parts of so-called 'D' syndrome (4)(5)(6). Severe intestinal transit damage causes malnutrition in association with glucose metabolism anomalies (4)(5)(6). Typical glucagonoma triad includes NME, diabetes and weight loss (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

“…Severe intestinal transit damage causes malnutrition in association with glucose metabolism anomalies (4)(5)(6). Typical glucagonoma triad includes NME, diabetes and weight loss (4)(5)(6). Also infections such as stomatitis has been reported in some subjects (7,8).…”

Section: Introductionmentioning

confidence: 99%

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Glucagonoma: From skin lesions to the neuroendocrine component (Review)

et al. 2020

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Glucagonoma is a hormonally active rare pancreatic neuroendocrine tumour causing an excess of glucagon. This is a narrative review based on a multidisciplinary approach of the tumour. Typically associated dermatosis is necrolytic migratory erythema (NME) which is most frequently seen at disease onset. Insulin-dependent diabetes mellitus, depression, diarrhoea, deep vein thrombosis are also identified, as parts of so-called 'D' syndrome. Early diagnosis is life saving due to potential aggressive profile and high risk of liver metastasis. NME as paraneoplastic syndrome may be present for months and even years until adequate recognition and therapy; it is remitted after successful pancreatic surgery. Thus the level of practitioners' awareness is essential. If surgery is not curative, debulking techniques may improve the clinical aspects and even the outcome in association with other procedures such as embolization of hepatic metastasis; ablation of radiofrequency type; medical therapy including chemotherapy, targeted therapy with mTOR inhibitors such as everolimus, PRRT (peptide receptor radiotherapy), and somatostatin analogues (including combinations of medical treatments). Increased awareness of the condition involves multidisciplinary practitioners.

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