Eriodictyol stimulates insulin secretion through cAMP/PKA signaling pathway in mice islets

Hameed, Abdul; Hafizur, Rahman M.; Hussain, Nusrat; Raza, Sayed Ali; Rehman, Mujeeb; Ashraf, Sajda; Ul-Haq, Zaheer; Khan, Faisal; Abbas, Ghulam; Choudhary, M. Iqbal

doi:10.1016/j.ejphar.2017.12.015

Cited by 38 publications

(15 citation statements)

References 22 publications

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“…At 16.7 mM glucose, the insulin-secretory activity of control islets was 18.8 ± 3.0 ng islet -1 h -1 . A similar value has been reported earlier (Hameed et al, 2018). Among the compounds tested at a single concentration (200 µM), 1,9,12,14,19,20 did not show any effect on the secretion of insulin.…”

Section: Determination Of the Ability Of The Compounds To Enhance Relsupporting

confidence: 92%

Stimulation of insulin secretion by 5-methylcoumarins and its sulfur analogues isolated from Clutia lanceolata Forssk

et al. 2020

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Section: Determination Of the Ability Of The Compounds To Enhance Relsupporting

confidence: 92%

Stimulation of insulin secretion by 5-methylcoumarins and its sulfur analogues isolated from Clutia lanceolata Forssk

et al. 2020

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“…Eriodictyol, present in lemon fruits, significantly controls obesity and diabetes [141]. Recently, eriodictyol was identified as a novel insulin secretagogue in vitro and in vivo which exerts an exclusive glucose-dependent insulinotropic activity via a cAMP/PKA pathway [142]. Moreover, in diabetic rats, eriodictyol supplementation can effectively suppress oxidative stress [143].…”

Section: Anti-diabetic Effects Of Selected Flavonoidsmentioning

confidence: 99%

Flavonoids and Their Anti-Diabetic Effects: Cellular Mechanisms and Effects to Improve Blood Sugar Levels

et al. 2019

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Diabetes mellitus (DM) is a prevailing global health metabolic disorder, with an alarming incidence rate and a huge burden on health care providers. DM is characterized by the elevation of blood glucose due either to a defect in insulin synthesis, secretion, binding to receptor, or an increase of insulin resistance. The internal and external factors such as obesity, urbanizations, and genetic mutations could increase the risk of developing DM. Flavonoids are phenolic compounds existing as secondary metabolites in fruits and vegetables as well as fungi. Their structure consists of 15 carbon skeletons and two aromatic rings (A and B) connected by three carbon chains. Flavonoids are furtherly classified into 6 subclasses: flavonols, flavones, flavanones, isoflavones, flavanols, and anthocyanidins. Naturally occurring flavonoids possess anti-diabetic effects. As in vitro and animal model’s studies demonstrate, they have the ability to prevent diabetes and its complications. The aim of this review is to summarize the current knowledge addressing the antidiabetic effects of dietary flavonoids and their underlying molecular mechanisms on selected pathways: Glucose transporter, hepatic enzymes, tyrosine kinase inhibitor, AMPK, PPAR, and NF-κB. Flavonoids improve the pathogenesis of diabetes and its complications through the regulation of glucose metabolism, hepatic enzymes activities, and a lipid profile. Most studies illustrate a positive role of specific dietary flavonoids on diabetes, but the mechanisms of action and the side effects need more clarification. Overall, more research is needed to provide a better understanding of the mechanisms of diabetes treatment using flavonoids.

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“…Eriodictyol is a natural flavonoid that possesses antidiabetic activity. Hameed et al () reported that eriodictyol improves glucose tolerance and enhances plasma insulin in nondiabetic and diabetic rats. Blood glucose in diabetic rats is reduced after chronic treatment with eriodictyol.…”

Section: Discussionmentioning

confidence: 99%

Eriodictyol inhibits high glucose‐induced extracellular matrix accumulation, oxidative stress, and inflammation in human glomerular mesangial cells

Bai

Wang

Zhu

et al. 2019

Phytotherapy Research

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Diabetic nephropathy (DN) is one of the major complications of diabetes mellitus. The progression of DN has been found to be associated with high glucose (HG)-induced oxidative stress and inflammation in diabetes mellitus. Eriodictyol is a flavonoid that possesses antioxidant and anti-inflammatory effects. However, the effect of eriodictyol on DN remains unknown. In the present study, we evaluated the role of eriodictyol in mesangial cells (MCs) in response to HG condition. The results showed that eriodictyol repressed cell proliferation of HG-stimulated MCs. Treatment with eriodictyol attenuated oxidative stress, which was evidenced by increased superoxide dismutase activity as well as decreased production of reactive oxygen species (ROS) and malondialdehyde.Besides, eriodictyol suppressed the expressions of two NADPH oxidase (NOX) isoforms, NOX2 and NOX4, which are responsible for the generation of ROS. Eriodictyol suppressed the production of extracellular matrix proteins including fibronectin and Collagen IV, as well as the secretion of inflammatory cytokines including TNF-α, IL-1β, and IL-6 in HG-induced MCs. Moreover, the HG-induced activation of Akt/NF-κB pathway was mitigated by eriodictyol. In conclusion, eriodictyol protected MCs from HG stimulation though inhibition of Akt/NF-κB pathway.

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Eriodictyol stimulates insulin secretion through cAMP/PKA signaling pathway in mice islets

Cited by 38 publications

References 22 publications

Stimulation of insulin secretion by 5-methylcoumarins and its sulfur analogues isolated from Clutia lanceolata Forssk

Stimulation of insulin secretion by 5-methylcoumarins and its sulfur analogues isolated from Clutia lanceolata Forssk

Flavonoids and Their Anti-Diabetic Effects: Cellular Mechanisms and Effects to Improve Blood Sugar Levels

Eriodictyol inhibits high glucose‐induced extracellular matrix accumulation, oxidative stress, and inflammation in human glomerular mesangial cells

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