Eriodictyol protects against H2O2-induced neuron-like PC12 cell death through activation of Nrf2/ARE signaling pathway

Lou, Haiyan; Xu, Jing; Ren, Dongmei; Wei, Xinbing; Zhang, Xiumei

doi:10.1016/j.neuint.2012.05.013

Cited by 65 publications

(57 citation statements)

References 22 publications

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“…Etyol is a flavonoid isolated from the Chinese herb Dracocephalum rupestre that has antiinflammatory [13] and antioxidant properties [14,15].…”

Section: Discussionmentioning

confidence: 99%

“…Eriodictyol (Etyol) is a flavonoid, "flavanone", (3′,4′,5,7-tetrahydroxyflavanone) isolated from the Chinese herb (Dracocephalum rupestre) and citrus fruits. There is evidence for its antiinflammatory, anti-allergenic, antimicrobial, anti-cancer [13] and antioxidant properties [14,15]. Eriodictyol reduced nitric oxide (NO) and pro-inflammatory cytokines in LPSstimulated Raw 264.7 cells and suppressed the phagocytic activity of activated macrophages.…”

Section: Introductionmentioning

confidence: 99%

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Neuroinflammatory response to experimental stroke is inhibited by eriodictyol

Ferreira

Fernandes

Lima

et al. 2016

Behavioural Brain Research

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“…Etyol is a flavonoid isolated from the Chinese herb Dracocephalum rupestre that has antiinflammatory [13] and antioxidant properties [14,15].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neuroinflammatory response to experimental stroke is inhibited by eriodictyol

Ferreira

Fernandes

Lima

et al. 2016

Behavioural Brain Research

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“…Eriodictyol, one of the main flavonoids isolated from the Chinese herb Dracocephalum rupestre, has been reported to protect human adult pigment epithelial (ARPE-19) cells against oxidative stress through its effects on Nrf2 activation and changes in phase II gene expression [10]. Our recent study also showed that it protected PC12 cells against H 2 O 2 -induced oxidative stress [11]. However, whether it was also protective in Ab-induced oxidative cell damage remains unknown.…”

Section: Introductionmentioning

confidence: 93%

Eriodictyol Attenuates β-Amyloid 25–35 Peptide-Induced Oxidative Cell Death in Primary Cultured Neurons by Activation of Nrf2

Shi

Zhu³

et al. 2015

Neurochem Res

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Oxidative stress plays an important role in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD). Eriodictyol, a flavonoid isolated from the Chinese herb Dracocephalum rupestre, has long been established as an antioxidant. The present study was designed to investigate the effect of eriodictyol on β-amyloid 25-35 peptide (Aβ25-35)-induced oxidative cell death in primary neurons and to explore the role of the nuclear factor erythroid-2-related factor 2/antioxidant response element (Nrf2/ARE) pathway in this process. For this purpose, primary cultures of cortical neurons were exposed to 15 μM Aβ25-35 in the absence or presence of eriodictyol (20, 40 and 80 μM). The results revealed that Aβ25-35-induced cytotoxicity and apoptotic characteristics such as activation of JNK/p38 apoptotic signaling pathway were effectively attenuated by eriodictyol pretreatment. Eriodictyol treatment also resulted in an increase in Nrf2 protein levels and subsequent activation of ARE pathway genes in primary cultured neurons. The protective effects of eriodictyol were attenuated by RNA interference-mediated knockdown of Nrf2 expression. Taken together, these results clearly demonstrate that eriodictyol protects neurons against Aβ25-35-induced cell death partially through Nrf2/ARE signaling pathway, which further supports that eriodictyol might be a promising novel therapeutic agent for AD.

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“…Eriodictyol is a strong flavonoid extracted from Eriodictyon californicium and is also called as California yerba santa [4]. It exhibits well-known antioxidant, anti-inflammatory, antineoplastic, antimicrobial, and antinociception activities ( Fig.1) [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Computational Studies on Different Types of Apoptotic Proteins Docked With a Dietary Flavonoid Eriodictyol in Colon Cancer

Palani

Natesan

Vaiyapuri

2016

Asian J Pharm Clin Res

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Objective: In this study, to evaluate the computational studies of eriodictyol docked with apoptotic proteins.Methods: AutoDock Vina and Molecular Graphics Laboratory tools were used to determine the interaction between proteins and eriodictyol. Discovery studio visualizer and PyMOL were used to determine the interaction of amino acid residues between apoptotic proteins and eriodictyol. Results:The obtained results revealed more binding affinities of p53, caspase 8, B-cell lymphoma (Bcl)-2, Bcl-2 -associated X protein (BAX), and adenomatous polyposis coli (APC) of −10.6, −10.9, −9.0, −9.5, and 7.2 kcal/mol, respectively. Interaction of hydrophobic polar contacts of amino acid residues of p53 (CYS-277 and ALA-276), caspase 8 [THR-467, THR-337 (2), and GLU-396 (2)], Bcl-2 [ARG-103 (3), ALA-104 (2), and PHE-105, TYR-101], BAX [GLY-108, TRY-107, ASN-106, and GLN-155 (2)], and APC [GLU-40 (2) and LEU-37 (2)] were notified between macromolecules and small molecules. The calculation of root-mean-square deviation of proteins and eriodictyol showed the lower binding energies to be 11.6, 12.5, 15.9, 19.6, and 15.8 and the upper binding energies to be 12.4, 15.3, 16.9, 20.7, and 18, respectively. The homology of binding energies was determined below 2Å which is computationally less expensive and easily determined the hydrophobic polar contacts. Conclusions:The homology of binding energies was determined below 2Å which is computationally less expensive and easily determined the hydrophobic polar contacts. The results were proved that the eriodictyol highly interacted with apoptotic proteins. It might be a strong anti-inflammatory activity of colon cancer. In future, computational molecular docking studies should aid further in vitro and in vivo studies.

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Eriodictyol protects against H2O2-induced neuron-like PC12 cell death through activation of Nrf2/ARE signaling pathway

Cited by 65 publications

References 22 publications

Neuroinflammatory response to experimental stroke is inhibited by eriodictyol

Neuroinflammatory response to experimental stroke is inhibited by eriodictyol

Eriodictyol Attenuates β-Amyloid 25–35 Peptide-Induced Oxidative Cell Death in Primary Cultured Neurons by Activation of Nrf2

Computational Studies on Different Types of Apoptotic Proteins Docked With a Dietary Flavonoid Eriodictyol in Colon Cancer

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