Eriodictyol, a plant flavonoid, attenuates LPS-induced acute lung injury through its antioxidative and anti-inflammatory activity

Abstract

Abstract. Acute lung injury (ALI) is characterized by excessive inflammatory responses and oxidative injury in the lung tissue. It has been suggested that anti-inflammatory or antioxidative agents could have therapeutic effects in ALI, and eriodictyol has been reported to exhibit antioxidative and anti-inflammatory activity in vitro. The aim of the present study was to investigate the effect of eriodictyol on lipopolysaccharide (LPS)-induced ALI in a mouse model. The mice were divided into four groups: Phosphate-buffered saline-treated healthy control, LPS-induced ALI, vehicle-treated ALI (LPS + vehicle) and eriodictyol-treated ALI (LPS + eriodictyol). Eriodictyol (30 mg/kg) was administered orally once, 2 days before the induction of ALI. The data showed that eriodictyol pretreatment attenuated LPS-induced ALI through its antioxidative and anti-inflammatory activity. Furthermore, the eriodictyol pretreatment activated the nuclear factor erythroid-2-related factor 2 (Nrf2) pathway in the ALI mouse model, which attenuated the oxidative injury and inhibited the inflammatory cytokine expression in macrophages. In combination, the results of the present study demonstrated that eriodictyol could alleviate the LPS-induced lung injury in mice by regulating the Nrf2 pathway and inhibiting the expression of inflammatory cytokines in macrophages, suggesting that eriodictyol could be used as a potential drug for the treatment of LPS-induced lung injury.

Viscum articulatumBurm. f.: a review on its phytochemistry, pharmacology and traditional uses

“…Anti-HIV [2] N/A b-amyrin acetate N/A Anticonvulsant, anti-inflammatory, antinociceptive, antioxidant, antidyslipidaemic [101][102][103] Naringenin 7-O-b-Dglucopyranoside N/A Anti-inflammatory, antioxidant, antiviral, hypoglycaemic, hypolipidaemic, pesticide, hypocholesterolaemic, antifungal, antibacterial [101,104,105] Naringenin N/A Enzyme inhibitors, antioxidants, anticancer, anti-inflammatory, hypocholesterolaemic, antibacterial, hepatoprotective, anti-HIV, antispasmodic, antitumour, antiviral, antiulcer, antileukemic, neuroprotective, antihepatotoxic, antifungal [101] Eriodictyol N/A Anti-inflammatory, antibacterial, antioxidant, antiperoxidant, cancer-preventive, aphidifuge, antifeedant, Anti-osteoclastogenic, antagonist, antinociceptive [101,[106][107][108][109][110][111] N/A, not available. [80] Anti-inflammatory WP OA from methanol extract 1-10 lg/ml FMLP and PMA-induced superoxide anion generation by human neutrophil OA inhibited the superoxide anion generation in response to fMLP [86] L, S 11 phytocompounds from ethanol extract [85] number of OH groups in B-ring of flavanones plays a crucial role in radical scavenging activity.…”

Eriodictyol inhibits high glucose‐induced oxidative stress and inflammation in retinal ganglial cells

“…10,11 In addition, it has been reported that eriodictyol attenuates early retinal and plasma abnormalities in streptozotocin-induced diabetic rats. 10,11 In addition, it has been reported that eriodictyol attenuates early retinal and plasma abnormalities in streptozotocin-induced diabetic rats.…”

Naringenin ameliorates LPS-induced acute lung injury through its anti-oxidative and anti-inflammatory activity and by inhibition of the PI3K/AKT pathway

“…The inflammatory response is initiated, amplified and regulated by a complex network of cytokines and other pro-inflammatory cytokines (3). Pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6 and macrophage inflammatory protein 2 (MIP2) have been demonstrated to have a role in the pathogenesis of ALI (4). Exaggerated neutrophilic infiltration is responsible for the damage of alveolar-capillary barrier (5), resulting in the non-cardiogenic pulmonary edema.…”