Erinacine D, a Stimulator of NGF-Synthesis, From the Mycelia of Hericium Erinaceum

Enantioselective Total Synthesis of Cyathin A3.

“…A renewed interest in this class of natural products was initiated by the discovery that members of the erinacine and scabronines class stimulate the biosynthesis of nerve growth factor (NGF). [9][10][11][12][13]17,[20][21][22][23][24] In a bioassay using mouse astroglial cells in the presence of erinacines A, B, and C, the amounts of NGF detected in the culture medium were four fold, two fold, and five fold higher than in the presence of epinephrine, a known potent NGF stimulator used as a positive control-compound in the assay.…”

“…Erinacines [9][10][11]17 were isolated from Hericium erinaceum and striatins were isolated from the mycelium of the basidiomycete C. striatus strain No.12.…”

“…1,7 More recently, several fungal metabolites with structures closely related to those of the cyathins have been reported. Kawagishi [9][10][11] isolated the analogous erinacines from Hericium erinaceum. The scabronines [12][13][14] and sarcodonins 15 have been isolated from Sarcodon scabrosus.…”

Solid State Cultivation of Hericium erinaceus Biomass and Erinacine: A Production

“…Several of them, i.e. erinacines A-H, are known to have a potent stimulating effect on Nerve Growth Factor (NGF) synthesis in vitro [6][7][8][9][10][11][12].…”

Neurite outgrowth stimulatory effects of myco­synthesized AuNPs from Hericium erinaceus (Bull.: Fr.) Pers. on pheochromocytoma (PC-12) cells

“…12 Similarly, Erinacine D isolated from the mycelium of H. erinaceus acted as a stimulator of NGF synthesis. 13 Because of the poor regenerative capacity of CNS, other methods like drugs, gene therapy, stem cells therapy, and nanotechnology continue to be very active with significant clinical potential. However, many of these factors are highmolecular-weight polypeptides, which cannot cross the blood-brain barrier (BBB).…”