2014
DOI: 10.3389/fchem.2014.00076
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Ergovaline stability in tall fescue based on sample handling and storage methods

Abstract: Ergovaline is an ergot alkaloid produced by the endophyte Neotyphodium coenophialum (Morgan-Jones and Gams) found in tall fescue [Schedonorus arundinacea (Schreb.) Dumort.] and blamed for a multitude of livestock disorders. Ergovaline is known to be unstable and affected by many variables. The objective of this study was to determine the effect of sample handling and storage on the stability of ergovaline in tall fescue samples. Fresh tall fescue was collected from a horse farm in central Kentucky at three har… Show more

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Cited by 15 publications
(17 citation statements)
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“…An analytical standard was not available for ergovaline, so quantitation was performed using another ergopeptine, ergotamine, which is not naturally produced by the endophyte [30]. Ergot alkaloids, including ergotamine, are susceptible to epimerization [14,47,48]. The extent of epimerization depends on many variables including light, heat and the amount of time the compound has been dissolved in solution [47,49].…”
Section: Discussionmentioning
confidence: 99%
“…An analytical standard was not available for ergovaline, so quantitation was performed using another ergopeptine, ergotamine, which is not naturally produced by the endophyte [30]. Ergot alkaloids, including ergotamine, are susceptible to epimerization [14,47,48]. The extent of epimerization depends on many variables including light, heat and the amount of time the compound has been dissolved in solution [47,49].…”
Section: Discussionmentioning
confidence: 99%
“…Variations in ergot alkaloid type and concentration in the live plant [ 18 , 19 ] and in harvested plants [ 20 ] that are available for consumption will contribute to a varied alkaloid dose, but not necessarily account for the multiplicity of effects that have been generally attributed to ergotism in livestock. Rather, this diversity of effects is due to an interruption of a number of different biological processes by ergot alkaloids.…”
Section: Ergot Alkaloid Activitymentioning
confidence: 99%
“…One of the most common classes of mycotoxins associated with N. coenophialum include ergot alkaloids, in which toxicity is typically characterized within livestock by reduced weight gain and volatile fatty acid absorption, restricted blood flow, and reduced reproductive rates ( 7 , 8 ). Ergovaline is the main ergopeptine alkaloid produced in the endophyte-infected tall fescue, and is considered the primary causative agent of fescue toxicosis in livestock ( 9 , 10 ). It has been proposed that mechanistically, the structure of ergot alkaloids enables these compounds to act as sympathetic monoamine mimetics for host receptors ( 11 ).…”
Section: Introductionmentioning
confidence: 99%