Ergothioneine Mitigates Telomere Shortening under Oxidative Stress Conditions

Samuel, Priscilla; Tsapekos, Menelaos; Pedro, Nuria de; Liu, Ann; Lippmeier, J. Casey; Chen, Steven

doi:10.1080/19390211.2020.1854919

Cited by 20 publications

(12 citation statements)

References 41 publications

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“…Ergothioneine not only demonstrates excellent antioxidant activity with mitochondrial DNA protection 9 but also protects against telomere shortening under oxidative stress. 28 Oleuropein, a known anti-oxidant, has also shown efficacy against UV irradiation, 29 and stimulates autophagic and proteasome activity for replacement of damaged proteins. 30 Centella asiatica is well known as an antioxidant, 31 but in addition, it has shown activity in wound healing, scar prevention, and fibroblast senescence.…”

Section: Discussionmentioning

confidence: 99%

Antioxidants with proven efficacy and elastin‐conserving vitamin C—A new approach to free radical defense

Widgerow,

Ziegler,

Garruto

et al. 2023

J of Cosmetic Dermatology

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BackgroundThis paper describes the background research and validation related to the formulation of a novel antioxidant product. Two defined outcomes were sought. Firstly, a combined efficacy of antioxidant ingredients in quenching free oxygen radicals. Secondly, the investigation into whether a vitamin C derivative sodium salt was elastin conserving in contrast to current vitamin C/l‐ascorbic acid variations that have been reported to negatively affect elastin constitution and regeneration.Materials and MethodsA leading l‐ascorbic acid antioxidant available on the market was compared with the experimental new product in two studies. In the first experiment, the products were compared to assess their antioxidant properties. The evaluated products TOPICAL ANTIOXIDANT 1 and TOPICAL ANTIOXIDANT 2 were applied to human skin cultures (25–30 mg/cm2) for a total of 72 h of treatment and exposed to oxidative stress. The generation of free radicals was semi‐quantitatively assessed by measuring the fluorescence intensity of the deacetylation and oxidation of the probe dichlorofluorescein diacetate (DCFH‐DA). In the second experiment, an ex vivo skin model (derived from patients undergoing facelift procedures) was used to assess elastin preservation. Three skin explants were topically subjected to the two formulations daily for 7 days. The skin was then prepared and fixed for immunofluorescent assessment after staining with CD44 and tropoelastin antibodies. Images were then analyzed using ImageJ.ResultsA full description of the different components selected for the new formulation is presented. In the first study, the experimental formulation performed with absolute equivalence to the comparator in its radical quenching capacity; both showed extremely effective antioxidant function. In the second study, the comparator negatively affected the existing elastin with areas of breakdown and diminished staining. In contrast, the new formulation showed good conservation of healthy elastin in all sections demonstrating elastin preservation.ConclusionA new antioxidant formulation was carefully designed with multiple actives that show an equivalent antioxidant capacity to a leading product on the market. More importantly, the vitamin C component shows direct elastin conservation and improvement as opposed to the comparator, which had negative effects on elastin preservation. This is in keeping with little‐known literature reports on vitamin C and its negative effects on elastin and validates the use of a sodium salt derivative, which appears to have protective effects on elastin. These findings support the overall regenerative extracellular matrix changes seen with TriHex® technology in other products.

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Section: Discussionmentioning

confidence: 99%

Antioxidants with proven efficacy and elastin‐conserving vitamin C—A new approach to free radical defense

Widgerow,

Ziegler,

Garruto

et al. 2023

J of Cosmetic Dermatology

View full text Add to dashboard Cite

show abstract

“…Increasing evidence has been gathered that shows that the long-term effects of radiation exposure are due to oxidative changes leading to the continuous accumulation of DNA damage in the progeny of both irradiated and non-irradiated bystander cells and that telomeres are a key player in radiation-induced carcinogenesis [ 112 ]. According to a more recent paper by Samuel, ergothioneine has been shown to mitigate telomere shortening under oxidative stress conditions [ 113 ]. As such, we suggest additional research, both at the bench and in a clinical setting, to determine the potential utility of the use of L-ergothioneine as a treatment option for CFIDS patients.…”

Section: Discussionmentioning

confidence: 99%

A Proposed New Model to Explain the Role of Low Dose Non-DNA Targeted Radiation Exposure in Chronic Fatigue and Immune Dysfunction Syndrome

Cocchetto

Seymour

Mothersill

2023

IJMS

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Chronic Fatigue and Immune Dysfunction Syndrome (CFIDS) is considered to be a multidimensional illness whose etiology is unknown. However, reports from Chernobyl, as well as those from the United States, have revealed an association between radiation exposure and the development of CFIDS. As such, we present an expanded model using a systems biology approach to explain the etiology of CFIDS as it relates to this cohort of patients. This paper proposes an integrated model with ionizing radiation as a suggested trigger for CFIDS mediated through UVA induction and biophoton generation inside the body resulting from radiation-induced bystander effects (RIBE). Evidence in support of this approach has been organized into a systems view linking CFIDS illness markers with the initiating events, in this case, low-dose radiation exposure. This results in the formation of reactive oxygen species (ROS) as well as important immunologic and other downstream effects. Furthermore, the model implicates melanoma and subsequent hematopoietic dysregulation in this underlying process. Through the identification of this association with melanoma, clinical medicine, including dermatology, hematology, and oncology, can now begin to apply its expansive knowledge base to provide new treatment options for an illness that has had few effective treatments.

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“…Again, it was proved that EGT could facilitate adjuvant vaccine immunotherapy by modulating the tumor microenvironment . Recently, Samuel et al have reported that EGT mitigates telomere shortening under oxidative stress conditions. Additionally, the EGT concentration in the plasma of patients with CD was remarkably lower than that in the healthy group, , indicating the potential role of EGT.…”

Section: Introductionmentioning

confidence: 99%

l-Ergothioneine Exhibits Protective Effects against Dextran Sulfate Sodium-Induced Colitis in Mice

et al. 2022

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Background : Ulcerative colitis (UC) is a chronic disease of the intestinal tract in which excessive activation of inflammatory response is correlated. l -Ergothioneine (EGT) widely existing in mushrooms has various physiological activities. In this study, the protective effects of EGT on dextran sulfate sodium (DSS)-induced colitis mice were investigated. Results : It was observed that EGT administration, especially at the high dose level, prevented the body weight loss, the colon shortening, and the increase in disease activity index and spleen index caused by DSS. Moreover, EGT supplementation attenuated DSS-induced gut barrier damage by enhancing the expression of tight-junction protein and recovering the loss of gut mucus layer. Furthermore, EGT considerably decreased the colonic myeloperoxidase (MPO) activity induced by DSS, but no significant differences were observed in the concentrations of IL-6 and TNF-α in colon tissues. Additionally, EGT downregulated the populations of CD4 + T cells and macrophages, indicating that EGT stabilized the immune response caused by DSS. Conclusion : Together these results suggest that EGT can alleviate DSS-induced colitis and provide important insights concerning the potential anticolitis activity of such food products.

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Ergothioneine Mitigates Telomere Shortening under Oxidative Stress Conditions

Cited by 20 publications

References 41 publications

Antioxidants with proven efficacy and elastin‐conserving vitamin C—A new approach to free radical defense

Antioxidants with proven efficacy and elastin‐conserving vitamin C—A new approach to free radical defense

A Proposed New Model to Explain the Role of Low Dose Non-DNA Targeted Radiation Exposure in Chronic Fatigue and Immune Dysfunction Syndrome

l-Ergothioneine Exhibits Protective Effects against Dextran Sulfate Sodium-Induced Colitis in Mice

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