Ergothioneine levels in an elderly population decrease with age and incidence of cognitive decline; a risk factor for neurodegeneration?

Cheah, Irwin K.; Feng, Lei; Tang, Richard Ming Yi; Lim, Keith H.C.; Halliwell, Barry

doi:10.1016/j.bbrc.2016.07.074

Cited by 110 publications

(118 citation statements)

References 34 publications

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“…We recently identified that plasma ET levels were significantly lower in elderly subjects with mild cognitive impairment relative to age-matched healthy individuals [27]. Likewise, a similar decline in blood ET was seen in patients with Parkinson disease relative to age-matched healthy individuals [69].…”

Section: Ergothioneine a Viable Therapeutic For Neurodegeneration?mentioning

confidence: 81%

“…While the physiological function of ET remains elusive, studies suggest that ET may function as an antioxidant and cytoprotectant [18,[23][24][25][26]. Our recent study identified that plasma levels of ET were significantly lower in individuals with mild cognitive impairment, leading us to suggest that declining ET levels may be a potential risk factor for dementia [27]. Indeed, numerous studies have shown that ET can be neuroprotective, e.g.…”

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confidence: 99%

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Inhibition of amyloid‐induced toxicity by ergothioneine in a transgenic Caenorhabditis elegans model

Cheah

et al. 2019

FEBS Letters

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The abnormal accumulation of β‐amyloid peptide (Aβ) is recognized as a central component in the pathogenesis of Alzheimer disease. While many aspects of Aβ‐mediated neurotoxicity remain elusive, Aβ has been associated with numerous underlying pathologies, including oxidative and nitrosative stress, inflammation, metal ion imbalance, mitochondrial dysfunction, and even tau pathology. Ergothioneine (ET), a naturally occurring thiol/thione‐derivative of histidine, has demonstrated antioxidant and neuroprotective properties against various oxidative and neurotoxic stressors. This study investigates ET’s potential to counteract Aβ‐toxicity in transgenic Caenorhabditis elegans overexpressing a human Aβ peptide. The accumulation of Aβ in this model leads to paralysis and premature death. We show that ET dose‐dependently reduces Aβ‐oligomerization and extends the lifespan and healthspan of the nematodes.

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Section: Ergothioneine a Viable Therapeutic For Neurodegeneration?mentioning

confidence: 81%

mentioning

confidence: 99%

Inhibition of amyloid‐induced toxicity by ergothioneine in a transgenic Caenorhabditis elegans model

Cheah

et al. 2019

FEBS Letters

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“…While humans are unable to synthesize ET, it can be readily absorbed from diet (main source is mushrooms) and actively accumulated in the body and the brain via a specific transporter, OCTN1 [19][20][21][22]. Our recent study in elderly Singaporeans revealed that plasma levels of ET in participants with MCI were significantly lower than age-matched healthy individuals [23], leading us to believe that a deficiency in ET may be a risk factor for neurodegeneration, and increase ET intake through mushroom consumption might possibly promote cognitive health.…”

Section: Discussionmentioning

confidence: 97%

The Association between Mushroom Consumption and Mild Cognitive Impairment: A Community-Based Cross-Sectional Study in Singapore

Feng

Cheah

et al. 2019

JAD

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We examined the cross-sectional association between mushroom intake and mild cognitive impairment (MCI) using data from 663 participants aged 60 and above from the Diet and Healthy Aging (DaHA) study in Singapore. Compared with participants who consumed mushrooms less than once per week, participants who consumed mushrooms >2 portions per week had reduced odds of having MCI (odds ratio = 0.43, 95% CI 0.23-0.78, p = 0.006) and this association was independent of age, gender, education, cigarette smoking, alcohol consumption, hypertension, diabetes, heart disease, stroke, physical activities, and social activities. Our cross-sectional data support the potential role of mushrooms and their bioactive compounds in delaying neurodegeneration.

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“…In humans, plasma ET levels were found to be significantly decreased in subjects with mild cognitive impairment and Parkinson disease when compared to age‐matched controls. This could happen by multiple mechanisms of course, such as changes in diet and/or OCTN1 transporter activity.…”

Section: Ergothioneine As a Potential Treatment For Diseasesmentioning

confidence: 99%

Ergothioneine – a diet‐derived antioxidant with therapeutic potential

2018

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Ergothioneine is a thiol/thione molecule synthesised only by some fungi and bacteria. Nonetheless, it is avidly taken up from the diet by humans and other animals through a transporter, OCTN1, and accumulates to high levels in certain tissues. Ergothioneine is not rapidly metabolised, or excreted in urine and is present in many, if not all, human tissues and body fluids. Ergothioneine has powerful antioxidant and cytoprotective properties in vitro and there is evidence that the body may concentrate it at sites of tissue injury by raising OCTN1 levels. Decreased blood and/or plasma levels of ergothioneine have been observed in some diseases, suggesting that a deficiency could be relevant to the disease onset or progression. This brief Review explores the possible roles of ergothioneine in human health and disease.

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Ergothioneine levels in an elderly population decrease with age and incidence of cognitive decline; a risk factor for neurodegeneration?

Cited by 110 publications

References 34 publications

Inhibition of amyloid‐induced toxicity by ergothioneine in a transgenic Caenorhabditis elegans model

Inhibition of amyloid‐induced toxicity by ergothioneine in a transgenic Caenorhabditis elegans model

The Association between Mushroom Consumption and Mild Cognitive Impairment: A Community-Based Cross-Sectional Study in Singapore

Ergothioneine – a diet‐derived antioxidant with therapeutic potential

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