Ergothioneine exhibits longevity-extension effect in <i>Drosophila melanogaster via</i> regulation of cholinergic neurotransmission, tyrosine metabolism, and fatty acid oxidation

Pan, Hongyu; Ye, Zhi‐Wei; Zheng, Qianwang; Fan, Yun; Tu, Ming-Zhen; Hong, Wei-Guo; Chen, Bai‐Xiong; Guo, Li‐Qiong; Lin, Jizhen

doi:10.1039/d1fo02758a

Cited by 13 publications

(13 citation statements)

References 53 publications

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“…One of the components of the mushroom extracts is ergothioneine (ET), which is known for its effect on lifespan extension [ 75 , 76 ]. It should be noted that, in our extracts, ET concentration was about 0.1% (1.31 mg/g and 0.99 mg/g in the extracts of H. erinaceus and G. frondosa , respectively).…”

Section: Discussionmentioning

confidence: 99%

Anti-Aging and Neuroprotective Properties of Grifola frondosa and Hericium erinaceus Extracts

et al. 2022

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Nutrition has relevant consequences for human health and increasing pieces of evidence indicate that medicinal mushrooms have several beneficial effects. One of the main issues in Western countries is represented by the challenges of aging and age-related diseases, such as neurodegenerative disorders. Among these, Parkinson’s disease (PD) affects 10 million people worldwide and is associated with α-synuclein misfolding, also found in other pathologies collectively called synucleinopathies. Here, we show that aqueous extracts of two edible mushrooms, Grifola frondosa and Hericium erinaceus, represent a valuable source of β-glucans and exert anti-aging effects in yeast. Their beneficial effects are mediated through the inhibition of the Ras/PKA pathway, with increased expression of heat shock proteins, along with a consistent increase of both mean and maximal lifespans. These fungal extracts also reduce the toxicity of α-synuclein heterologously expressed in yeast cells, resulting in reduced ROS levels, lower α-synuclein membrane localization, and protein aggregation. The neuroprotective activity of G. frondosa extract was also confirmed in a PD model of Drosophila melanogaster. Taken together, our data suggest the use of G. frondosa and H. erinaceus as functional food to prevent aging and age-related disorders, further supporting the neuro-healthy properties of these medicinal mushroom extracts.

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Section: Discussionmentioning

confidence: 99%

Anti-Aging and Neuroprotective Properties of Grifola frondosa and Hericium erinaceus Extracts

et al. 2022

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“…Similarly, OCTN-1 has a higher expression level in the mitochondria, implying that EGT plays a significant role in mitochondria. As shown in Figure 2 , EGT can regulate NOXs [ 82 , 83 ], NADH oxidase [ 31 , 80 , 84 ], and GSH-Px [ 84 ]. Therefore, we inferred that OCTN-1 specifically transports EGT into the mitochondria to remove generated intracellular ROS and alleviate the aging process.…”

Section: The Biological Effect Of Ergothioneinementioning

confidence: 99%

“…Increase in GSH results in a corresponding increase in the ratio of GSH/GSSG [ 31 ]. Pan et al [ 83 ] confirmed that EGT can maintain the ratio of GSH/GSSG and increase lifespan in Drosophila .…”

Section: The Biological Effect Of Ergothioneinementioning

confidence: 99%

Safe and Effective Antioxidant: The Biological Mechanism and Potential Pathways of Ergothioneine in the Skin

et al. 2023

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Ergothioneine, a sulfur-containing micromolecular histidine derivative, has attracted increasing attention from scholars since it was confirmed in the human body. In the human body, ergothioneine is transported and accumulated specifically through OCTN−1, especially in the mitochondria and nucleus, suggesting that it can target damaged cells and tissues as an antioxidant. It shows excellent antioxidant, anti-inflammatory effects, and anti-aging properties, and inhibits melanin production. It is a mega antioxidant that may participate in the antioxidant network system and promote the reducing glutathione regeneration cycle. This review summarizes studies on the antioxidant effects of ergothioneine on various free radicals in vitro to date and systematically introduces its biological activities and potential mechanisms, mostly in dermatology. Additionally, the application of ergothioneine in cosmetics is briefly summarized. Lastly, we propose some problems that require solutions to understand the mechanism of action of ergothioneine. We believe that ergothioneine has good prospects in the food and cosmetics industries, and can thus meet some needs of the health and beauty industry.

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“…The regression equation of 12 phytohormones were obtained by plotting the detected peak areas of their corresponding concentrations (Supplementary Table 1). Meanwhile, the 100 mg of similar samples were also collected to, respectively, investigate the concentration of total sugar, soluble sugar, trehalose, and sucrose content using Sugar Content Assay Kit (Solarbio, Beijing, China) as described by Pan et al (2022). Three biological replicates of each sample were performed to estimate these plants physiological index.…”

Section: Extraction and Detection Of Phytohormones And Sugar Substancesmentioning

confidence: 99%

Integrated transcriptome and plant growth substance profiles to identify the regulatory factors involved in floral sex differentiation in Zanthoxylum armatum DC

Hui

Fan²,

Liu³

et al. 2022

Front. Plant Sci.

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Zanthoxylum armatum is a prominent plant for food industries. Its male flowers often occur in gynogenesis plants; however, the potential mechanism remains poorly understood. Herein, a total of 26 floral sex differentiation stages were observed to select four vital phases to reveal key factors by using RNA-seq, phytohormones and carbohydrates investigation. The results showed that a selective abortion of stamen or pistil primordia could result in the floral sex differentiation in Z. armatum. Carbohydrates might collaborate with cytokinin to effect the male floral differentiation, whereas female floral differentiation was involved in SA, GA1, and ABA biosynthesis and signal transduction pathways. Meanwhile, these endogenous regulators associated with reproductive growth might be integrated into ABCDE model to regulate the floral organ differentiation in Z. armatum. Furthermore, the 21 crucial candidates were identified in co-expression network, which would contribute to uncovering their roles in floral sex differentiation of Z. armatum in further studies. To the best of our knowledge, this study was the first comprehensive investigation to link floral sex differentiation with multi-level endogenous regulatory factors in Z. armatum. It also provided new insights to explore the regulatory mechanism of floral sex differentiation, which would be benefited to cultivate high-yield varieties in Z. armatum.

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Ergothioneine exhibits longevity-extension effect in Drosophila melanogaster via regulation of cholinergic neurotransmission, tyrosine metabolism, and fatty acid oxidation

Abstract: Many studies have demonstrated the protective effect of ergothioneine (EGT), the unique sulfur-containing antioxidant in mushrooms, on several aging-related diseases. Nevertheless, to date, no single study has explored the potential...

Cited by 13 publications

References 53 publications

Anti-Aging and Neuroprotective Properties of Grifola frondosa and Hericium erinaceus Extracts

Anti-Aging and Neuroprotective Properties of Grifola frondosa and Hericium erinaceus Extracts

Safe and Effective Antioxidant: The Biological Mechanism and Potential Pathways of Ergothioneine in the Skin

Integrated transcriptome and plant growth substance profiles to identify the regulatory factors involved in floral sex differentiation in Zanthoxylum armatum DC

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