Ergostane-Type Sterols From Several  <i>Cordyceps</i> Strains

Yoneyama, Tatsuro; Takahashi, Hiroki; Grudniewska, Aleksandra; Ban, Sayaka; Umeyama, Akemi; Noji, Masaaki

doi:10.1177/1934578x221105363

Cited by 2 publications

(2 citation statements)

References 39 publications

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“…Similar to those of compounds (1) and (2) , the spectral data of (3) were indicative of an ergostane structure, which entirely shared identities to the published literature by [ 26 ]. Thus, the structure of (3β,5α,22E)-ergosta-6,8(14),22-triene- 3,5-diol was proposed for compound (3) ( Figure 2 ).…”

Section: Resultssupporting

confidence: 77%

Steroid Components of Marine-Derived Fungal Strain Penicillium levitum N33.2 and Their Biological Activities

Hoang,

Le,

Nguyen

et al. 2023

Mycobiology

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Genus Penicillium comprising the most important and extensively studied fungi has been well-known as a rich source of secondary metabolites. Our study aimed to analyze and investigate biological activities, including in vitro anti-cancer, anti-inflammatory and anti-diabetic properties, of metabolites from a marine-derived fungus belonging to P. levitum . The chemical compounds in the culture broth of P. levitum strain N33.2 were extracted with ethyl acetate. Followingly, chemical analysis of the extract leaded to the isolation of three ergostane-type steroid components, namely cerevisterol (1) , ergosterol peroxide (2) , and (3β,5α,22E)-ergosta-6,8(14),22-triene-3,5-diol (3) . Among these, (3) was the most potent cytotoxic against human cancer cell lines Hep-G2, A549 and MCF-7 with IC 50 values of 2.89, 18.51, and 16.47 µg/mL, respectively, while the compound (1) showed no significant effect against tested cancer cells. Anti-inflammatory properties of purified compounds were evaluated based on NO-production in LPS-induced murine RAW264.7 macrophages. As a result, tested compounds performed diverse inhibitory effects on NO production by the macrophages, with the most significant inhibition rate of 81.37 ± 1.35% at 25 µg/mL by the compound (2) . Interestingly, compounds (2) and (3) exhibited inhibitory activities against pancreatic lipase and α-glucosidase enzymes in vitro assays. Our study brought out new data concerning the chemical properties and biological activities of isolated steroids from a P. levitum fungus.

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Section: Resultssupporting

confidence: 77%

Steroid Components of Marine-Derived Fungal Strain Penicillium levitum N33.2 and Their Biological Activities

Hoang,

Le,

Nguyen

et al. 2023

Mycobiology

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“…Ergosta-7, 9 (11), 22-Trien-3β-ol (EK100) EK100 (C 28 H 44 O; MW 396.64 g/mol) is a derivative of fungal ergosterol. Ergosterols are the active components of Cordyceps and have important therapeutic activities, such as analgesic, antimicrobial, antitumor, antioxidant, anti-inflammatory, antidiabetic, antihyperlipidemic, and immunomodulatory activities [129,[198][199][200][201][202][203].…”

Section: Polysaccharidesmentioning

confidence: 99%

Unique Bioactives from Zombie Fungus (Cordyceps) as Promising Multitargeted Neuroprotective Agents

Sharma,

2023

Nutrients

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Cordyceps, also known as “zombie fungus”, is a non-poisonous mushroom that parasitizes insects for growth and development by manipulating the host system in a way that makes the victim behave like a “zombie”. These species produce promising bioactive metabolites, like adenosine, β-glucans, cordycepin, and ergosterol. Cordyceps has been used in traditional medicine due to its immense health benefits, as it boosts stamina, appetite, immunity, longevity, libido, memory, and sleep. Neuronal loss is the typical feature of neurodegenerative diseases (NDs) (Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS)) and neurotrauma. Both these conditions share common pathophysiological features, like oxidative stress, neuroinflammation, and glutamatergic excitotoxicity. Cordyceps bioactives (adenosine, N6-(2-hydroxyethyl)-adenosine, ergosta-7, 9 (11), 22-trien-3β-ol, active peptides, and polysaccharides) exert potential antioxidant, anti-inflammatory, and anti-apoptotic activities and display beneficial effects in the management and/or treatment of neurodegenerative disorders in vitro and in vivo. Although a considerable list of compounds is available from Cordyceps, only a few have been evaluated for their neuroprotective potential and still lack information for clinical trials. In this review, the neuroprotective mechanisms and safety profile of Cordyceps extracts/bioactives have been discussed, which might be helpful in the identification of novel potential therapeutic entities in the future.

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Ergostane-Type Sterols From Several Cordyceps Strains

Cited by 2 publications

References 39 publications

Steroid Components of Marine-Derived Fungal Strain Penicillium levitum N33.2 and Their Biological Activities

Steroid Components of Marine-Derived Fungal Strain Penicillium levitum N33.2 and Their Biological Activities

Unique Bioactives from Zombie Fungus (Cordyceps) as Promising Multitargeted Neuroprotective Agents

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