Ergonomic handheld OCT angiography probe optimized for pediatric and supine imaging

Viehland, Christian; Chen, Xi; Tran-Viet, Du; Jackson-Atogi, Moseph; Ortiz, Pablo; Waterman, Gar; Vajzovic, Lejla; Toth, Cynthia A.; Izatt, Joseph A.

doi:10.1364/boe.10.002623

Cited by 66 publications

(56 citation statements)

References 60 publications

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“…Optical coherence tomography angiography (OCTA) can be used to elaborate these changes with additional information about smaller vessels and the position of vessels within the retinal structure, making it a valuable tool to study retinal microvasculature abnormalities that may be present in aniridia. Portable 5 , 6 OCTA systems used during examination under anesthesia have proven to be reliable in capturing images in children with retinal disease, especially infants and those with nystagmus, making portable OCTA devices particularly helpful for aniridia cases. Here we present a unique OCTA observation in an aniridic patient and a clinico-histopathologic correlation.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathologic correlation of aniridia: Optical coherence tomography angiography and histopathologic observations

Therattil

Naranjo

Hsu

et al. 2020

American Journal of Ophthalmology Case Reports

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Purpose To describe optical coherence tomography angiography (OCTA) findings in a patient with aniridia and correlate with representative histopathology. Observations OCTA images of the macula of a pediatric aniridic patient, who has nystagmus and impaired vision bilaterally, demonstrate a complete absence of the foveal avascular zone (FAZ) in both the superficial and deep vascular complexes (SVC and DVC). In addition, larger superficial blood vessels were found to be abnormally diving from the SVC into the DVC. Similarly, immunofluorescence with confocal microscopy imaging of a retinal histopathology specimen from a 2 month old aniridic patient demonstrated larger vessels diving in the same manner. Conclusions and importance This study highlights the clinical, imaging and histopathologic findings of aniridia. Supine OCTA imaging, performed during examination under anesthesia, allowed for visualization of retinal microvasculature in eyes with nystagmus. The histopathology images helped validate OCTA findings that, with further investigation, may lead to new information about the development of abnormal retinal microvasculature.

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Section: Introductionmentioning

confidence: 99%

Clinicopathologic correlation of aniridia: Optical coherence tomography angiography and histopathologic observations

Therattil

Naranjo

Hsu

et al. 2020

American Journal of Ophthalmology Case Reports

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“…We performed bedside SS-OCT imaging with an investigational system featuring a 200 kHz, 1060 nm SS laser (Axsun Technologies Inc., Billerica, MA) and a 700 g handheld, noncontact probe. 38 We captured anisotropic 10 x 10 mm OCT volumes with 950 A-scans per B-scan and 256 B-scans per volume. Two B-scans were acquired at each lateral location on the slow axis to allow for averaging in post-processing.…”

Section: Methodsmentioning

confidence: 99%

Auto-Processed Retinal Vessel Shadow View Images From Bedside Optical Coherence Tomography to Evaluate Plus Disease in Retinopathy of Prematurity

Seely

Wang

Tai

et al. 2020

Trans. Vis. Sci. Tech.

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To describe the creation of en face retinal vessel shadow view (RVSV) optical coherence tomography (OCT) images and assess the feasibility of using these for evaluating vascular disease in preterm infants at risk for retinopathy of prematurity (ROP). Methods: In this exploratory study, we selected images from eyes with a range of ROP vascular disease, prospectively acquired from preterm infants using an investigational, noncontact, handheld, bedside swept-source OCT. We autosegmented OCT volumes using custom infant-specific software, extracted RVSV-OCT images from volumetric data bracketed around the retinal pigment epithelium, and automontaged the resulting RVSV-OCT images. Three masked ophthalmologists graded the RVSV-OCT montages as plus, pre-plus, or neither and ranked them by relative vascular disease severity. Results: We selected images from 17 imaging sessions (7 plus, 4 pre-plus, 6 neither on clinical examination). On review, 15/17 (88%) RVSV-OCT montages were gradable for plus, pre-plus, or neither and all 17 montages were rankable for relative severity. Intergrader agreement for plus, pre-plus, or neither grading was good (κ, 0.67; 95% confidence interval, 0.42-0.86) and for relative severity ranking was excellent (intraclass correlation coefficient, 0.98; 95% confidence interval, 0.96-0.99). Conclusions: Our novel automatic processing method can create RVSV-OCT montages optimized for retinal vessel visualization for ROP screening. Although our data support the feasibility of using RVSV-OCT montages for ranking relative vascular disease severity, there is room for improved OCT image capture and processing methods in preterm infants screened for ROP. Translational Relevance: Creation and grading of RVSV-OCT images could eventually be integrated into an alternative method for ROP screening.

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“…Groups have recently described handheld OCT probes and demonstrated OCTA imaging in awake and sedated infants. 41,42 However, we believe the integrated motion tracking and realtime retinal aiming capabilities of SECTR provide significant advantages for point-of-care ophthalmic diagnostic imaging over these previous technologies. Here, we demonstrated an efficient motion-correction method in single OCT volumes and proof-of-concept multivolumetric mosaicking of OCTA projections.…”

Section: Advantages Of Spectrally Encoded Coherence Tomography and Rementioning

confidence: 99%

“…[38][39][40] However, these studies were performed using OCT systems that had limited aiming and retinal-tracking functionality. Similarly, while groups recently published handheld OCT probes optimized for pediatric imaging, 41,42 these devices lack integrated motion tracking, widefield imaging, and real-time retinal-aiming capabilities that are necessary to overcome current limitations in point-of-care ophthalmic diagnostic imaging. We believe that our handheld SECTR imaging probe will improve image quality, enable robust structural and functional imaging, and benefit clinical ergonomics for imaging bedridden and pediatric patients.…”

Section: Introductionmentioning

confidence: 99%

Handheld spectrally encoded coherence tomography and reflectometry for motion-corrected ophthalmic optical coherence tomography and optical coherence tomography angiography

et al. 2019

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Optical coherence tomography (OCT) is the gold standard for quantitative ophthalmic imaging. The majority of commercial and research systems require patients to fixate and be imaged in a seated upright position, which limits the ability to perform ophthalmic imaging in bedridden or pediatric patients. Handheld OCT devices overcome this limitation, but image quality often suffers due to a lack of real-time aiming and patient eye and photographer motion. We describe a handheld spectrally encoded coherence tomography and reflectometry (SECTR) system that enables simultaneous en face reflectance and cross-sectional OCT imaging. The handheld probe utilizes a custom double-pass scan lens for fully telecentric OCT scanning with a compact optomechanical design and a rapid-prototyped enclosure to reduce the overall system size and weight. We also introduce a variable velocity scan waveform that allows for simultaneous acquisition of densely sampled OCT angiography (OCTA) volumes and widefield reflectance images, which enables highresolution vascular imaging with precision motion-tracking for volumetric motion correction and multivolumetric mosaicking. Finally, we demonstrate in vivo human retinal OCT and OCT angiography (OCTA) imaging using handheld SECTR on a healthy volunteer. Clinical translation of handheld SECTR will allow for high-speed, motion-corrected widefield OCT and OCTA imaging in bedridden and pediatric patients who may benefit ophthalmic disease diagnosis and monitoring.

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Ergonomic handheld OCT angiography probe optimized for pediatric and supine imaging

Cited by 66 publications

References 60 publications

Clinicopathologic correlation of aniridia: Optical coherence tomography angiography and histopathologic observations

Clinicopathologic correlation of aniridia: Optical coherence tomography angiography and histopathologic observations

Auto-Processed Retinal Vessel Shadow View Images From Bedside Optical Coherence Tomography to Evaluate Plus Disease in Retinopathy of Prematurity

Handheld spectrally encoded coherence tomography and reflectometry for motion-corrected ophthalmic optical coherence tomography and optical coherence tomography angiography

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