We prove the Farrell-Jones Conjecture for mapping class groups. The proof uses the Masur-Minsky theory of the large scale geometry of mapping class groups and the geometry of the thick part of Teichmüller space. The proof is presented in an axiomatic setup, extending the projection axioms in [14]. More specifically, we prove that the action of Mod(Σ) on the Thurston compactification of Teichmüller space is finitely F -amenable for the family F consisting of virtual point stabilizers.