Ergebnisse serologischer Untersuchungen bei der multiplen Sklerose

Thirty-eight Cases of the Guillain-Barre Syndrome: An Immunological Study

“…Nearly all searches for circulating complement-fixing antibodies to nervous tissue have been made in sera from cases of disseminated sclerosis; positive results in some cases have been claimed by Sachs and Steiner (1934), Roemer et al (1953), Frick (1954, Delank (1957), andRaskin (1955), though these results were obtained only by using alcoholic extracts of formalinfixed brains from cases of disseminated sclerosis as antigens. Detailed investigation of comprehensive control groups of normal subjects or other diseases were not reported by these authors, nor were any attempts made to assess the organ-specificity of the reaction.…”

Failure to Demonstrate Circulating Antibody to Alcoholic Brain Extracts in Multiple Sclerosis

“…However, he goes on to point out, as did Sachs and Steiner (1934), that many florid and progressive cases are seen which nevertheless show no antibodies on repeated examination. Roemer et al (1953) found that three out of six cases of amyotrophic lateral sclerosis showed antibodies to brain. These authors reported circulating antibody in about 50% of clinically certain multiple-sclerosis patients, in 3.1% of other neurological conditions, and in almost 10% of a control group of various " internal diseases.…”

“…The reported occurrence of antibodies to brain in amyotrophic lateral sclerosis (Roemer et al, 1953) and after insulin convulsion therapy (Read et al, 1939) suggests that, if genuine, it may be secondary to destruction of myelin. However, we were unable to find any such antibodies in six patients at intervals from three weeks to three months after serious brain injury.…”