“…In many cases, TCCs show local recurrences; while, in a few cases, they develop into inva sive carcinoma [3]. Therefore, bladder cancer includes a large range of tumors from superficial, characterized by slower proliferation, to infiltrating and aggressive tu mors [4], ogy of neoplastic diseases. In particular, the cellular het erogeneity in terms of the ploidy level, the occurrence of multiclonality and proliferative patterns have been ana lyzed and were found to correlate with morphological parameters and clinical course [5][6][7].…”