Erfolgreiche Therapie mit Tetracyclin und Nikotinaminsäure beim vernarbenden Pemphigoid

Abstract

We describe a case of cicatricial pemphigoid in a 92-year-old female with extensive mucocutaneous involvement. She developed extensive hemorrhagic blistering with severely bleeding lesions, that healed with scarring. The conjunctivae showed extensive synechia. The diagnosis was based on clinical and histopathological features as well as immunofluorescence findings and immunoblot analysis. There was no clinical response to topical corticosteroids. The patient was given tetracycline and nicotinamid and showed rapid improvement of the mucocutaneous lesions within a few weeks. The clinical features, differential diagnosis and various treatment modalities of cicatricial pemphigoid are briefly reviewed, whereby the use of tetracycline and nicotinamide is discussed as an alternative effective and safe therapy for this potentially incapacitating condition.

Desquamative gingivitis as a sole presentation in mucous membrane pemphigoid: A rare case report with a brief review of literature

“…[33][34][35] However,dapsone usage should be regularly followed with periodic blood studies because of the associated complication of hemolytic anemia. Other systemic medications, including immunosuppressive agents such as azathioprine, methotrexate, cyclophosphamide, levamisole, and mycophenolate mofetil may also prove beneficial in the treatment of pemphigoid, [36][37][38][39][40][41][42] Studies have shown that MMP can be treated efficiently with tetracycline derivatives or combination therapy of tetracycline and niacinamide. [39][40][41] Alternately, intravenous immunoglobulins, plasmapheresis, and Low-level laser therapy (LLLT) can also be used as a therapeutic modality.…”