Eremophilenolides from Hertia cheirifolia

Aclinou, P.; Benkouider, Abdelhamid; Massiot, Georges; Men‐Olivier, L. Le

doi:10.1016/0031-9422(91)85074-a

Cited by 21 publications

(24 citation statements)

References 11 publications

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“…Eight known compounds 2-9 were the results after repeated column chromatography of the methanol extract of the root of Cacalia tangutica and were deduced by spectral data as petasine (2), 19 two triterpenes, α-amyrin (3) 20 and ursolic acid (4), 20 one isopentenyl acetophnon derivative, hydroxytremetone (5), 21 three cumarins, daphnetol (6), 22 hydrangetin (7), 22 umbelliferone (8), 23 one steroid, β-sitosterol (9).…”

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confidence: 99%

“…[4][5][6][7][8][9] Recently, we have investigated the chemical constituents of Cacalia tangutica (Senecioneae). From a methanol extract of the root, one new eremophilane sesquiterpene, 12-hydroxy-3α-angeloyloxy-eremophila-6,9-dien-8-one (1) combined with eight known compounds: one sesquiterpene, petasine (2), two triterpenes, α-amyrin (3) and ursolic acid (4), one isopentenyl acetophnon derivative, hydroxytremetone (5), three cumarins, daphnetol (7,8-dihydroxycumarin) (6), hydrangetin (7), umbelliferone (8), one steroid, β-sitosterol (9) were isolated.…”

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confidence: 99%

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The Components of Cacalia tangutica

Liu¹,

Tian²

2004

Bulletin of the Korean Chemical Society

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confidence: 99%

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The Components of Cacalia tangutica

Liu¹,

Tian²

2004

Bulletin of the Korean Chemical Society

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“…The known compounds 3 – 9 were identified as furanoeremophilan-10β-ol ( 3 ) (Jennings et al, 1976); 3β-angeloyloxyeremophila-7,11-dien-14β,6α-olide ( 4 ) (Li et al, 2004); furanoeremophil-3- en -14,6α-olide ( 5 ) (Kuroda et al, 1982); 10β-dihydroxyeremophilenolide ( 6 ) (Aclinqu et al, 1991); 8β,10β-dihydroxyeremophilenolide ( 7 ) (Kojima et al, 1997); 11-hydroxyvalenc-1(10)- en -2-one ( 8 ) (Savona et al, 1987); and ( 3R , 4R , 6S )-3,6-dihydroxy-1-menthene ( 9 ) (Cuenca et al, 1991), respectively, on the basis that their HRESI-MS and NMR data were consistent with the literature.…”

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confidence: 99%

Phytotoxic Terpenoids from Ligularia cymbulifera Roots

et al. 2017

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Ligularia cymbulifera is one of the predominant species in the Hengduan Mountains, China, and has led to a decrease in the amount of forage grass in this area. However, little is known about the mechanism behind its predominance. In this study, two novel eremophilane sesquiterpenes, ligulacymirin A and B (1 and 2), together with seven other known terpenoids (3–9), were isolated from the roots of L. cymbulifera. The structures of 1 and 2 were determined by spectroscopic methods and single-crystal X-ray diffraction. Each compound showed phytotoxic activities against Arabidopsis thaliana, and each was detected and identified in rhizosphere soil by UHPLC-MS. Compound 3 was the most potent phytotoxin, showing remarkable inhibition against both seedling growth (EC50 = 30.33 ± 0.94 μg/mL) and seed germination (EC50 = 155.13 ± 0.52 μg/mL), with an average content in rhizosphere soil of 3.44 μg/g. These results indicate that terpenoids in L. cymbulifera roots might be released as phytotoxins in rhizosphere soil to interfere with neighboring plants.

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“…It is originally from Algeria and Tunisia (Le Hou erou 1995) and used by traditional healers for the treatment of spasm, inflammation, diarrhea and haemorrhoid (Iserin 2001). Phytochemical analysis showed the presence of sesquiterpenoids and steroids (Aclinou et al 1991;Ammar et al 2009). However, few studies on biological activities of H. cheirifolia have been reported.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical screening and anti-inflammatory properties of AlgerianHertia cheirifoliamethanol extract

Bouriche

Kada

Assaf

et al. 2016

Pharmaceutical Biology

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Context: Hertia cheirifolia L. (Asteraceae) is traditionally used in Northern Africa to treat various inflammatory infections. However, few studies on this plant have been reported. Objective: The anti-inflammatory activity of methanol extract of H. cheirifolia leaves was investigated using different experimental models. Materials and methods: Phytochemical analysis was performed to determine phenolic compounds. Acute toxicity of the extract (2000 mg/kg) was examined in Swiss albino mice for 14 days, before croton oilinduced ear oedema in mice, carrageenan-induced paw oedema in Swiss albino rats, cotton pellet-induced granuloma in rats and carrageenan-induced air pouch in mice were conducted. The IL-1b and TNF-a release from concanavalin A-stimulated monocytes was measured by ELISA. Results: Methanol extract of H. cheirifolia is rich in polyphenols and flavonoids. Cinnamic acid and rutin represent the major constituents. Methanol extract up to 2000 mg/kg did not produce any toxic effects. Topical application of 2 mg/ear of the extract produced 78.7% of inhibition on ear swilling. Oral pre-treatment of rats with 200 and 400 mg/kg of the extract inhibited paw oedema by 70% and 89%, respectively. At 200 mg/kg, granuloma dry and wet weights were reduced by 41.85% and 61.72%, respectively. Moreover, the treatment with methanol extract at 1 mg/kg exerted 62.7% of inhibition on leucocytes migrated into the ear pouch. TNF-a and IL-1b release was reduced by 69% and 78%, respectively, with 1 lg/mL of the extract. Conclusion: Methanol extract of H. cheirifolia possesses a strong anti-inflammatory activity and may be considered an interesting source of effective anti-inflammatory compounds.ARTICLE HISTORY

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Eremophilenolides from Hertia cheirifolia

Cited by 21 publications

References 11 publications

The Components of Cacalia tangutica

The Components of Cacalia tangutica

Phytotoxic Terpenoids from Ligularia cymbulifera Roots

Phytochemical screening and anti-inflammatory properties of AlgerianHertia cheirifoliamethanol extract

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