Erectile function in male rats after lesions in the lateral paragigantocellular nucleus

Liu, Yian-Cheng; Sachs, Benjamin D.

doi:10.1016/s0304-3940(99)00070-1

Cited by 22 publications

(13 citation statements)

References 14 publications

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“…Thus, these results provide additional anatomical verification of the physiological and behavioral studies that have described an inhibitory influence of this brainstem area over voiding and sexual reflexes (Marson and McKenna, 1990;Yells et al, 1992;Liu and Sachs, 1999).…”

Section: Gi-lpgi Projections To Motoneuronssupporting

confidence: 73%

“…To briefly summarize, behavioral studies support the hypothesis that this ventral medullary reticular area exerts descending inhibitory control of sexual reflexes (Marson and McKenna, 1990;Yells et al, 1992;Liu and Sachs, 1999). Electrical stimulation of the dorsal nerve of the penis or the pudendal nerve elicits responses within this medullary reticular area (Hubscher and Johnson, 1996).…”

Section: Introductionmentioning

confidence: 82%

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Descending spinal projections from the rostral gigantocellular reticular nuclei complex

Hermann

Holmes

Rogers

et al. 2002

J of Comparative Neurology

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Electrophysiological and physiological studies have suggested that the ventral medullary gigantocellular reticular nuclei (composed of the gigantocellular ventralis and pars alpha nuclei as well as the adjacent lateral paragigantocellular nucleus; abbreviated Gi-LPGi complex) provide descending control of pelvic floor organs (Mackel [1979] J. Physiol. (Lond.) 294:105-122; Hubscher and Johnson [1996] J. Neurophysiol. 76:2474-2482; Hubscher and Johnson [1999] J. Neurophysiol. 82:1381-1389; Johnson and Hubscher [1998] Neuroreport 9:341-345). Specifically, this complex of paramedian reticular nuclei has been implicated in the inhibition of sexual reflexes. In the present study, an anterograde fluorescent tracer was used to investigate direct descending projections from the Gi-LPGi complex to retrogradely labeled pudendal motoneurons (MN) in the male rat. Our results demonstrated that, although a high density of arborizations from Gi-LPGi fibers appears to be in close apposition to pudendal MNs, this relationship also applies to other MNs throughout the entire spinal cord. The Gi-LPGi also projects to spinal autonomic regions, i.e., both the intermediolateral cell column and the sacral parasympathetic nucleus, as well as to regions of the intermediate gray, which contain interneurons involved in the organization of pelvic floor reflexes. Lastly, throughout the length of the spinal cord, numerous neurons located primarily in laminae VII-X, were retrogradely labeled with Fluoro-Ruby after injections into the Gi-LPGi. The diffuse descending projections and arborizations of this pathway throughout the spinal cord suggest that this brainstem area is involved in the direct, descending control of a variety of spinal activities. These results are in contrast with our observations of the discrete projections of the caudal nucleus raphe obscurus, which target the autonomic and somatic MNs involved specifically in sexual and eliminative functions (Hermann et al. [1998] J. Comp. Neurol. 397:458-474).

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Section: Gi-lpgi Projections To Motoneuronssupporting

confidence: 73%

Section: Introductionmentioning

confidence: 82%

Descending spinal projections from the rostral gigantocellular reticular nuclei complex

Hermann

Holmes

Rogers

et al. 2002

J of Comparative Neurology

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“…26 However, an improvement in sexual performance may result from rigid and sustained erection which promotes greater tactile stimulation of the penis due to increased contact with the vagina. 27 Interestingly, similar overall effects on sexual competence in male rats have been previously reported with herbal drugs. 28 In conclusion, this study demonstrates, for the first time, that the NO donor, SNP, impairs sexual competence but not fertility of male rats.…”

Section: Discussionsupporting

confidence: 72%

Sodium nitroprusside impairs sexual competence of male rats

Ratnasooriya

Jayakody²,

Dharmasiri

2004

Hum Exp Toxicol

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Recently, sodium nitroprusside (SNP), a potent nitric oxide (NO) donor and a clinically used antihypertensive, has been introduced as a penile self-injection medical therapy for erectile dysfunction. However, it is known that many antihypertensives impairs sexual competence; NO regulates sexual competence and NO is cytostatic and cytotoxic for human sperm. Thus, a possibility exists that SNP may impair male reproductive competence. Testing this aspect is the aim of this study. This was assessed in male rats (using three I.P. doses: 60, 30 or 20 g/kg) using noncompetitive copulation tests. The results show that the highest dose of SNP was toxic and caused rapid mortality of treated rats (within 30 min). The mid and low doses of SNP reversibly impaired several parameters of sexual competence in a dose-related fashion: sexual arousability, libido and sexual vigour. Some parameters of sexual behaviour remained unaltered: sexual motivation and intromission ratio, whilst one parameter was improved: sexual performance. In complete contrast, the ejaculatory competence and fertility remained unchanged. The SNP-induced impairments in sexual competence may be attributable to lowered testosterone levels and sedation mediated via its specific action and/or side effect. Further, this impairment of sexual function was not due to general toxicity, inhibition of penile sensitivity, penile erection or analgesic activity. It is concluded that SNP impairs male sexual competence, at least, in rats although it promotes penile erection.

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“…NO is capable of stimulating dopamine (DA) release in the mPOA, which in turn stimulates penile erection. This mechanism may constitute one way in which androgens stimulate sexual arousal [35]. …”

Section: Androgen-based Mechanism Of Sexual Behaviormentioning

confidence: 99%

A Review on Plants Used for Improvement of Sexual Performance and Virility

Chauhan

Sharma

Dixit

et al. 2014

BioMed Research International

144

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The use of plant or plant-based products to stimulate sexual desire and to enhance performance and enjoyment is almost as old as the human race itself. The present paper reviews the active, natural principles, and crude extracts of plants, which have been useful in sexual disorders, have potential for improving sexual behaviour and performance, and are helpful in spermatogenesis and reproduction. Review of refereed journals and scientific literature available in electronic databases and traditional literature available in India was extensively performed. The work reviews correlation of the evidence with traditional claims, elucidation, and evaluation of a plausible concept governing the usage of plants as aphrodisiac in total. Phytoconstituents with known structures have been classified in appropriate chemical groups and the active crude extracts have been tabulated. Data on their pharmacological activity, mechanism of action, and toxicity are reported. The present review provides an overview of the herbs and their active molecule with claims for improvement of sexual behaviour. A number of herbal drugs have been validated for their effect on sexual behavior and fertility and can therefore serve as basis for the identification of new chemical leads useful in sexual and erectile dysfunction.

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Erectile function in male rats after lesions in the lateral paragigantocellular nucleus

Cited by 22 publications

References 14 publications

Descending spinal projections from the rostral gigantocellular reticular nuclei complex

Descending spinal projections from the rostral gigantocellular reticular nuclei complex

Sodium nitroprusside impairs sexual competence of male rats

A Review on Plants Used for Improvement of Sexual Performance and Virility

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