Erectile function after treatment for rhabdomyosarcoma of prostate and bladder

Frees, Sebastian; Rubenwolf, Peter; Ziesel, C.; Faber, Jörg; Gutjahr, P.; Großmann, Allegra; Thüroff, J.W.; Stein, Raimund

doi:10.1016/j.jpurol.2016.07.002

Cited by 13 publications

(12 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is the only study on adults with questionnaires but also deals with low number of patients who were treated with surgery and radio-/brachytherapy ( (Lobo et al 2022), are restricted by their ambiguous de nition of normal bladder function (Arndt et al 2004) and do not always describe surgical details since the primary focus is still on the oncological outcome. Current research also suggests, that problems of the lower urinary tract and/or ED may increase with a longer median follow-up (Frees et al 2016; Castagnetti, Herbst, and Esposito 2019). Our study included 40 patients with BPS, 32 of whom received additional BT.…”

Section: Resultsmentioning

confidence: 99%

Detailed functional results after bladder-preserving surgery and high-dose-rate brachytherapy in pediatric bladder/prostate rhabdomyosarcoma

Ellerkamp

Schmidt

Warmann

et al. 2022

Preprint

View full text Add to dashboard Cite

Purpose: In pediatric bladder/prostate-rhabdomyosarcoma, the rate of bladder preservation after neoadjuvant chemotherapy is high, with an excellent oncological outcome. Information about functional urological long-term outcomes is rare.Methods: Data of all patients who had undergone bladder-preserving surgery with or without brachytherapy at our institution between 2009 and 2020 were analyzed retrospectively.Detailed urological function was assessed focusing on age-related continence, bladder capacity and urodynamic findings.Results: We identified 40 patients, median age at surgery of 27 months (range 9-191), and 32 patients additionally received postoperative high-dose-rate brachytherapy. The median follow-up was 32.5 months (range 6-125). The bladder capacity increased from median 66.7% (21.1-180) of expected bladder capacity related to age 3 months after surgery to 87.4% (58.1-181.8) 9 months after surgery. In the group of aged >6-year-old, continence was 94% (83% with brachytherapy, 100% without brachytherapy). Erectile function was normal in 92% (90 % with brachytherapy, 100% without brachytherapy). Bladder capacity was more than 65% expected bladder capacity related to age in 70% (60% with brachytherapy, 86% without brachytherapy). 65% of all patients need neither anticholinergic drugs nor low-dose antibiotics (63% with brachytherapy, 71% without brachytherapy).Conclusions: Bladder preservation with good functional outcome can be achieved in localized bladder/prostate-rhabdomyosarcoma. In selected cases, supportive brachytherapy additionally contributes to an improvement in the oncological outcome with calculable risks for bladder and erectile function. Careful urological aftercare should be a fixed priority after oncological follow-ups.

show abstract

Section: Resultsmentioning

confidence: 99%

Detailed functional results after bladder-preserving surgery and high-dose-rate brachytherapy in pediatric bladder/prostate rhabdomyosarcoma

Ellerkamp

Schmidt

Warmann

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…However, B&P RMS survivors commonly experience treatment side-effects, such as: urinary incontinence, recurrent UTIs, decreased renal function, infertility and secondary malignancies. [12][13][14] Therefore, the modern therapy of B&P RMS is aimed at preserving the bladder and sexual function. In most cases the upfront biopsy followed by aggressive CHT, radiotherapy and, if necessary, delayed surgery of the residual tumor mass is preferred to avoid cysto-prostatectomy.…”

Section: Discussionmentioning

confidence: 99%

Delayed diagnosis of pediatric bladder and prostate rhabdomyosarcoma – causes and consequences

et al. 2021

View full text Add to dashboard Cite

Introduction: Pediatric rhabdomyosarcoma (RMS) is a rare disease, affecting 4.5-6.0 per 1 000 000 children a year. Bladder and/or prostate (B&P) is the primary tumor site in approximately 10% of patients. Initial symptoms of B&P RMS in children may mimic more common, benign conditions such as urinary tract infections (UTIs), functional disorders, and congenital anomalies of the urinary tract. Aim: The study aims to emphasize the role of careful clinical examination and strict following the diagnostic guidelines in early detection of pediatric B&P RMS in primary care and emergency department settings. Case study: We present two male patients aged 2.5 and 3 years with embryonal B&P RMS initially manifesting as atypical and/or recurrent UTI. In both children, proper diagnoses were delayed due to careless physical examination and failure to adhere to the current guidelines for UTI management. Despite symptoms of an atypical and severe course of UTI, no imaging examinations had been performed for several weeks until dramatic deteriorations of patients’ general conditions occurred. Results and discussion: The prolonged diagnostic processes caused unnecessary suffering of both children and significant delay of oncological treatment in one. In the latter patient, bladder preservation was not possible, resulting in decreased quality of life. Conclusions: Due to its rarity, B&P RMS is infrequently included in the differential diagnosis in children with recurrent or atypical UTI. However, thorough physical examination and adherence to the guidelines of UTI management enable timely diagnosis of underlying malignancy. Early diagnosis of B&P RMS leads to a better prognosis, less intensive treatment, and improved quality of life of B&P RMS survivors.

show abstract

“…Studies in which male survivors of the surgical treatment of pelvic tumours were followed up showed that erectile function was remarkably affected in many cases. [15,16] CT scan is a most valuable tool in the evaluation of children with these tumours for diagnosis and follow up of treatment. [17] However, only a few of the patients in our series could afford the investigation either for diagnosis or for follow up.…”

Section: Discussionmentioning

confidence: 99%

Paediatric Pelvic Tumours; Presentation, Diagnosis and Challenges of Treatment in a Low Resource Setting

E¹,

Gracia²

2019

AJCPN

View full text Add to dashboard Cite

Background: Paediatric pelvic solid tumours present peculiar challenge in clinical diagnosis due to their inherently obscure anatomic location, and the varied, often vague symptoms. Difficult surgical access and presence of important surrounding pelvic structures make their surgical treatment particularly challenging. Aim: To report our experience with paediatric pelvic solid tumours and to highlight the presentation pattern and challenges of diagnosis and treatment in our setting. Subjects and Methods: This is a five year retrospective study of pelvic solid tumours in children seen in our centre between December 2013 and November 2018. Data retrieved were demographics, presenting symptoms and duration, previous treatments, findings on examination, laboratory investigations, treatment given in our centre, histology of tumours and duration of follow up, outcome. Analysis was done on Microsoft Excel spread sheet Windows 2007. Results: Twenty three cases comprising 7 males and 16 females were included in this study. The age range was 1 to 14 years with a median at 6.5 years. Ten(43.5%) of these cases were benign, and 13(56.5%) were malignant. The teratomas comprised 9 benign cystic mature teratomas and 6 malignant teratomas. There were 4 mortalities and one recurrence. Conclusion: The anatomic location and vague early symptoms of pelvic tumours make early diagnosis difficult in our setting. High morbidity and mortality is the direct consequence. In a resource poor setting as ours, scrupulous physical examination including digital rectal examination is key to early diagnosis.

show abstract

Erectile function after treatment for rhabdomyosarcoma of prostate and bladder

Cited by 13 publications

References 20 publications

Detailed functional results after bladder-preserving surgery and high-dose-rate brachytherapy in pediatric bladder/prostate rhabdomyosarcoma

Detailed functional results after bladder-preserving surgery and high-dose-rate brachytherapy in pediatric bladder/prostate rhabdomyosarcoma

Delayed diagnosis of pediatric bladder and prostate rhabdomyosarcoma – causes and consequences

Paediatric Pelvic Tumours; Presentation, Diagnosis and Challenges of Treatment in a Low Resource Setting

Contact Info

Product

Resources

About