Erectile Dysfunction Treatment Using Focused Linear Low-Intensity Extracorporeal Shockwaves: Single-Blind, Sham-Controlled, Randomized Clinical Trial

Šrámková, Taťána; Motil, Igor; Jarkovský, Jiří; Šrámková, Kateřina

doi:10.1159/000504788

Cited by 16 publications

(6 citation statements)

References 34 publications

(41 reference statements)

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“…The mean age in the current cohort was 60 years (range 38–77), which is in concordance with previous findings [22]. Following Li-ESWT, 56% of our patients reported improved erectile function, which is similar to the results of other studies showing treatment success in approximately 60% of cases [12, 13, 27, 28]. Men with vasculogenic ED are the patients best suited for Li-ESWT, as none of the patients without cardiovascular risk factors demonstrated a significant response to Li-ESWT.…”

Section: Discussion/conclusionsupporting

confidence: 92%

Analysis of the Impact of Clinical Factors on Low-Intensity Extracorporeal Shockwave Therapy for Erectile Dysfunction

Oginski¹,

Apel²,

Richterstetter³

et al. 2022

Urol Int

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Introduction: Predictive factors for the treatment success of low-intensity extracorporeal shockwave therapy (Li-ESWT) for erectile dysfunction (ED) are still under debate. Methods: Li-ESWT was performed in 50 patients suffering from ED by applying 3,000 shock waves once a week over a period of 6 weeks. Treatment success was defined as an increase in the International Index of Erectile Function 5 (IIEF-5) score by ≥5 points or an Erectile Hardness Score (EHS) of ≥3 points. IIEF-5 and EHS were measured at baseline and at 3 and 6 months of follow-up. Results: Treatment success according to either the IIEF-5 score or EHS at any time of follow-up was achieved in 28 patients (56%). Twenty-five patients (50%) experienced an improvement during the first 3 months, which lasted for 6 months in 8 cases (16%). Three patients reported improved erectile function only after 6 months. When stratifying the cohort with regard to potential influencing factors, a significantly improved IIEF-5 score could be achieved in men with cardiovascular risk factors (p = 0.026) and in men with antihypertensive medication (p = 0.009). Men without cardiovascular risk factors showed no therapeutic benefit from Li-ESWT. Discussion/Conclusion: Li-ESWT is a valid but often short-lived treatment option for ED, especially in men with cardiovascular risk factors or controlled hypertension. Future studies should assess the feasibility and safety of repeated applications of Li-ESWT.

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Section: Discussion/conclusionsupporting

confidence: 92%

Analysis of the Impact of Clinical Factors on Low-Intensity Extracorporeal Shockwave Therapy for Erectile Dysfunction

Oginski¹,

Apel²,

Richterstetter³

et al. 2022

Urol Int

View full text Add to dashboard Cite

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“…Of the remaining 39 articles, 23 articles were excluded because they are not RCT or lack of effective data. Finally, the remaining 16 articles were included in the study to evaluate the effectiveness of LI-ESWT in the treatment of ED ( Baccaglini et al, 2020 ; Fojecki et al, 2017 ; Kalyvianakis & Hatzichristou, 2017 ; Kim et al, 2020 ; Kitrey et al, 2016 ; Ladegaard et al, 2021 ; Olsen et al, 2015 ; Ortac et al, 2021 ; Shendy et al, 2021 ; Sramkova et al, 2020 ; Srini et al, 2015 ; Vardi et al, 2012 ; Vinay et al, 2021 ; Yamaçake et al, 2019 ; Yee et al, 2014 ; Zewin et al, 2018 ). The details of each study are presented in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

Systematic Review and Meta-Analysis of 16 Randomized Controlled Trials of Clinical Outcomes of Low-Intensity Extracorporeal Shock Wave Therapy in Treating Erectile Dysfunction

et al. 2022

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We conducted a meta-analysis to evaluate the efficacy of low-intensity extracorporeal shock wave therapy (LI-ESWT) in the treatment of erectile dysfunction (ED). From July 2011 to June 2021, we finally selected 16 randomized controlled trials (RCTs) including 1,064 participants to evaluate the efficacy of LI-ESWT in the treatment of ED from PubMed, EMBASE, and Cochrane databases. The data are analyzed by Review Manager Version 5.4. Fifteen articles mentioned International Index of Erectile Function (IIEF), in the follow-up of 1 month (mean difference [MD] = 3.18, 95% confidence interval [CI] = [1.38, 4.98], p = .0005), 3 months (MD = 3.01, 95% CI = [2.04, 3.98], p < .00001), and 6 months (MD = 3.20, 95% CI = [2.49, 3.92], p < .00001). After treatment, the improvement of IIEF in the LI-ESWT group was better than that in the control group. Besides, eight of the 16 trials provided data on the proportion of patients with baseline Erectile Hardness Score (EHS) ≤ 2 improved to EHS ≥ 3. The LI-ESWT group was also significantly better than the placebo group (odds ratio [OR] = 5.07, 95% CI = [1.78, 14.44], p = .002). The positive response rate of Questions 2 and 3 of the Sexual Encounter Profile (SEP) was not statistically significant (SEP2: OR = 1.27, 95% CI = [0.70, 2.30], p = .43; SEP3: OR = 4.24, 95% CI = [0.67, 26.83], p = .13). The results of this meta-analysis suggest that treatment plans with an energy density of 0.09 mJ/mm2 and pulses number of 1,500 to 2,000 are more beneficial to IIEF in ED patients. In addition, IIEF improvement was more pronounced in patients with moderate ED after extracorporeal shockwave therapy.

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“…This study focused on examining questionnaires at the patients’ first visit, and we paid particular attention to observing SEP questions 2 and 3. SEP is often used as an indicator to assess the curative effect on erectile dysfunction, 11 and recently, it has also been utilized in the outcome assessment section for evaluating the curative effect on phosphodiesterase type 5 inhibitor 12,13 and the low intensity extracorporeal shockwave machine 14 . SEP question 2, “Were you able to insert your penis into your partner’s vagina?” can be interpreted as successfully able to insert the penis into the vagina.…”

Section: Discussionmentioning

confidence: 99%

Erectile dysfunction in young patients and elderly patients by sexual encounter profile: A comparative study

et al. 2022

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Objective: Demand for erectile dysfunction treatments has increased not only in elderly patients but also in young patients. Reports indicate that frequent causes of erectile dysfunction in Japan are organic disorders in elderly patients and psychogenetic disorders in young patients. Methods: We defined patients under the age of 40 as young erectile dysfunction patients, and those over 65 as elderly erectile dysfunction patients. We divided these two groups and conducted a retrospective comparative study based on medical questionnaires. We selected 215 cases of patients under the age of 40, and 176 cases of patients over the age of 65, and created a group of young patients and a group of elderly patients. We implemented the erectile hardness score, Sexual Health Inventory for Men, and sexual encounter profile questions 2 and 3 as the patient's daily clinical journal. Results: The median age of young patients was 36 years, and that of elderly patients was 70 years. With respect to Sexual Health Inventory for Men, the average score was a significantly higher score in the young patients (9.26 vs 7.10, P < 0.001). Concerning erectile hardness score, young patients showed significantly higher scores in erectile hardness score (3.15 vs 2.06, P < 0.001). In terms of sexual encounter profile question 2, 50.9% of young patients responded "yes," but 24.3% of elderly patients responded, thus indicating a significantly higher score in young patients. In terms of sexual encounter profile question 3, 6.1% of young patients responded "yes," and 0.7% of elderly patients responded "yes," indicating a significantly higher in young patients. Conclusions: The results showed that many young patients with erectile dysfunction were able to perform insertion, but were unable to maintain erection.

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Erectile Dysfunction Treatment Using Focused Linear Low-Intensity Extracorporeal Shockwaves: Single-Blind, Sham-Controlled, Randomized Clinical Trial

Cited by 16 publications

References 34 publications

Analysis of the Impact of Clinical Factors on Low-Intensity Extracorporeal Shockwave Therapy for Erectile Dysfunction

Analysis of the Impact of Clinical Factors on Low-Intensity Extracorporeal Shockwave Therapy for Erectile Dysfunction

Systematic Review and Meta-Analysis of 16 Randomized Controlled Trials of Clinical Outcomes of Low-Intensity Extracorporeal Shock Wave Therapy in Treating Erectile Dysfunction

Erectile dysfunction in young patients and elderly patients by sexual encounter profile: A comparative study

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