Erectile dysfunction: prevalence, risk factors and involvement of antihypertensive drugs intervention

Salman, Muhammad; Shehzadi, Naureen; Khan, Muhammad Talha; Islam, Muhammad; Sohail, Anjum; Afzal, Omer; Mansoor, Sibghat; Qamar, Shaista; Peerzada, Sohaib; Khan, Amer Hayat; Hussain, Khalid

doi:10.4314/tjpr.v15i4.29

Cited by 3 publications

(19 citation statements)

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“…It is estimated that approximately 40% of men suffer from erectile dysfunction or impotence at least occasionally. 7 , 21 The older the patient, the higher the rate of erectile dysfunction. The estimated prevalence is 1–10% in younger men (<40 years), 2–9% in middle-aged men (40–50 years), 20–40% in older individuals (60–69 years), and 50–100% in older individuals (>70 years).…”

Section: Resultsmentioning

confidence: 99%

“…The estimated prevalence is 1–10% in younger men (<40 years), 2–9% in middle-aged men (40–50 years), 20–40% in older individuals (60–69 years), and 50–100% in older individuals (>70 years). 7 There are various causes of erectile dysfunction are various, including testosterone deficiency, antidepressant drugs, aging, changes in cavernous molecules, and diseases such as hypertension. Hypertension is strongly associated with erectile dysfunction since arteriolar smooth muscle cells of the cavernous bodies are related to blood flow.…”

Section: Resultsmentioning

confidence: 99%

“…Hypertension is strongly associated with erectile dysfunction since arteriolar smooth muscle cells of the cavernous bodies are related to blood flow. 7 , 21–23 …”

Section: Resultsmentioning

confidence: 99%

“… 24 Erectile dysfunction can cause severe psychological distress and humiliation among most men, making it a health problem that needs to be considered clinically. 7 , 21–23 …”

Section: Resultsmentioning

confidence: 99%

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Relationship Between Hypertension, Antihypertensive Drugs and Sexual Dysfunction in Men and Women: A Literature Review

Lou,

Chen,

Ali

et al. 2023

VHRM

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Sexual dysfunction pertains to any issue that hinders an individual from attaining sexual contentment. This health issue can have a significant impact on the quality of life and psychological health of affected individuals. Sexual dysfunction can generate stress, anxiety, depression, and low self-esteem, which can lead to a reduction in overall life satisfaction and the quality of interpersonal relationships. Sexual dysfunction can manifest as erectile dysfunction in men or lack of sexual desire in women. Although both sexes can experience sexual problems, there are some significant differences in the manifestation of sexual dysfunction between men and women. In men, sexual dysfunction is usually physical and associated with problems such as erectile dysfunction, while in women, sexual dysfunction is usually related to psychological factors. Additionally, there was an association between hypertension and sexual dysfunction in both the sexes. In men, hypertension can cause erection problems, whereas in women, it can cause vaginal dryness and a decrease in sexual desire. Furthermore, antihypertensive drugs can negatively impact sexual function, which can decrease adherence to drug treatment. However, nebivolol, an antihypertensive drug, has beneficial effects on erectile dysfunction in men. This is believed to be because nebivolol improves blood flow to the penis by producing nitric oxide, which can help improve erections.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Hypertension is strongly associated with erectile dysfunction since arteriolar smooth muscle cells of the cavernous bodies are related to blood flow. 7 , 21–23 …”

Section: Resultsmentioning

confidence: 99%

“… 24 Erectile dysfunction can cause severe psychological distress and humiliation among most men, making it a health problem that needs to be considered clinically. 7 , 21–23 …”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Relationship Between Hypertension, Antihypertensive Drugs and Sexual Dysfunction in Men and Women: A Literature Review

Lou,

Chen,

Ali

et al. 2023

VHRM

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show abstract

“…In this study being on antihypertensive drugs which is caused by having high blood pressure as well as higher systolic blood pressure were associated with erectile dysfunction. The etiology of erectile dysfunction in hypertensive males is reported to be multifactorial and may be caused by vascular disease, decreased heart capacity, medication and/or other factors such as heavy smoking, psychological issues, obesity and physical inactivity (Salman et al 2016). Erectile dysfunction has been associated with use of β-blockers, thiazide diuretics, metformin, antidepressants, statins, fibrates and the drugs used for neuropathic pain such as pregabalin, gabapentin and opiate analgesics (Hackett 2016).…”

Section: Discussionmentioning

confidence: 99%

Erectile Dysfunction among Diabetic Patients at Parirenyatwa Group of Hospitals in Zimbabwe

Machingura¹

2018

TIJPH

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Erectile dysfunction is a major problem amongst diabetes mellitus patients. However sexual problems are not usually discussed with doctors due to embarrassment and lack of understanding of the condition thus the patients suffer silently. The study sought to determinate the prevalence of erectile dysfunction and associated factors amongst male diabetes mellitus patients attending the outpatient clinic at Parirenyatwa group of hospitals. Adult male diabetic patients who consented to participate in the study had a questionnaire administered on them to collect demographic data and an International Index of Erectile Function (IIEF-5) Questionnaire administered on them by a male medical doctor. Anthropometric measurements were conducted and samples were collected for laboratory investigations. The prevalence of erectile dysfunction was 73.9%. Erectile dysfunction was associated with higher age (p = 0.009), higher systolic blood pressure (p = 0.009) and being on hypertensive drugs (p = 0.007). The proportion of diabetic patients with higher glycosylated haemoglobin was higher among patients with erectile dysfunction (p = 0.020). This study shows high prevalence of erectile dysfunction in diabetes mellitus patients attending Parirenyatwa outpatient clinic. Erectile dysfunction was associated with higher age, higher systolic blood pressure and being on antihypertensive drugs. This study shows the need of consistent screening of erectile dysfunction among diabetic patients for early detection, treatment and prevention. There is also need for a large national study to confirm this prevalence and the associated factors.

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Meta-analysis of the effect of losartan relative to other angiotensin receptor antagonists on serum uric acid level

Zhou,

Zhang,

Cheng

2023

Trop. J. Pharm Res

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Purpose: To systematically analyze the disparity in uric acid reduction between losartan and other angiotensin receptor antagonists.Methods: A computer-based search was conducted in databases including EMBASE, PubMed, Wanfang, CNKI, Ovid MEDLINE, and Web of Science to identify original literature comparing the impact of losartan with other angiotensin receptor antagonists on blood uric acid levels. Utilizing the Cochrane Collaboration bias risk tool, a quality assessment of the included randomized controlled studies was conducted.Results: A total of 12 publications were obtained, consisting of 6 randomized controlled studies and 6 cohort studies. Five of the twelve publications assessed the impact of losartan compared to valsartan on blood uric acid levels. The heterogeneity analysis yielded I2 = 98 % (p < 0.01), indicating substantial variability among the studies. Findings indicated that losartan was more effective than valsartan in reducing blood uric acid levels (SMD = -3.26, 95 % CI (-5.01 to 1.51), p < 0.05). Four publications investigated the impact of losartan versus telmisartan on blood uric acid levels. The results revealed that losartan had a greater effect in reducing blood uric acid levels compared to telmisartan (SMD = -1.77, 95 % CI (-3.411 to -0.13), p < 0.05).Conclusion: Among the angiotensin receptor antagonists used as antihypertensive drugs, losartan stands out for its significant ability to reduce uric acid levels. This finding provides a strong evidencebase for making clinical medication decisions.

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Erectile dysfunction: prevalence, risk factors and involvement of antihypertensive drugs intervention

Cited by 3 publications

References 74 publications

Relationship Between Hypertension, Antihypertensive Drugs and Sexual Dysfunction in Men and Women: A Literature Review

Relationship Between Hypertension, Antihypertensive Drugs and Sexual Dysfunction in Men and Women: A Literature Review

Erectile Dysfunction among Diabetic Patients at Parirenyatwa Group of Hospitals in Zimbabwe

Meta-analysis of the effect of losartan relative to other angiotensin receptor antagonists on serum uric acid level

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