Erectile dysfunction – overview from a cardiovascular                     perspective

Baumann, Frederic; Hehli, D.; Makaloski, Vladimir; Schumacher, Martin; Schönhofen, Heinz; Diehm, Nicolas

doi:10.1024/0301-1526/a000627

Cited by 18 publications

(13 citation statements)

References 43 publications

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“…Therefore, it promotes the release of cytokines, chemokines and dilating hormones 31,34,35 , which facilitates the transfer and migration of leukocytes to the lesion site 36–38 . Erectile dysfunction (ED) and cardiovascular diseases share the same risk factors 39 . As an example, the sustained presence of low-grade inflammatory mediators in patients with ED and coronary artery diseases is well documented 40 .…”

Section: Discussionmentioning

confidence: 99%

The inflammasome NLRP3 plays a dual role on mouse corpora cavernosa relaxation

Fais

Rodrigues

Pereira

et al. 2019

Sci Rep

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NLRP3 plays a role in vascular diseases. Corpora cavernosa (CC) is an extension of the vasculature. We hypothesize that NLRP3 plays a deleterious role in CC relaxation. Male C57BL/6 (WT) and NLRP3 deficient (NLRP3−/−) mice were used. Intracavernosal pressure (ICP/MAP) measurement was performed. Functional responses were obtained from CC strips of WT and NLRP3−/− mice before and after MCC950 (NLRP3 inhibitor) or LPS + ATP (NLRP3 stimulation). NLRP3, caspase-1, IL-1β, eNOS, nNOS, guanylyl cyclase-β1 (GCβ1) and PKG1 protein expressions were determined. ICP/MAP and sodium nitroprusside (SNP)-induced relaxation in CC were decreased in NLRP3−/− mice. Caspase-1, IL-1β and eNOS activity were increased, but PKG1 was reduced in CC of NLRP3−/−. MCC950 decreased non-adrenergic non-cholinergic (NANC), acetylcholine (ACh), and SNP-induced relaxation in WT mice. MCC950 did not alter NLRP3, caspase-1 and IL-1β, but reduced GCβ1 expression. Although LPS + ATP decreased ACh- and SNP-, it increased NANC-induced relaxation in CC from WT, but not from NLRP3−/− mice. LPS + ATP increased NLRP3, caspase-1 and interleukin-1β (IL-1β). Conversely, it reduced eNOS activity and GCβ1 expression. NLRP3 plays a dual role in CC relaxation, with its inhibition leading to impairment of nitric oxide-mediated relaxation, while its activation by LPS + ATP causes decreased CC sensitivity to NO and endothelium-dependent relaxation.

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Section: Discussionmentioning

confidence: 99%

The inflammasome NLRP3 plays a dual role on mouse corpora cavernosa relaxation

Fais

Rodrigues

Pereira

et al. 2019

Sci Rep

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“…Moreover, HCY is also identified to be a useful marker for CVD 26 27. Meanwhile, ED could be a potentially predictive factor for cardiovascular and other chronic diseases 28. Based on the relevance, it was assumed that HCY might be a risk factor for ED 8 9…”

Section: Discussionmentioning

confidence: 99%

Association between homocysteine, vitamin B_₁₂, folic acid and erectile dysfunction: a cross-sectional study in China

Chen

et al. 2019

BMJ Open

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ObjectivesErectile dysfunction (ED) affects up to 53.4% of men aged 30–80 years. In this study, we aimed to examine the association between homocysteine (HCY), vitamin B12 (B12), folic acid (FA) and ED.DesignCross-sectional study.SettingGuangxi, China.ParticipantsA total of 1381 participants who completed questionnaires were included, between September 2009 and December 2009.MeasuresED was evaluated by the International Index of Erectile Function scores. Also, the values of HCY, B12 and FA were acquired. Then, regression and between-group analyses were performed.ResultsNo association between FA and ED was found. Significant correlations between HCY and ED were found—the relationships between these two parameters were most notable in men aged over 60 years and in men living alone (bachelors or bachelorhood). B12 levels were higher in men with ED (718.53±234.37 pg/mL vs 688.74±229.68, p=0.015). Using multinomial logistic regression analyses, B12 levels were related to mild ED (multivariate adjusted analysis: OR 1.620, 95% CI 1.141 to 2.300, p=0.007), especially among men aged 40–49 years (OR 2.907, 95% CI 1.402 to 6.026, p=0.004).ConclusionsWe report, for the first time, a relationship between B12 levels and ED. We also found specific cohorts of men for whom the relationship between HCY levels and ED is most prominent. Further studies are required to elucidate the mechanisms underlying these relationships—these may ultimately result in new therapies for ED.

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“…4 Arterial insufficiency is the leading cause of ED and may result from obstructions of the common and internal iliac arteries as well as the pudendal and penile arteries. 5 It was recently shown that the pudendal artery is the single most frequent arterial segment to be affected by atherosclerotic obstructions in patients with ED of arterial origin. 6 In that study, the average pudendal arterial diameter was very comparable to the average coronary artery diameter.…”

Section: Introductionmentioning

confidence: 99%

“…In patients with ED attributed to arterial disease, endovascular therapy constitutes promising results to restore blood flow and improve clinical outcomes. 5,7,8 However, the ideal antirestenotic regimen within this challenging arterial segment remains to be determined. 7 Given that ED with arterial obstructions of oftentimes small-caliber erection-related arteries may be present even in comparatively young patients, a "leave nothing behind strategy" with drug-coated balloon (DCB) angioplasty may be a favorable treatment option.…”

Section: Introductionmentioning

confidence: 99%

Early Recoil After Balloon Angioplasty of Erection-Related Arteries in Patients With Arteriogenic Erectile Dysfunction

Diehm¹,

Do²,

Keo³

et al. 2018

J Endovasc Ther

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PURPOSE To evaluate the incidence of elastic recoil in patients presenting with erectile dysfunction (ED) undergoing endovascular revascularization of the pudendal or penile arteries. METHODS A consecutive series of 21 ED patients (mean age 58.3±9.3 years) undergoing minimally invasive revascularization of 31 arteries was analyzed. ED lesions included the pudendal arteries (n=27) and the penile artery (n=4). Mean lesion length was 20.6±13.9 mm. Minimal lumen diameter (MLD) measurements were assessed at baseline, immediately after balloon angioplasty, and 10 minutes thereafter. Early recoil was defined as an MLD reduction >10%. Elastic recoil with >10% lumen compromise was treated with drug-coated balloons, while severe elastic recoil (>30%) required drug-eluting stents (DES). The International Index of Erectile Function (IIEF-15) score was obtained prior to and 3 months after the procedure to obtain information on functional outcomes subsequent to angioplasty. RESULTS Mean MLD at baseline was 0.9±0.6 mm, which improved to 2.0±0.9 mm immediately after balloon dilation. At 10 minutes after dilation, the MLD was 1.7±1.0 mm. Elastic recoil was observed in all 31 lesions and resulted in a mean lumen compromise of 21.2%. Severe (>30%) recoil was observed in 14 arteries, which underwent DES therapy. The IIEF-15 score improved from 31.3±11.2 at baseline to 49.8±16.8 (p<0.001) at the 3-month follow-up. CONCLUSION Endovascular revascularization constitutes a safe and feasible treatment modality to restore erectile function in patients with arteriogenic ED and ineffective conservative management. Early elastic recoil is very frequent subsequent to balloon dilation of small-caliber erection-related arteries. Thus, mechanical scaffolding with DES is required in a high subset of ED patients to provide favorable early angiographic and clinical results.

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Erectile dysfunction – overview from a cardiovascular perspective

Cited by 18 publications

References 43 publications

The inflammasome NLRP3 plays a dual role on mouse corpora cavernosa relaxation

The inflammasome NLRP3 plays a dual role on mouse corpora cavernosa relaxation

Association between homocysteine, vitamin B_₁₂, folic acid and erectile dysfunction: a cross-sectional study in China

Early Recoil After Balloon Angioplasty of Erection-Related Arteries in Patients With Arteriogenic Erectile Dysfunction

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Erectile dysfunction – overview from a cardiovascular perspective

Cited by 18 publications

References 43 publications

The inflammasome NLRP3 plays a dual role on mouse corpora cavernosa relaxation

The inflammasome NLRP3 plays a dual role on mouse corpora cavernosa relaxation

Association between homocysteine, vitamin B12, folic acid and erectile dysfunction: a cross-sectional study in China

Early Recoil After Balloon Angioplasty of Erection-Related Arteries in Patients With Arteriogenic Erectile Dysfunction

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Association between homocysteine, vitamin B_₁₂, folic acid and erectile dysfunction: a cross-sectional study in China