Erectile Dysfunction in a Murine Model of Sleep Apnea

Soukhova-O'Hare, Galia K.; Shah, Zahoor A.; Lei, Zhenmin; Nozdrachev, A. D.; Rao, Chinthalapally V.; Gozal, David

doi:10.1164/rccm.200801-190oc

Cited by 71 publications

(47 citation statements)

References 60 publications

(63 reference statements)

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“…A recent review by Hoyos and colleagues in this journal has summarized the available data on erectile dysfunction in the OSA patient population, and proposed that endothelial dysfunction, an early component of cardiovascular disease, may underlie the pathophysiologic link between OSA and erectile dysfunction [183]. Indeed, in a study from our laboratory in a murine model, we demonstrated that the reduced bioavailability of NO accounted for substantial components of the erectile dysfunciton reported in OSA [184].…”

Section: Erectile Dysfunctionmentioning

confidence: 70%

Hemoglobinopathies and sleep – The road less traveled

Gileles‐Hillel

Kheirandish‐Gozal

Gozal

2015

Sleep Medicine Reviews

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Section: Erectile Dysfunctionmentioning

confidence: 70%

Hemoglobinopathies and sleep – The road less traveled

Gileles‐Hillel

Kheirandish‐Gozal

Gozal

2015

Sleep Medicine Reviews

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“…In line with this, recent work using an animal model to determine the role of sleep apnea for ED, showed that sexual activity and spontaneous erections were reduced by chronic intermittent hypoxemia. At the same time, endothelial NO synthase expression was decreased, while testosterone levels remained unchanged [32]. Conversely, patients with altered bulbocavernosus reflex latency and signs of neuropathy showed higher AHI and spent more time at SaO 2 < 90%, suggesting a link between hypoxia and nerval dysfunction [33].…”

Section: Discussionmentioning

confidence: 97%

Sleep Apnea is an Independent Correlate of Erectile and Sexual Dysfunction

Budweiser

Enderlein

Jörres

et al. 2009

The Journal of Sexual Medicine

124

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Introduction Obstructive sleep apnea (OSA) has been linked with erectile dysfunction (ED), but it is unknown whether this association is maintained in the presence of other risk factors for ED. Aim The aim of this study was to evaluate the relationship between ED/sexual dysfunction and polysomnographic measures of sleep apnea in patients with known risk factors for ED. Methods Prospective cross-sectional analysis of 401 male patients undergoing in-lab polysomnography for suspected OSA. Erectile (EF) and sexual function were assessed by the 15-item International Index of Erectile Function (IIEF-15) questionnaire. Main Outcome Measures Severity of OSA via apnea–hypopnea index (AHI) and mean/lowest nocturnal oxygen saturation (SaO2). The IIEF-15 including the sexual domains: EF, intercourse satisfaction, orgasmic function, sexual desire, and overall satisfaction. Results OSA (AHI > 5/h) was diagnosed in 92% of patients. ED (EF subdomain ≤ 25) was present in 69% of patients with, and 34% of patients without OSA (P < 0.001). Multivariate stepwise regression analyses including known risk factors for ED, such as age, obesity, coronary heart disease, peripheral occlusive disease, hypertension, diabetes, prostate surgery, and β-blocker treatment, and measures of sleep apnea identified mean nocturnal SaO2 as independently associated with ED (P = 0.002; mean [95% CI] normalized slope 0.126 [0.047; 0.205]). Age (P < 0.001), peripheral occlusive disease (P = 0.001), prostate surgery (P = 0.018), and hypertension (P = 0.021) were confirmed as risk factors for ED, but did not abolish the sleep apnea-associated risk. Similar results were obtained for sexual dysfunction. Logistic regression analysis using the diagnosis of ED (EF subdomain ≤ 25) as binary dependent variable confirmed that mean nocturnal SaO2 (P = 0.012), as well as age (P < 0.001) were independently associated with ED. Conclusions ED and overall sexual dysfunction were highly prevalent in patients with suspected OSA. Irrespective of known risk factors, mean nocturnal SaO2 was an additional, independent correlate of these dysfunctions, suggesting that OSA-related intermittent nocturnal hypoxemia specifically contributes to their development.

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“…Reports about alterations in psychic, neural, hormonal, and/or vascular systems lead to the assumption of a multifactorial genesis [2,16,17]. Most likely, one or more of these parameters will be the key to the pathophysiology of OSA-induced OAB.…”

Section: Obstructive Sleep Apnea Syndromementioning

confidence: 99%

The relationship between sleep apnea and overactive bladder

Kemmer

2009

Curr Urol Rep

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Approximately 4% to 5% of middle-aged men are affected by obstructive sleep apnea (OSA) syndrome, which is known to cause urologic disorders, cardiovascular diseases, and an increased risk of stroke. The correlation between OSA, erectile dysfunction, and nocturia is well known; a recent study demonstrated the association between overactive bladder and urgency incontinence. This article discusses the current literature and therapeutic options, as well as our own experiences and consequences for affected patients.

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Erectile Dysfunction in a Murine Model of Sleep Apnea

Cited by 71 publications

References 60 publications

Hemoglobinopathies and sleep – The road less traveled

Hemoglobinopathies and sleep – The road less traveled

Sleep Apnea is an Independent Correlate of Erectile and Sexual Dysfunction

The relationship between sleep apnea and overactive bladder

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