Erectile Dysfunction As a Generalized Vascular Dysfunction

Uslu, Nevzat; Görgülü, Şevket; Alper, Ahmet Taha; Eren, Mehmet; Nurkalem, Zekeriya; Yildirim, Aydın; Özer, Orhan

doi:10.1016/j.echo.2005.09.017

Cited by 30 publications

(32 citation statements)

References 28 publications

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“…This finding is not surprising because diabetes is an independent predictor of ED in several studies [5,6,9,19,20]. In the present study, there was a significant association between pathological ED and heart disease, which is in agreement with previous studies [21][22][23]. On the other hand, ED has been considered a significant risk factor for developing cardiovascular disease [24][25][26].…”

Section: Discussionsupporting

confidence: 92%

Erectile Dysfunction among Yemenis: Does Chewing Khat Play a Role?

Nassar¹,

Aklan²

2014

EAJM

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Objective: Khat, a type of plant that grows in Yemen and some African countries like Somalia, Ethiopia and Kenya, is considered to be addictive and contains some stimulating substances that may affect different body organs. This study was conducted to identify the causes of erectile dysfunction (ED) and to investigate the effect of chewing Khat on this disease in Yemenis. Materials and Methods:A total of 236 patients who were treated at University of Science and Technology Hospital and complained of ED were examined with penile Doppler ultrasonography (US). Biodata and health data were collected from the patients' records and via mobile interviews. Results:The causes of ED were psychological causes (72%), venous leakage (19%) and arterial disease (9%). Psychological ED was most common in 15-29-year-olds, while pathological ED increased with increasing age (p=0.041). Heart diseases and diabetes showed a significant association with pathological ED (p<0.05). Although 81% of the ED patients in this study chewed Khat, there was no significant association between chewing Khat and either pathological or psychological ED (p>0.05).Conclusion: Psychological problems are the main causes of ED among Yemenis especially in the younger age group. It is too early to exclude Khat as a factor contributing to this health problem, and this topic warrants further case-control studies with a larger sample size. Sonuç: Psikolojik ED sorunları, özellikle genç yaş grubundaki Yemenliler arasında yaygındır. Bu sağlık sorunu katkı sağlayan bir faktör olarak Khat'ı hariç tutmak için henüz çok erken olduğunu ve daha büyük bir örneklem büyüklüğü ile bu konuyu başka vaka-kontrol çalışmala-rı ile desteklemek gerektiğini düşünmekteyiz.

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Section: Discussionsupporting

confidence: 92%

Erectile Dysfunction among Yemenis: Does Chewing Khat Play a Role?

Nassar¹,

Aklan²

2014

EAJM

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“…[1][2][3] It has been proven in some studies that endothelial function is impaired in patients with ED. [16][17][18] Uslu et al 16 determined a significant reduction in flow-mediated dilatation of brachial artery using Doppler ultrasonography in patients with ED in whom coronary artery disease was excluded and concluded that ED was a component of generalized vascular dysfunction. Erectile function is gradually impaired with age and the incidence of ED increases with accompanying chronic diseases like diabetes mellitus, hypertension and coronary artery disease.…”

Section: Discussionmentioning

confidence: 99%

“…Increased TIMI frame counts were found to be associated with impaired endothelial function. [12][13][14][15][16][17][18][19][20][21][22][23][24] Thus, the underlying mechanism of increased incidence of erectile dysfunction in slow flow patients might be the endothelial dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…All participants completed the IIEF questionnaire. According to questions 1-5 and 15 (six questions that form the so-called 'erectile function domain' 14 ) of the questionnaire, ED severity was classified into five categories as severe (1-10), moderate (11)(12)(13)(14)(15)(16), mild to moderate (17-21), mild (22)(23)(24)(25) and no ED (26)(27)(28)(29)(30) …”

Section: Sexual Function: International Index Of Erectile Functionmentioning

confidence: 99%

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Erectile dysfunction and coronary slow flow: distinct presentations of endothelial disease

et al. 2007

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The aim of the present study was to investigate degree of erectile dysfunction (ED) in males with slow coronary flow (SCF). Endothelial dysfunction was proposed to be the underlying mechanism in both diseases. A total of 29 male patients with slow coronary flow (mean age 4577 years) and 23 male patients with normal coronary arteries (mean age 48712 years) were included in the study. The severity of ED was determined according to the International Index of Erectile Function (IIEF) questionnaire. Mean IIEF scores in patients with SCF and control group were determined as 20.9777.26 and 25.2675.17, P ¼ 0.016. ED was detected in 45% (n ¼ 13) of SCF patients and 35% (n ¼ 8) of the control group (P ¼ 0.035). There was a negative correlation between the mean TIMI frame count and IIEF score between patients with SCF and controls (r ¼ À0.31, P ¼ 0.029). These data suggest that ED is observed more frequently in patients with SCF phenomenon compared to patients with otherwise normal coronary angiograms.

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“…[1][2][3] Many factors are recognized as being the cause of impotence, including psychotic, neurogenic, hormonal and vascular causes. Among these factors, vascular factors are the most common.…”

Section: Introductionmentioning

confidence: 99%

Comparison of one-side and bilateral intracavernosal papaverine injection on a Doppler study of the penis

2009

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Intracavernosal injection of a vasodilating agent, followed by color Doppler ultrasonography of the penis, is used to diagnose vascular impotence. The vasodilating agent is usually injected into one of the corpora cavernosa and the peak systolic velocity (PSV) of the cavernosal arteries is measured on both sides, presuming that the connection between the two cavernosal bodies will distribute the drug uniformly on both sides and will consequently affect the cavernosal arteries and sinusoids equally. According to our experience, the PSV of the injection side is higher than that of the contralateral side. This difference could affect the results of the evaluation. In this study, our objective was to compare the results of both-side injections with those of one-side injection. A total number of 60 patients with a normal Doppler study of the penis were enrolled in the study and were randomly divided into three groups. In the first and second group, 60 mg papaverine was injected into the right and left corpus cavernosa each. In the third group, half of the dose was injected into each side. The mean maximum PSV was measured and compared in each group. The mean maximum PSV in the group with the right-side injection was 47.7±10.8 and 40.3±9.2 on the right and left side, respectively. The mean maximum PSV in the group with the left side injection was 44.4 ± 7.1 and 51.4 ± 7.1 on the right and the left side, respectively. The mean maximum PSV in the group with bilateral injection was 47±9.9 on the right side and 46.7±10.7 on the left side. In the first two groups, there was significant difference between the mean maximum PSV of the right and left cavernosal arteries, but in the third group, there was no significant difference between the mean maximum PSV of both side cavernosal arteries. Injecting papaverine in only one corpus cavernosum, despite a perfect postinjection manipulation of the penis, will affect the sinusoids and cavernosal artery at the same side of the injection more than the contralateral side. This results in a higher increase in the blood flow and PSV on that side and results in an artifactual difference between the velocity of the right and left side, which could ultimately exaggerate or mask the actual difference between the two sides. Dividing the total dose of the vasodilating agent and injecting half of the dose into each corpus cavernosum separately prevents artifactual difference between blood flow and velocity on the right and left side.

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Erectile Dysfunction As a Generalized Vascular Dysfunction

Cited by 30 publications

References 28 publications

Erectile Dysfunction among Yemenis: Does Chewing Khat Play a Role?

Erectile Dysfunction among Yemenis: Does Chewing Khat Play a Role?

Erectile dysfunction and coronary slow flow: distinct presentations of endothelial disease

Comparison of one-side and bilateral intracavernosal papaverine injection on a Doppler study of the penis

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