Erectile Dysfunction and Treatment: An Analysis of Associated Chronic Health Conditions

Wright, Lindsey; Moghalu, Odinachi; Das, Rupam; Horns, Joshua J.; Campbell, Alexander J. A.; Hotaling, James M.; Pastuszak, Alexander W.

doi:10.1016/j.urology.2021.08.009

Cited by 15 publications

(7 citation statements)

References 19 publications

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“…These unique advantages are particularly useful for longitudinal studies and have been leveraged to assess surgical subspecialty outcomes in otolaryngology, neurosurgery, and urology. [9][10][11][12] ii. Outcomes Using International Classi cation of Diseases (ICD) 9 and 10 procedure codes (Supplement Table 1) we identi ed men who had a diagnosis of COVID-19 between January 2020 and January 2021 who subsequently were diagnosed with erectile dysfunction for the rst time.…”

Section: Methods I Data Sourcementioning

confidence: 99%

(526) Association of Prior COVID-19 Infection With Newly Diagnosed Erectile Dysfunction: Evaluation of 42,406 COVID-19 Recovered Men

Hebert

Matta

Horns

et al. 2023

The Journal of Sexual Medicine

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Introduction The SARS-CoV-2 virus and associated COVID-19 infection is known to cause endothelial cell dysfunction. This has led some to hypothesize that COVID-19 infection may increase the risk of erectile dysfunction. Initial studies evaluating this association have been limited to small, single institution studies or have utilized electronic medical record databases that lack universal follow-up given they only capture follow-up care at a small proportion of health care facilities. Objective To assess if COVID-19 infection recovery is associated with increased rates of newly diagnosed erectile dysfunction (ED) using an insurance claims database. Methods Using IBM MarketScan, a commercial claims database, men with prior COVID-19 infection between January 2020 and January 2021 were identified using ICD-10 diagnosis codes. Using this cohort along with an age-matched cohort of men without prior COVID-19 infection, we assessed the incidence of newly diagnosed erectile dysfunction (ED). Men with ED secondary to prostatectomy or radiation were excluded. Covariates were assessed using a multivariable model to determine association of prior COIVD-19 infection with newly diagnosed ED. Results 42,406 men experienced a COVID-19 infection between January 2020 and January 2021 of which 610 (1.44%) developed new onset ED within 6.5 months follow up. On multivariable analysis while controlling for diabetes, cardiovascular disease, smoking, obesity, hypogonadism, thromboembolism, and GU malignancy, prior COVID-19 infection was associated with increased risk of new onset ED (HR 1.27; 95% CI 1.1-1.5; P=0.001). COVID-19 infection carried a similar association with new onset ED as did diabetes and BMI 25-30, HR 1.3 and 1.29, respectively. Conclusions Prior to the widespread implementation of the COVID-19 vaccine, the incidence of newly diagnosed ED is higher in men with prior COVID-19 infection compared to age-matched controls. Prior COVID-19 infection was associated with a 27% increased likelihood of developing new-onset ED when compared to those without prior infection. Additional longitudinal studies are needed to evaluate the risk of erectile dysfunction after following asymptomatic infection and in the setting prior vaccination. Disclosure Any of the authors act as a consultant, employee or shareholder of an industry for: Cooper Medical, Boston Scientific, Acerus, Coloplast, Endo, Turtle Health, Maximus, FirmTech, StreamDx, Inherent Bioscience.

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Section: Methods I Data Sourcementioning

confidence: 99%

(526) Association of Prior COVID-19 Infection With Newly Diagnosed Erectile Dysfunction: Evaluation of 42,406 COVID-19 Recovered Men

Hebert

Matta

Horns

et al. 2023

The Journal of Sexual Medicine

View full text Add to dashboard Cite

show abstract

“…Its ability to evaluate outpatient surgeries and associated complications regardless of where the patient seeks followup care has been leveraged to assess outpatient surgical outcomes in otolaryngology, neurosurgery, and urology. 10–12 This study received Institutional Review Board approval (IRB no. 00123727).…”

Section: Methodsmentioning

confidence: 99%

Risk of Postoperative Thromboembolism in Men Undergoing Urological Prosthetic Surgery: An Assessment of 21,413 Men

et al. 2022

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Purpose:We assessed venous thromboembolism (VTE) and associated risk factors following artificial urinary sphincter (AUS) and inflatable penile prosthesis (IPP) surgery.Materials and Methods:Using IBM® MarketScan, a commercial claims database, patients undergoing AUS and IPP surgery were identified using CPT® and ICD (International Classification of Diseases)-10 procedure codes between 2008 and 2017. ICD-9 and -10 codes were used to identify health care visits associated with lower extremity deep vein thrombosis (DVT) and pulmonary embolism (PE) within 90 days of surgery. Covariates were assessed using a multivariable model to determine association with outcome of DVT and/or PE.Results:A total of 21,413 men underwent AUS (4,870) or IPP (16,543) surgery between 2008 and 2017 with a median age of 62 years and 68 years, respectively. DVT and PE events following AUS and IPP surgery occurred in 1.54% and 1.04%, respectively. A history of varicose veins (HR 2.76; 95% CI 1.11–6.79), prior history of DVT (HR 13.65; 95% CI 7.4–25.19), or PE (HR 7.65; 95% CI 4.01–14.6) in those undergoing AUS surgery was highly associated with development of postoperative VTE. Likewise, prior history of DVT (HR 12.6; 95% CI 7.99–19.93) and PE (HR 8.9; 95% CI 5.6–14.13) was strongly associated with a VTE event following IPP surgery.Conclusions:In a large cohort of men undergoing AUS and IPP surgery, 1.54% and 1.04% of men experienced a VTE event within 90 days of surgery, respectively. Prior history of varicose veins, DVT, and PE was associated with an increased likelihood of developing a postoperative DVT or PE.

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“…Thus far, ED has become an increasingly prevalent problem worldwide and affects quality of life (Wang, Deng, et al, 2021). ED affects as many as one-third of the total global male population, and its prevalence increases with age (Lue, 2000;Wright et al, 2021). The Massachusetts male ageing study (MMAS) and the European Male Ageing Study (EMAS) also presented similar statistics: the combined prevalence of minimal, moderate and complete impotence was 52%.…”

Section: Introductionmentioning

confidence: 91%

Effect of liver cirrhosis on erectile function in rats: A study combining bioinformatics analysis and experimental research

et al. 2021

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To explore the mechanism through which liver cirrhosis (LC) causes erectile dysfunction (ED). Bioinformatic analysis was used to predict the potential signalling pathways in LC-induced ED, and N-nitrosodiethylamine was used to establish a rat model of LC. H&E staining, Western blotting and RT-qPCR were used to detect pathological tissue damage and changes in mRNA and protein expression levels. In addition, the expression levels of sex hormones such as estradiol (E2), prolactin (PRL) and testosterone (T)were measured. The hypoxia-inducible factor (HIF) pathway was an important pathway in our bioinformatics prediction. Pathological damages were detected in the liver and penile tissues of the model rats. Compared with the normal group's serum hormone levels, E2 and PRL were increased in LC rats, while T was decreased (p < 0.01).The mRNA and protein expression results from penis tissues showed that endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS) were both downregulated, and HIF-1α was upregulated in the model group compared to the normal group (p < 0.01). These data suggest that LC hinders erectile function and causes histopathological changes in the penis by affecting the expression of HIF-1α, eNOS, iNOS, E2, PRL and T.

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Erectile Dysfunction and Treatment: An Analysis of Associated Chronic Health Conditions

Cited by 15 publications

References 19 publications

(526) Association of Prior COVID-19 Infection With Newly Diagnosed Erectile Dysfunction: Evaluation of 42,406 COVID-19 Recovered Men

(526) Association of Prior COVID-19 Infection With Newly Diagnosed Erectile Dysfunction: Evaluation of 42,406 COVID-19 Recovered Men

Risk of Postoperative Thromboembolism in Men Undergoing Urological Prosthetic Surgery: An Assessment of 21,413 Men

Effect of liver cirrhosis on erectile function in rats: A study combining bioinformatics analysis and experimental research

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